FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801296051> ?p ?o ?g. }

• W2801296051 endingPage "52" @default.
• W2801296051 startingPage "52" @default.
• W2801296051 abstract "Chronic myeloid leukaemia (CML) is caused by the BCR-ABL oncogene, which encodes the constitutively active BCR-ABL tyrosine kinase. Targeted therapy with tyrosine-kinase inhibitors induces a partial cytogenetic response in most patients. Nanosystems can represent an opportunity for combinatorial therapy with the capacity to simultaneously release different therapeutic agents, checking the pharmacokinetic properties. In this work, we have developed a novel poly-(ε-caprolactone) (PCL) nanosystem for combinatorial therapy in CML, composed of a biodegradable pH sensitive core releasing Nilotinib (Nil) and an enzymatic sensitive outer shell releasing Imatinib Mesylate (IM), resulting in wool-like nanoparticles (NPs). The resulting double loaded wool-like hollow PCL NPs showed a high dual-drug encapsulation efficiency, pH and enzymatic sensitivity and synchronized drug release capability. The combinatorial delivery of IM and Nil exhibited an importantly reduced IC50 value of IM and Nil on leukaemia cells compared to single free drugs administration. In vitro results, showed that combinatorial nanomixures preserved the biological activity of loaded drugs for extensive time windows and led to a constant release of active drug. In addition, the combination of IM and Nil in single PCL NPs have shown a more therapeutic efficiency at a low dose with respect to the single drug nanomixures, confirming that both drugs reached the target cell precisely, maximizing the cytotoxicity while minimizing the chances of cell resistance to drugs." @default.
• W2801296051 created "2018-05-17" @default.
• W2801296051 creator A5026619272 @default.
• W2801296051 creator A5034052273 @default.
• W2801296051 creator A5064411130 @default.
• W2801296051 date "2018-04-18" @default.
• W2801296051 modified "2023-09-30" @default.
• W2801296051 title "Wool-Like Hollow Polymeric Nanoparticles for CML Chemo-Combinatorial Therapy" @default.
• W2801296051 cites W120419820 @default.
• W2801296051 cites W1969553679 @default.
• W2801296051 cites W1981238513 @default.
• W2801296051 cites W1982884759 @default.
• W2801296051 cites W1991611141 @default.
• W2801296051 cites W1998325814 @default.
• W2801296051 cites W1998380582 @default.
• W2801296051 cites W1999614615 @default.
• W2801296051 cites W2005496979 @default.
• W2801296051 cites W2011240957 @default.
• W2801296051 cites W2011626144 @default.
• W2801296051 cites W2015616444 @default.
• W2801296051 cites W2015704490 @default.
• W2801296051 cites W2016258885 @default.
• W2801296051 cites W2022050193 @default.
• W2801296051 cites W2035264169 @default.
• W2801296051 cites W2037041572 @default.
• W2801296051 cites W2038915916 @default.
• W2801296051 cites W2047271327 @default.
• W2801296051 cites W2051160517 @default.
• W2801296051 cites W2057410741 @default.
• W2801296051 cites W2065061214 @default.
• W2801296051 cites W2066484074 @default.
• W2801296051 cites W2073798076 @default.
• W2801296051 cites W2077945404 @default.
• W2801296051 cites W2079793032 @default.
• W2801296051 cites W2082601713 @default.
• W2801296051 cites W2083928750 @default.
• W2801296051 cites W2088110670 @default.
• W2801296051 cites W2090450679 @default.
• W2801296051 cites W2092500155 @default.
• W2801296051 cites W2097732752 @default.
• W2801296051 cites W2097946794 @default.
• W2801296051 cites W2108036428 @default.
• W2801296051 cites W2124196948 @default.
• W2801296051 cites W2139107535 @default.
• W2801296051 cites W2140169865 @default.
• W2801296051 cites W2140873245 @default.
• W2801296051 cites W2149841510 @default.
• W2801296051 cites W2164452916 @default.
• W2801296051 cites W2165537263 @default.
• W2801296051 cites W2166152877 @default.
• W2801296051 cites W2166459210 @default.
• W2801296051 cites W2169678660 @default.
• W2801296051 cites W2170952917 @default.
• W2801296051 cites W2170975933 @default.
• W2801296051 cites W2171330302 @default.
• W2801296051 cites W2184534421 @default.
• W2801296051 cites W2267613418 @default.
• W2801296051 cites W2273495465 @default.
• W2801296051 cites W2312667966 @default.
• W2801296051 cites W2317901346 @default.
• W2801296051 cites W2404933325 @default.
• W2801296051 cites W2621566172 @default.
• W2801296051 doi "https://doi.org/10.3390/pharmaceutics10020052" @default.
• W2801296051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6027521" @default.
• W2801296051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29670043" @default.
• W2801296051 hasPublicationYear "2018" @default.
• W2801296051 type Work @default.
• W2801296051 sameAs 2801296051 @default.
• W2801296051 citedByCount "15" @default.
• W2801296051 countsByYear W28012960512019 @default.
• W2801296051 countsByYear W28012960512020 @default.
• W2801296051 countsByYear W28012960512021 @default.
• W2801296051 countsByYear W28012960512022 @default.
• W2801296051 countsByYear W28012960512023 @default.
• W2801296051 crossrefType "journal-article" @default.
• W2801296051 hasAuthorship W2801296051A5026619272 @default.
• W2801296051 hasAuthorship W2801296051A5034052273 @default.
• W2801296051 hasAuthorship W2801296051A5064411130 @default.
• W2801296051 hasBestOaLocation W28012960511 @default.
• W2801296051 hasConcept C170493617 @default.
• W2801296051 hasConcept C178790620 @default.
• W2801296051 hasConcept C18150654 @default.
• W2801296051 hasConcept C185592680 @default.
• W2801296051 hasConcept C2777413986 @default.
• W2801296051 hasConcept C2777583451 @default.
• W2801296051 hasConcept C2778729363 @default.
• W2801296051 hasConcept C2779820397 @default.
• W2801296051 hasConcept C2780035454 @default.
• W2801296051 hasConcept C3019892230 @default.
• W2801296051 hasConcept C42362537 @default.
• W2801296051 hasConcept C502942594 @default.
• W2801296051 hasConcept C55493867 @default.
• W2801296051 hasConcept C71924100 @default.
• W2801296051 hasConcept C98274493 @default.
• W2801296051 hasConceptScore W2801296051C170493617 @default.
• W2801296051 hasConceptScore W2801296051C178790620 @default.
• W2801296051 hasConceptScore W2801296051C18150654 @default.
• W2801296051 hasConceptScore W2801296051C185592680 @default.

• next