FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801246535> ?p ?o ?g. }

• W2801246535 endingPage "2111" @default.
• W2801246535 startingPage "2098" @default.
• W2801246535 abstract "Modern ischaemic stroke management involves intravenous thrombolysis followed by mechanical thrombectomy, which allows markedly higher rates of recanalization and penumbral salvage than thrombolysis alone. However, <50% of treated patients eventually enjoy independent life. It is therefore important to identify complementary therapeutic targets. In rodent models, the salvaged penumbra is consistently affected by selective neuronal loss, which may hinder recovery by interfering with plastic processes, as well as by microglial activation, which may exacerbate neuronal death. However, whether the salvaged penumbra in man is similarly affected is still unclear. Here we determined whether these two processes affect the non-infarcted penumbra in man and, if so, whether they are inter-related. We prospectively recruited patients with (i) acute middle-cerebral artery stroke; (ii) penumbra present on CT perfusion obtained <4.5 h of stroke onset; and (iii) early neurological recovery as a marker of penumbral salvage. PET with 11C-flumazenil and 11C-PK11195, as well as MRI to map the final infarct, were obtained at predefined follow-up times. The presence of selective neuronal loss and microglial activation was determined voxel-wise within the MRI normal-appearing ipsilateral non-infarcted zone and surviving penumbra masks, and their inter-relationship was assessed both across and within patients. Dilated infarct contours were consistently excluded to control for partial volume effects. Across the 16 recruited patients, there was reduced 11C-flumazenil and increased 11C-PK11195 binding in the whole ipsilateral non-infarcted zone (P = 0.04 and 0.02, respectively). Within the non-infarcted penumbra, 11C-flumazenil was also reduced (P = 0.001), but without clear increase in 11C-PK11195 (P = 0.18). There was no significant correlation between 11C-flumazenil and 11C-PK11195 in either compartment. This mechanistic study provides direct evidence for the presence of both neuronal loss and microglial activation in the ipsilateral non-infarcted zone. Further, we demonstrate the presence of neuronal loss affecting the surviving penumbra, with no or only mild microglial activation, and no significant relationship between these two processes. Thus, microglial activation may not contribute to penumbral neuronal loss in man, and its presence in the ipsilateral hemisphere may merely reflect secondary remote degeneration. Selective neuronal loss in the surviving penumbra may represent a novel therapeutic target as an adjunct to penumbral salvage to further improve functional outcome. However, microglial activation may not stand as the primary therapeutic approach. Protecting the penumbra by acutely improving perfusion and oxygenation in conjunction with thrombectomy for example, may be a better approach. 11C-flumazenil PET would be useful to monitor the effects of such therapies." @default.
• W2801246535 created "2018-05-17" @default.
• W2801246535 creator A5003794882 @default.
• W2801246535 creator A5009292765 @default.
• W2801246535 creator A5012602068 @default.
• W2801246535 creator A5012826856 @default.
• W2801246535 creator A5060098812 @default.
• W2801246535 creator A5064571229 @default.
• W2801246535 creator A5069550548 @default.
• W2801246535 creator A5075493660 @default.
• W2801246535 date "2018-05-09" @default.
• W2801246535 modified "2023-10-14" @default.
• W2801246535 title "Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man" @default.
• W2801246535 cites W1023952082 @default.
• W2801246535 cites W1543220690 @default.
• W2801246535 cites W1579380576 @default.
• W2801246535 cites W1965509912 @default.
• W2801246535 cites W1965593262 @default.
• W2801246535 cites W1970031775 @default.
• W2801246535 cites W1972534236 @default.
• W2801246535 cites W1978157075 @default.
• W2801246535 cites W1983246821 @default.
• W2801246535 cites W1988591730 @default.
• W2801246535 cites W1989754340 @default.
• W2801246535 cites W1989985571 @default.
• W2801246535 cites W1990064978 @default.
• W2801246535 cites W1996604050 @default.
• W2801246535 cites W2006558385 @default.
• W2801246535 cites W2009757017 @default.
• W2801246535 cites W2010158282 @default.
• W2801246535 cites W2015558251 @default.
• W2801246535 cites W2017195811 @default.
• W2801246535 cites W2017765500 @default.
• W2801246535 cites W2017831328 @default.
• W2801246535 cites W2019172625 @default.
• W2801246535 cites W2019900217 @default.
• W2801246535 cites W2022326834 @default.
• W2801246535 cites W2027595995 @default.
• W2801246535 cites W2029173430 @default.
• W2801246535 cites W2029446823 @default.
• W2801246535 cites W2030547008 @default.
• W2801246535 cites W2032173134 @default.
• W2801246535 cites W2032956460 @default.
• W2801246535 cites W2036827636 @default.
• W2801246535 cites W2038018468 @default.
• W2801246535 cites W2044154741 @default.
• W2801246535 cites W2049434249 @default.
• W2801246535 cites W2051237723 @default.
• W2801246535 cites W2051882908 @default.
• W2801246535 cites W2053759106 @default.
• W2801246535 cites W2060157715 @default.
• W2801246535 cites W2063541896 @default.
• W2801246535 cites W2065423367 @default.
• W2801246535 cites W2067660567 @default.
• W2801246535 cites W2068658474 @default.
• W2801246535 cites W2070998287 @default.
• W2801246535 cites W2074465892 @default.
• W2801246535 cites W2075624792 @default.
• W2801246535 cites W2076245072 @default.
• W2801246535 cites W2080190646 @default.
• W2801246535 cites W2080370764 @default.
• W2801246535 cites W2084034568 @default.
• W2801246535 cites W2089136110 @default.
• W2801246535 cites W2093694387 @default.
• W2801246535 cites W2093763120 @default.
• W2801246535 cites W2095544898 @default.
• W2801246535 cites W2097620703 @default.
• W2801246535 cites W2101516527 @default.
• W2801246535 cites W2102288785 @default.
• W2801246535 cites W2106962867 @default.
• W2801246535 cites W2107831538 @default.
• W2801246535 cites W2109412314 @default.
• W2801246535 cites W2116043572 @default.
• W2801246535 cites W2117273008 @default.
• W2801246535 cites W2117671988 @default.
• W2801246535 cites W2118110686 @default.
• W2801246535 cites W2123894485 @default.
• W2801246535 cites W2132878222 @default.
• W2801246535 cites W2134685106 @default.
• W2801246535 cites W2134729461 @default.
• W2801246535 cites W2138789529 @default.
• W2801246535 cites W2142624163 @default.
• W2801246535 cites W2154075376 @default.
• W2801246535 cites W2158639441 @default.
• W2801246535 cites W2159689462 @default.
• W2801246535 cites W2165568749 @default.
• W2801246535 cites W2167585586 @default.
• W2801246535 cites W2167786770 @default.
• W2801246535 cites W2169731332 @default.
• W2801246535 cites W2180684088 @default.
• W2801246535 cites W2260335648 @default.
• W2801246535 cites W2270360032 @default.
• W2801246535 cites W2277258071 @default.
• W2801246535 cites W2345329114 @default.
• W2801246535 cites W2419532403 @default.
• W2801246535 cites W2462104447 @default.
• W2801246535 cites W2497241389 @default.
• W2801246535 cites W2520620547 @default.

• next