FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801288565> ?p ?o ?g. }

• W2801288565 endingPage "e1007311" @default.
• W2801288565 startingPage "e1007311" @default.
• W2801288565 abstract "Adrenergic α2C receptor (ADRA2C) is an inhibitory modulator of the sympathetic nervous system. Knockout mice for this gene show physiological and behavioural alterations that are associated with the fight-or-flight response. There is evidence of positive selection on the regulation of this gene during chicken domestication. Here, we find that the neuronal expression of ADRA2C is lower in human and chimpanzee than in other primates. On the basis of three-dimensional chromatin structure, we identified a cis-regulatory region whose DNA sequences have been significantly accelerated in human and chimpanzee. Active histone modification marks this region in rhesus macaque but not in human and chimpanzee; instead, repressive marks are enriched in various human brain samples. This region contains two neuron-restrictive silencer factor (NRSF) binding motifs, each of which harbours a polymorphism. Our genotyping and analysis of population genome data indicate that at both polymorphic sites, the derived allele has reached fixation in humans and chimpanzees but not in bonobos, whereas only the ancestral allele is present among macaques. Our CRISPR/Cas9 genome editing and reporter assays show that both derived nucleotides repress ADRA2C, most likely by increasing NRSF binding. In addition, we detected signatures of recent positive selection for lower neuronal ADRA2C expression in humans. Our findings indicate that there has been selective pressure for enhanced sympathetic nervous activity in the evolution of humans and chimpanzees." @default.
• W2801288565 created "2018-05-17" @default.
• W2801288565 creator A5001892334 @default.
• W2801288565 creator A5002416298 @default.
• W2801288565 creator A5004301892 @default.
• W2801288565 creator A5007947168 @default.
• W2801288565 creator A5011542020 @default.
• W2801288565 creator A5046383405 @default.
• W2801288565 creator A5053251909 @default.
• W2801288565 creator A5079759086 @default.
• W2801288565 creator A5080217028 @default.
• W2801288565 creator A5084213906 @default.
• W2801288565 date "2018-04-19" @default.
• W2801288565 modified "2023-10-17" @default.
• W2801288565 title "Selection on the regulation of sympathetic nervous activity in humans and chimpanzees" @default.
• W2801288565 cites W1528722660 @default.
• W2801288565 cites W1964733653 @default.
• W2801288565 cites W1965621126 @default.
• W2801288565 cites W1977294183 @default.
• W2801288565 cites W1983275320 @default.
• W2801288565 cites W2004966039 @default.
• W2801288565 cites W2006838271 @default.
• W2801288565 cites W2017840637 @default.
• W2801288565 cites W2018838463 @default.
• W2801288565 cites W2024439539 @default.
• W2801288565 cites W2025253353 @default.
• W2801288565 cites W2025289680 @default.
• W2801288565 cites W2055543630 @default.
• W2801288565 cites W2060256600 @default.
• W2801288565 cites W2062254307 @default.
• W2801288565 cites W2076154138 @default.
• W2801288565 cites W2078059415 @default.
• W2801288565 cites W2080609613 @default.
• W2801288565 cites W2084620487 @default.
• W2801288565 cites W2085384621 @default.
• W2801288565 cites W2094379190 @default.
• W2801288565 cites W2095718954 @default.
• W2801288565 cites W2095907724 @default.
• W2801288565 cites W2096791516 @default.
• W2801288565 cites W2102951980 @default.
• W2801288565 cites W2103441770 @default.
• W2801288565 cites W2106397195 @default.
• W2801288565 cites W2108120430 @default.
• W2801288565 cites W2109183238 @default.
• W2801288565 cites W2111240301 @default.
• W2801288565 cites W2115264273 @default.
• W2801288565 cites W2117123843 @default.
• W2801288565 cites W2117792884 @default.
• W2801288565 cites W2118761285 @default.
• W2801288565 cites W2119180969 @default.
• W2801288565 cites W2123564569 @default.
• W2801288565 cites W2127608175 @default.
• W2801288565 cites W2127864194 @default.
• W2801288565 cites W2128969076 @default.
• W2801288565 cites W2132150051 @default.
• W2801288565 cites W2134599124 @default.
• W2801288565 cites W2135030836 @default.
• W2801288565 cites W2136557734 @default.
• W2801288565 cites W2140784970 @default.
• W2801288565 cites W2140952049 @default.
• W2801288565 cites W2142890842 @default.
• W2801288565 cites W2144410236 @default.
• W2801288565 cites W2157288342 @default.
• W2801288565 cites W2160975634 @default.
• W2801288565 cites W2166898290 @default.
• W2801288565 cites W2167852161 @default.
• W2801288565 cites W2233881958 @default.
• W2801288565 cites W2256694280 @default.
• W2801288565 cites W2259938310 @default.
• W2801288565 cites W2311203695 @default.
• W2801288565 cites W2333286569 @default.
• W2801288565 cites W2514798099 @default.
• W2801288565 cites W2525387128 @default.
• W2801288565 cites W2533855169 @default.
• W2801288565 cites W2534005127 @default.
• W2801288565 doi "https://doi.org/10.1371/journal.pgen.1007311" @default.
• W2801288565 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5908061" @default.
• W2801288565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29672586" @default.
• W2801288565 hasPublicationYear "2018" @default.
• W2801288565 type Work @default.
• W2801288565 sameAs 2801288565 @default.
• W2801288565 citedByCount "6" @default.
• W2801288565 countsByYear W28012885652018 @default.
• W2801288565 countsByYear W28012885652019 @default.
• W2801288565 countsByYear W28012885652020 @default.
• W2801288565 countsByYear W28012885652022 @default.
• W2801288565 crossrefType "journal-article" @default.
• W2801288565 hasAuthorship W2801288565A5001892334 @default.
• W2801288565 hasAuthorship W2801288565A5002416298 @default.
• W2801288565 hasAuthorship W2801288565A5004301892 @default.
• W2801288565 hasAuthorship W2801288565A5007947168 @default.
• W2801288565 hasAuthorship W2801288565A5011542020 @default.
• W2801288565 hasAuthorship W2801288565A5046383405 @default.
• W2801288565 hasAuthorship W2801288565A5053251909 @default.
• W2801288565 hasAuthorship W2801288565A5079759086 @default.
• W2801288565 hasAuthorship W2801288565A5080217028 @default.
• W2801288565 hasAuthorship W2801288565A5084213906 @default.
• W2801288565 hasBestOaLocation W28012885651 @default.

• next