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• W2801274071 abstract "Immune cell–mediated attack on the liver is a defining feature of autoimmune hepatitis and hepatic allograft rejection. Despite an assortment of diagnostic tools, invasive biopsies remain the only method for identifying immune cells in the liver. We evaluated whether PET imaging with radiotracers that quantify immune activation (¹⁸F-FDG and ¹⁸F-1-(2′-deoxy-2′-fluoro-arabinofuranosyl)cytosine [¹⁸F-FAC]) and hepatocyte biology (¹⁸F-2-deoxy-2-fluoroarabinose [¹⁸F-DFA]) can visualize and quantify liver-infiltrating immune cells and hepatocyte inflammation, respectively, in a preclinical model of autoimmune hepatitis. <b>Methods:</b> Mice treated with concanavalin A (ConA) to induce a model of autoimmune hepatitis or vehicle were imaged with ¹⁸F-FDG, ¹⁸F-FAC, and ¹⁸F-DFA PET. Immunohistochemistry, digital autoradiography, and ex vivo accumulation assays were used to localize areas of altered radiotracer accumulation in the liver. For comparison, mice treated with an adenovirus to induce a viral hepatitis were imaged with ¹⁸F-FDG, ¹⁸F-FAC, and ¹⁸F-DFA PET. ¹⁸F-FAC PET was performed on mice treated with ConA and vehicle or with ConA and dexamethasone. Biopsy samples of patients with autoimmune hepatitis were immunostained for deoxycytidine kinase. <b>Results:</b> Hepatic accumulation of ¹⁸F-FDG and ¹⁸F-FAC was 173% and 61% higher, respectively, and hepatic accumulation of ¹⁸F-DFA was 41% lower, in a mouse model of autoimmune hepatitis than in control mice. Increased hepatic ¹⁸F-FDG accumulation was localized to infiltrating leukocytes and inflamed sinusoidal endothelial cells, increased hepatic ¹⁸F-FAC accumulation was concentrated in infiltrating CD4 and CD8 cells, and decreased hepatic ¹⁸F-DFA accumulation was apparent in hepatocytes throughout the liver. In contrast, viral hepatitis increased hepatic ¹⁸F-FDG accumulation by 109% and decreased hepatic ¹⁸F-DFA accumulation by 20% but had no effect on hepatic ¹⁸F-FAC accumulation (nonsignificant 2% decrease). ¹⁸F-FAC PET provided a noninvasive biomarker of the efficacy of dexamethasone for treating the autoimmune hepatitis model. Infiltrating leukocytes in liver biopsy samples from patients with autoimmune hepatitis express high levels of deoxycytidine kinase, a rate-limiting enzyme in the accumulation of ¹⁸F-FAC. <b>Conclusion:</b> Our data suggest that PET can be used to noninvasively visualize activated leukocytes and inflamed hepatocytes in a mouse model of autoimmune hepatitis." @default.
• W2801274071 created "2018-05-17" @default.
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• W2801274071 date "2018-04-26" @default.
• W2801274071 modified "2023-10-18" @default.
• W2801274071 title "¹⁸F-FAC PET Selectively Images Liver-Infiltrating CD4 and CD8 T Cells in a Mouse Model of Autoimmune Hepatitis" @default.
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• W2801274071 doi "https://doi.org/10.2967/jnumed.118.210328" @default.
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