Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801285189> ?p ?o ?g. }
- W2801285189 abstract "Abstract Tapping into the metabolic cross-talk between a host and its virus can reveal unique strategies employed during infection. Viral infection is a dynamic process that generates an evolving metabolic landscape. Gaining a continuous view into the infection process is highly challenging and is limited by current metabolomics approaches, which typically measure the average of the entire population at various stages of infection. Here, we took a novel approach to study the metabolic basis of host-virus interactions between the bloom-forming alga Emiliania huxleyi and its specific virus. We combined a classical method in virology, plaque assay, with advanced mass spectrometry imaging (MSI), an approach we termed ‘ in plaque -MSI’. Taking advantage of the spatial characteristics of the plaque, we mapped the metabolic landscape induced during infection in a high spatiotemporal resolution, unfolding the infection process in a continuous manner. Further unsupervised spatially-aware clustering, combined with known lipid biomarkers, revealed a systematic metabolic shift towards lipids containing the odd-chain fatty acid pentadecanoic acid (C15:0) induced during infection. Applying ‘ in plaque -MSI’ might pave the way for the discovery of novel bioactive compounds that mediate the chemical arms race of host-virus interactions in diverse model systems." @default.
- W2801285189 created "2018-05-17" @default.
- W2801285189 creator A5005850438 @default.
- W2801285189 creator A5019651982 @default.
- W2801285189 creator A5026171626 @default.
- W2801285189 creator A5026316454 @default.
- W2801285189 creator A5033719209 @default.
- W2801285189 creator A5040770479 @default.
- W2801285189 creator A5062139071 @default.
- W2801285189 creator A5068822950 @default.
- W2801285189 creator A5069547114 @default.
- W2801285189 creator A5075643061 @default.
- W2801285189 creator A5078275412 @default.
- W2801285189 creator A5091461249 @default.
- W2801285189 date "2018-05-08" @default.
- W2801285189 modified "2023-10-03" @default.
- W2801285189 title "‘<i>In plaque</i>-mass spectrometry imaging’ reveals a major metabolic shift towards odd-chain fatty acid lipids induced by host-virus interactions" @default.
- W2801285189 cites W1133535075 @default.
- W2801285189 cites W1566121095 @default.
- W2801285189 cites W1611854178 @default.
- W2801285189 cites W1620090183 @default.
- W2801285189 cites W1630902802 @default.
- W2801285189 cites W1736186606 @default.
- W2801285189 cites W1797582458 @default.
- W2801285189 cites W1921560948 @default.
- W2801285189 cites W1939931704 @default.
- W2801285189 cites W1964671597 @default.
- W2801285189 cites W1974681473 @default.
- W2801285189 cites W1974683325 @default.
- W2801285189 cites W1979202113 @default.
- W2801285189 cites W1979218070 @default.
- W2801285189 cites W1979365613 @default.
- W2801285189 cites W1980871955 @default.
- W2801285189 cites W1987070132 @default.
- W2801285189 cites W1995168196 @default.
- W2801285189 cites W1996838105 @default.
- W2801285189 cites W1997198731 @default.
- W2801285189 cites W2004620076 @default.
- W2801285189 cites W2007404630 @default.
- W2801285189 cites W2013814361 @default.
- W2801285189 cites W2021096035 @default.
- W2801285189 cites W2023832414 @default.
- W2801285189 cites W2030827705 @default.
- W2801285189 cites W2043077459 @default.
- W2801285189 cites W2043709398 @default.
- W2801285189 cites W2044699485 @default.
- W2801285189 cites W2044775283 @default.
- W2801285189 cites W2049183196 @default.
- W2801285189 cites W2056162021 @default.
- W2801285189 cites W2057652593 @default.
- W2801285189 cites W2059154692 @default.
- W2801285189 cites W2063874036 @default.
- W2801285189 cites W2066873436 @default.
- W2801285189 cites W2068514636 @default.
- W2801285189 cites W2069701412 @default.
- W2801285189 cites W2071137319 @default.
- W2801285189 cites W2073721556 @default.
- W2801285189 cites W2075108782 @default.
- W2801285189 cites W2075247874 @default.
- W2801285189 cites W2083238898 @default.
- W2801285189 cites W2084916970 @default.
- W2801285189 cites W2096769282 @default.
- W2801285189 cites W2117920342 @default.
- W2801285189 cites W2132051679 @default.
- W2801285189 cites W2141193948 @default.
- W2801285189 cites W2144803530 @default.
- W2801285189 cites W2147214095 @default.
- W2801285189 cites W2148130082 @default.
- W2801285189 cites W2149590679 @default.
- W2801285189 cites W2150827955 @default.
- W2801285189 cites W2159672259 @default.
- W2801285189 cites W2163967869 @default.
- W2801285189 cites W2168530080 @default.
- W2801285189 cites W2197186749 @default.
- W2801285189 cites W2260395905 @default.
- W2801285189 cites W2277421940 @default.
- W2801285189 cites W2279854728 @default.
- W2801285189 cites W2293759222 @default.
- W2801285189 cites W2296778984 @default.
- W2801285189 cites W2334419113 @default.
- W2801285189 cites W2346249063 @default.
- W2801285189 cites W2460813857 @default.
- W2801285189 cites W2497367122 @default.
- W2801285189 cites W2571545805 @default.
- W2801285189 cites W2606493877 @default.
- W2801285189 cites W2650022913 @default.
- W2801285189 cites W2745002103 @default.
- W2801285189 cites W2750277627 @default.
- W2801285189 cites W2755255025 @default.
- W2801285189 cites W2755312835 @default.
- W2801285189 cites W2766037655 @default.
- W2801285189 cites W2772374260 @default.
- W2801285189 cites W2775633464 @default.
- W2801285189 cites W2786394271 @default.
- W2801285189 cites W759647746 @default.
- W2801285189 doi "https://doi.org/10.1101/317206" @default.
- W2801285189 hasPublicationYear "2018" @default.
- W2801285189 type Work @default.
- W2801285189 sameAs 2801285189 @default.
- W2801285189 citedByCount "1" @default.