Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801301059> ?p ?o ?g. }
- W2801301059 endingPage "113" @default.
- W2801301059 startingPage "99" @default.
- W2801301059 abstract "In the present study, a novel dry small interfering RNA (siRNA) powder for inhalation, containing polyethyleneimine (PEI) as a delivery vector, was produced by spray freeze drying (SFD). The powder had spherical and highly porous structure of approximately 10 μm in diameter with high aerosol performance for emission and lung delivery. The reconstituted siRNA/PEI complex after dissolution of the powder had almost the same physicochemical properties and in vitro gene silencing activity as the original one constituted in the sample solution before SFD, showing that the integrity of the siRNA was maintained. In in vivo studies of intratracheal administration into lung metastasis mice and healthy mice, powder with a low dose of 3 μg siRNA exhibited strong and specific gene silencing activity against tumors metastasized to the lungs, whereas it caused no significant histological changes, lactate dehydrogenase leakage, or inflammatory cytokine induction in the lungs. These results strongly indicated that inhalable dry siRNA/PEI powders can provide effective pulmonary gene silencing without severe lung injury and that SFD can be applied to the production of such powders." @default.
- W2801301059 created "2018-05-17" @default.
- W2801301059 creator A5004310701 @default.
- W2801301059 creator A5006069954 @default.
- W2801301059 creator A5019544664 @default.
- W2801301059 creator A5049047228 @default.
- W2801301059 creator A5063947325 @default.
- W2801301059 creator A5082859565 @default.
- W2801301059 date "2018-06-01" @default.
- W2801301059 modified "2023-10-14" @default.
- W2801301059 title "Development of spray-freeze-dried siRNA/PEI powder for inhalation with high aerosol performance and strong pulmonary gene silencing activity" @default.
- W2801301059 cites W1611419331 @default.
- W2801301059 cites W1677881169 @default.
- W2801301059 cites W1968400683 @default.
- W2801301059 cites W1971090348 @default.
- W2801301059 cites W1983222220 @default.
- W2801301059 cites W1985117052 @default.
- W2801301059 cites W1988878632 @default.
- W2801301059 cites W2003359605 @default.
- W2801301059 cites W2004909226 @default.
- W2801301059 cites W2011989381 @default.
- W2801301059 cites W2017341540 @default.
- W2801301059 cites W2019510161 @default.
- W2801301059 cites W2025634182 @default.
- W2801301059 cites W2029720457 @default.
- W2801301059 cites W2030270093 @default.
- W2801301059 cites W2046440988 @default.
- W2801301059 cites W2051226833 @default.
- W2801301059 cites W2054616259 @default.
- W2801301059 cites W2060774518 @default.
- W2801301059 cites W2061752094 @default.
- W2801301059 cites W2065176007 @default.
- W2801301059 cites W2069856721 @default.
- W2801301059 cites W2075075421 @default.
- W2801301059 cites W2079195911 @default.
- W2801301059 cites W2079840724 @default.
- W2801301059 cites W2086424019 @default.
- W2801301059 cites W2089669803 @default.
- W2801301059 cites W2091453255 @default.
- W2801301059 cites W2093940404 @default.
- W2801301059 cites W2102581008 @default.
- W2801301059 cites W2112135623 @default.
- W2801301059 cites W2127654256 @default.
- W2801301059 cites W2139228713 @default.
- W2801301059 cites W2152376500 @default.
- W2801301059 cites W2156732206 @default.
- W2801301059 cites W2158221216 @default.
- W2801301059 cites W2165591105 @default.
- W2801301059 cites W2190142705 @default.
- W2801301059 cites W2235198151 @default.
- W2801301059 cites W2237314194 @default.
- W2801301059 cites W2291888757 @default.
- W2801301059 cites W2325171920 @default.
- W2801301059 cites W2519532943 @default.
- W2801301059 cites W2523101278 @default.
- W2801301059 doi "https://doi.org/10.1016/j.jconrel.2018.04.003" @default.
- W2801301059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29627404" @default.
- W2801301059 hasPublicationYear "2018" @default.
- W2801301059 type Work @default.
- W2801301059 sameAs 2801301059 @default.
- W2801301059 citedByCount "47" @default.
- W2801301059 countsByYear W28013010592018 @default.
- W2801301059 countsByYear W28013010592019 @default.
- W2801301059 countsByYear W28013010592020 @default.
- W2801301059 countsByYear W28013010592021 @default.
- W2801301059 countsByYear W28013010592022 @default.
- W2801301059 countsByYear W28013010592023 @default.
- W2801301059 crossrefType "journal-article" @default.
- W2801301059 hasAuthorship W2801301059A5004310701 @default.
- W2801301059 hasAuthorship W2801301059A5006069954 @default.
- W2801301059 hasAuthorship W2801301059A5019544664 @default.
- W2801301059 hasAuthorship W2801301059A5049047228 @default.
- W2801301059 hasAuthorship W2801301059A5063947325 @default.
- W2801301059 hasAuthorship W2801301059A5082859565 @default.
- W2801301059 hasConcept C104317684 @default.
- W2801301059 hasConcept C105702510 @default.
- W2801301059 hasConcept C119056186 @default.
- W2801301059 hasConcept C126322002 @default.
- W2801301059 hasConcept C150903083 @default.
- W2801301059 hasConcept C153911025 @default.
- W2801301059 hasConcept C181199279 @default.
- W2801301059 hasConcept C185592680 @default.
- W2801301059 hasConcept C202751555 @default.
- W2801301059 hasConcept C207001950 @default.
- W2801301059 hasConcept C22615655 @default.
- W2801301059 hasConcept C2776954882 @default.
- W2801301059 hasConcept C2777318727 @default.
- W2801301059 hasConcept C2777714996 @default.
- W2801301059 hasConcept C502942594 @default.
- W2801301059 hasConcept C55493867 @default.
- W2801301059 hasConcept C67705224 @default.
- W2801301059 hasConcept C71924100 @default.
- W2801301059 hasConcept C86803240 @default.
- W2801301059 hasConcept C98274493 @default.
- W2801301059 hasConceptScore W2801301059C104317684 @default.
- W2801301059 hasConceptScore W2801301059C105702510 @default.
- W2801301059 hasConceptScore W2801301059C119056186 @default.
- W2801301059 hasConceptScore W2801301059C126322002 @default.