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- W2801276198 abstract "Abstract Systemic sclerosis ( SS c) is a rare disorder of the connective tissue characterized by fibrosis of the skin, skeletal muscles and visceral organs. Additional manifestations include activation of the immune system and vascular injury. SS c causes disability and death as the result of end‐stage organ failure. Two clinical subsets of the SS c are accepted: limited cutaneous SS c (lc‐ SS c) and diffuse cutaneous SS c (dc‐ SS c). At present, the aetiology and pathogenesis of SS c remain obscure, and consequently, disease outcome is unpredictable. Numerous studies suggest that reactive oxidizing species ( ROS ) play an important role in the pathogenesis of scleroderma. Over the years, several reports have supported this hypothesis for both lc‐ SS c and dc‐ SS c, although the specific role of oxidative stress in the pathogenesis of vascular injury and fibrosis remains to be clarified. The aim of the present review was to report and comment the recent findings regarding the involvement and role of oxidative stress in SS c pathogenesis. Biomarkers proving the link between ROS and the main pathological features of SS c have been summarized." @default.
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- W2801276198 date "2018-04-17" @default.
- W2801276198 modified "2023-10-09" @default.
- W2801276198 title "Oxidative stress in the pathogenesis of systemic scleroderma: An overview" @default.
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- W2801276198 doi "https://doi.org/10.1111/jcmm.13630" @default.
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