FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801263161> ?p ?o ?g. }

• W2801263161 endingPage "e161" @default.
• W2801263161 startingPage "e147" @default.
• W2801263161 abstract "There is limited information on O6-methylguanine DNA methyltransferase (MGMT) status, extent of surgical resection, and its impact on overall outcomes in patients with glioblastoma (GBM). After institutional review board approval, 233 newly diagnosed patients with GBM with known MGMT status (2009–2015) were included in our analysis. Clinical, imaging, and follow-up data were collected from the database. Overall survival (OS) and progression-free survival (PFS) were the primary and secondary end points, respectively. Of patients, 51.9% were younger than 65 years and 44.2% were noted to have promoter methylation of MGMT. Median residual tumor volume was 1.1 cm3 and extent of complete resection of enhancing tumor on imaging was 96%. Estimated median OS and PFS were 10.9 months and 5.4 months, respectively. MGMT status was an independent predictor of PFS (hazard ratio [HR], 0.52; P = 0.005) but only marginally associated with OS (P = 0.059). In MGMT methylated patients, extent of resection (≥86%) and good performance status (Karnofsky Performance Status ≥70) were independently associated with PFS and OS, respectively (PFS: HR, 0.21; P = 0.015; OS: HR, 0.05; P = 0.002). In MGMT promoter unmethylated patients, extent of resection (≥86%) was independently associated with OS (P = 0.039). Concurrent chemoradiotherapy was associated with OS/PFS irrespective of age and MGMT status. Greater extent of resection of enhancing tumor was associated with improved PFS in MGMT promoter methylated patients, OS regardless of MGMT status. Elderly patients with methylated MGMT promoter were found to have improved PFS whereas younger patients had improved OS with MGMT promoter methylated status." @default.
• W2801263161 created "2018-05-17" @default.
• W2801263161 creator A5018546150 @default.
• W2801263161 creator A5019955137 @default.
• W2801263161 creator A5021893710 @default.
• W2801263161 creator A5029695871 @default.
• W2801263161 creator A5029857725 @default.
• W2801263161 creator A5032295347 @default.
• W2801263161 creator A5035416012 @default.
• W2801263161 creator A5039448543 @default.
• W2801263161 creator A5065263618 @default.
• W2801263161 creator A5070846785 @default.
• W2801263161 date "2018-08-01" @default.
• W2801263161 modified "2023-09-26" @default.
• W2801263161 title "Correlation Between the Residual Tumor Volume, Extent of Tumor Resection, and O6-Methylguanine DNA Methyltransferase Status in Patients with Glioblastoma" @default.
• W2801263161 cites W2000924030 @default.
• W2801263161 cites W2004423127 @default.
• W2801263161 cites W2052491055 @default.
• W2801263161 cites W2059624809 @default.
• W2801263161 cites W2094386848 @default.
• W2801263161 cites W2096287682 @default.
• W2801263161 cites W2098548617 @default.
• W2801263161 cites W2098785952 @default.
• W2801263161 cites W2104633297 @default.
• W2801263161 cites W2105100844 @default.
• W2801263161 cites W2121749405 @default.
• W2801263161 cites W2131981377 @default.
• W2801263161 cites W2141699748 @default.
• W2801263161 cites W2141713919 @default.
• W2801263161 cites W2145376545 @default.
• W2801263161 cites W2154526619 @default.
• W2801263161 cites W2158681922 @default.
• W2801263161 cites W2227625267 @default.
• W2801263161 cites W2328946792 @default.
• W2801263161 cites W2366536035 @default.
• W2801263161 cites W2574800639 @default.
• W2801263161 cites W2590936958 @default.
• W2801263161 cites W2591716768 @default.
• W2801263161 cites W2594077503 @default.
• W2801263161 cites W4245392732 @default.
• W2801263161 doi "https://doi.org/10.1016/j.wneu.2018.04.134" @default.
• W2801263161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29709748" @default.
• W2801263161 hasPublicationYear "2018" @default.
• W2801263161 type Work @default.
• W2801263161 sameAs 2801263161 @default.
• W2801263161 citedByCount "7" @default.
• W2801263161 countsByYear W28012631612019 @default.
• W2801263161 countsByYear W28012631612020 @default.
• W2801263161 countsByYear W28012631612021 @default.
• W2801263161 countsByYear W28012631612022 @default.
• W2801263161 countsByYear W28012631612023 @default.
• W2801263161 crossrefType "journal-article" @default.
• W2801263161 hasAuthorship W2801263161A5018546150 @default.
• W2801263161 hasAuthorship W2801263161A5019955137 @default.
• W2801263161 hasAuthorship W2801263161A5021893710 @default.
• W2801263161 hasAuthorship W2801263161A5029695871 @default.
• W2801263161 hasAuthorship W2801263161A5029857725 @default.
• W2801263161 hasAuthorship W2801263161A5032295347 @default.
• W2801263161 hasAuthorship W2801263161A5035416012 @default.
• W2801263161 hasAuthorship W2801263161A5039448543 @default.
• W2801263161 hasAuthorship W2801263161A5065263618 @default.
• W2801263161 hasAuthorship W2801263161A5070846785 @default.
• W2801263161 hasConcept C126322002 @default.
• W2801263161 hasConcept C143998085 @default.
• W2801263161 hasConcept C207103383 @default.
• W2801263161 hasConcept C2776194525 @default.
• W2801263161 hasConcept C2776694085 @default.
• W2801263161 hasConcept C2776907518 @default.
• W2801263161 hasConcept C2777389519 @default.
• W2801263161 hasConcept C2778424827 @default.
• W2801263161 hasConcept C2779527866 @default.
• W2801263161 hasConcept C2780739268 @default.
• W2801263161 hasConcept C2910123053 @default.
• W2801263161 hasConcept C3019894029 @default.
• W2801263161 hasConcept C33288867 @default.
• W2801263161 hasConcept C44249647 @default.
• W2801263161 hasConcept C502942594 @default.
• W2801263161 hasConcept C54355233 @default.
• W2801263161 hasConcept C552990157 @default.
• W2801263161 hasConcept C71924100 @default.
• W2801263161 hasConcept C86803240 @default.
• W2801263161 hasConcept C91965660 @default.
• W2801263161 hasConceptScore W2801263161C126322002 @default.
• W2801263161 hasConceptScore W2801263161C143998085 @default.
• W2801263161 hasConceptScore W2801263161C207103383 @default.
• W2801263161 hasConceptScore W2801263161C2776194525 @default.
• W2801263161 hasConceptScore W2801263161C2776694085 @default.
• W2801263161 hasConceptScore W2801263161C2776907518 @default.
• W2801263161 hasConceptScore W2801263161C2777389519 @default.
• W2801263161 hasConceptScore W2801263161C2778424827 @default.
• W2801263161 hasConceptScore W2801263161C2779527866 @default.
• W2801263161 hasConceptScore W2801263161C2780739268 @default.
• W2801263161 hasConceptScore W2801263161C2910123053 @default.
• W2801263161 hasConceptScore W2801263161C3019894029 @default.
• W2801263161 hasConceptScore W2801263161C33288867 @default.
• W2801263161 hasConceptScore W2801263161C44249647 @default.
• W2801263161 hasConceptScore W2801263161C502942594 @default.
• W2801263161 hasConceptScore W2801263161C54355233 @default.

• next