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- W2801264549 endingPage "696" @default.
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- W2801264549 abstract "The greatest unmet medical need in Parkinson's disease (PD) is treatments that slow the relentless progression of symptoms. The discovery of genetic variants causing and/or increasing the risk for PD has provided the field with a new arsenal of potential therapies ready to be tested in clinical trials. We highlight 3 of the genetic discoveries (α-synuclein, glucocerebrosidase, and leucine-rich repeat kinase) that have prompted new therapeutic approaches now entering the clinical stages. We are at an exciting juncture in the journey to developing disease-modifying treatments based on knowledge of PD genetics and pathology. This review focuses on therapeutic paradigms that are under clinical development and highlights a wide range of key outstanding questions in PD. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society." @default.
- W2801264549 created "2018-05-17" @default.
- W2801264549 creator A5015630245 @default.
- W2801264549 creator A5039563040 @default.
- W2801264549 creator A5072622786 @default.
- W2801264549 date "2018-04-27" @default.
- W2801264549 modified "2023-10-10" @default.
- W2801264549 title "Targeted Therapies for Parkinson's Disease: From Genetics to the Clinic" @default.
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- W2801264549 doi "https://doi.org/10.1002/mds.27414" @default.
- W2801264549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6282975" @default.
- W2801264549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29704272" @default.
- W2801264549 hasPublicationYear "2018" @default.
- W2801264549 type Work @default.