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- W2801238424 abstract "Objective: To study the point prevalence of single nucleotide polymorphisms (SNPs) in CYP2C19*2 allele in healthy individuals and patients on clopidogrel for secondary prophylaxis, identified treatment failure among them. Background: CYP2C19 is essential for clopidogrel activation. Genetic polymorphisms in CYP2C19 have significant role in the metabolism of clopidogrel. SNPs, CYP2C19*1 are associated with normal metabolism whereas CYP2C19*2 (most prevalent in Asian ethnicity) and CYP2C19*3 are associated with reduced metabolism and treatment failure. Design/Methods: The SNPs associated with CYP2C19*2 were studied among 72 persons by TaqMan genotyping (qPCR) after genomic DNA isolation from peripheral blood. Results: Among 72 individuals in the study, 50(69.4%) were on clopidogrel and 22(30.6%) were not on clopidogrel. Among the individuals on clopidogrel therapy 20 individuals had recurrent atherothrombotic events and 30 had no recurrence. 54(75%) individuals were males and 18(25%) were females. 42 individuals(58.3%) were found to have heterozygous variant (AG for GG) and predicted to be intermediate metabolizers. 15 individuals(20.8%) were homozygous (AA for GG) and predicted to be poor metabolizers. 15 individuals(20.8%) were found to be normal metabolizers (GG). Among 20 individuals who had recurrence on clopidogrel, 4(4/20) (20%) were normal metabolizers. 11(55%) were intermediate metabolizers and 5(25%) were poor metabolizers. Among 30 individuals on clopidogrel without recurrence, 3(3/30)10% were normal metabolizers. 20(66.7%) were intermediate metabolizers. 7(23.3%) were poor metabolizers. Among 22 individuals who were not on clopidogrel, 8(8/22)36.4% were normal metabolizers, 11(50%) were intermediate metabolizers, 3(13.6%) were poor metabolizers. Overall, 52(72.2%) were intermediate metabolizers and 15(20.8%) were poor metabolizers and 15(20.8%) were normal metabolizers. Conclusions: There is high prevalence of CYP2C19*2 allele in Indian population resulting in clopidogrel resistance/treatment failure. Disclosure: Dr. Shivaraman M M has nothing to disclose. Dr. Nazarene has nothing to disclose. Dr. Ranganathan has nothing to disclose. Dr. Ravi Chandar has nothing to disclose. Dr. S has nothing to disclose. Dr. Shankar has nothing to disclose." @default.
- W2801238424 created "2018-05-17" @default.
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- W2801238424 date "2017-04-18" @default.
- W2801238424 modified "2023-09-26" @default.
- W2801238424 title "THE SINGLE NUCLEOTIDE POLYMORPHISMS (SNPs) IN CYTOCHROME P450 2C19 AND CLOPIDOGREL RESISTANCE IN INDIAN POPULATION (P1.256)" @default.
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