FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801301313> ?p ?o ?g. }

• W2801301313 endingPage "5052" @default.
• W2801301313 startingPage "5042" @default.
• W2801301313 abstract "The molecular mechanism of long-term memory has been extensively studied in the context of the hippocampus-dependent recent memory examined within several days. However, months-old remote memory maintained in the cortex for long-term has not been investigated much at the molecular level yet. Various epigenetic mechanisms are known to be important for long-term memory, but how the 3D chromatin architecture and its regulator molecules contribute to neuronal plasticity and systems consolidation is still largely unknown. CCCTC-binding factor (CTCF) is an 11-zinc finger protein well known for its role as a genome architecture molecule. Male conditional knock-out mice in which CTCF is lost in excitatory neurons during adulthood showed normal recent memory in the contextual fear conditioning and spatial water maze tasks. However, they showed remarkable impairments in remote memory in both tasks. Underlying the remote memory-specific phenotypes, we observed that female CTCF conditional knock-out mice exhibit disrupted cortical LTP, but not hippocampal LTP. Similarly, we observed that CTCF deletion in inhibitory neurons caused partial impairment of remote memory. Through RNA sequencing, we observed that CTCF knockdown in cortical neuron culture caused altered expression of genes that are highly involved in cell adhesion, synaptic plasticity, and memory. These results suggest that remote memory storage in the cortex requires CTCF-mediated gene regulation in neurons, whereas recent memory formation in the hippocampus does not. SIGNIFICANCE STATEMENT CCCTC-binding factor (CTCF) is a well-known 3D genome architectural protein that regulates gene expression. Here, we use two different CTCF conditional knock-out mouse lines and reveal, for the first time, that CTCF is critically involved in the regulation of remote memory. We also show that CTCF is necessary for appropriate expression of genes, many of which we found to be involved in the learning- and memory-related processes. Our study provides behavioral and physiological evidence for the involvement of CTCF-mediated gene regulation in the remote long-term memory and elucidates our understanding of systems consolidation mechanisms." @default.
• W2801301313 created "2018-05-17" @default.
• W2801301313 creator A5002245392 @default.
• W2801301313 creator A5026542089 @default.
• W2801301313 creator A5032935203 @default.
• W2801301313 creator A5034040962 @default.
• W2801301313 creator A5034936407 @default.
• W2801301313 creator A5036081806 @default.
• W2801301313 creator A5037167277 @default.
• W2801301313 creator A5037561393 @default.
• W2801301313 creator A5049064713 @default.
• W2801301313 creator A5051414465 @default.
• W2801301313 creator A5057449622 @default.
• W2801301313 creator A5062197224 @default.
• W2801301313 creator A5065045333 @default.
• W2801301313 creator A5068993400 @default.
• W2801301313 creator A5072645451 @default.
• W2801301313 creator A5086729399 @default.
• W2801301313 date "2018-04-30" @default.
• W2801301313 modified "2023-10-14" @default.
• W2801301313 title "Remote Memory and Cortical Synaptic Plasticity Require Neuronal CCCTC-Binding Factor (CTCF)" @default.
• W2801301313 cites W1483057098 @default.
• W2801301313 cites W1699926620 @default.
• W2801301313 cites W1924378360 @default.
• W2801301313 cites W1941076503 @default.
• W2801301313 cites W1966116114 @default.
• W2801301313 cites W1972346280 @default.
• W2801301313 cites W1979526394 @default.
• W2801301313 cites W1984827465 @default.
• W2801301313 cites W1998271864 @default.
• W2801301313 cites W1999574084 @default.
• W2801301313 cites W2013152269 @default.
• W2801301313 cites W2013934108 @default.
• W2801301313 cites W2022127465 @default.
• W2801301313 cites W2024758252 @default.
• W2801301313 cites W2029722028 @default.
• W2801301313 cites W2032607393 @default.
• W2801301313 cites W2034145329 @default.
• W2801301313 cites W2038148830 @default.
• W2801301313 cites W2047743009 @default.
• W2801301313 cites W2070509435 @default.
• W2801301313 cites W2073789350 @default.
• W2801301313 cites W2079381434 @default.
• W2801301313 cites W2089817334 @default.
• W2801301313 cites W2098682209 @default.
• W2801301313 cites W2103017472 @default.
• W2801301313 cites W2107032654 @default.
• W2801301313 cites W2108167859 @default.
• W2801301313 cites W2110513111 @default.
• W2801301313 cites W2114104545 @default.
• W2801301313 cites W2115986753 @default.
• W2801301313 cites W2124649657 @default.
• W2801301313 cites W2127497792 @default.
• W2801301313 cites W2129617921 @default.
• W2801301313 cites W2131453083 @default.
• W2801301313 cites W2132533498 @default.
• W2801301313 cites W2133659563 @default.
• W2801301313 cites W2134861134 @default.
• W2801301313 cites W2157057741 @default.
• W2801301313 cites W2157468016 @default.
• W2801301313 cites W2159279126 @default.
• W2801301313 cites W2172174991 @default.
• W2801301313 cites W2264646417 @default.
• W2801301313 cites W2507461348 @default.
• W2801301313 cites W2530292798 @default.
• W2801301313 cites W2554495435 @default.
• W2801301313 cites W2570294420 @default.
• W2801301313 cites W2756900458 @default.
• W2801301313 cites W2758121911 @default.
• W2801301313 cites W2779066263 @default.
• W2801301313 cites W4252232449 @default.
• W2801301313 doi "https://doi.org/10.1523/jneurosci.2738-17.2018" @default.
• W2801301313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6705941" @default.
• W2801301313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29712785" @default.
• W2801301313 hasPublicationYear "2018" @default.
• W2801301313 type Work @default.
• W2801301313 sameAs 2801301313 @default.
• W2801301313 citedByCount "37" @default.
• W2801301313 countsByYear W28013013132018 @default.
• W2801301313 countsByYear W28013013132019 @default.
• W2801301313 countsByYear W28013013132020 @default.
• W2801301313 countsByYear W28013013132021 @default.
• W2801301313 countsByYear W28013013132022 @default.
• W2801301313 countsByYear W28013013132023 @default.
• W2801301313 crossrefType "journal-article" @default.
• W2801301313 hasAuthorship W2801301313A5002245392 @default.
• W2801301313 hasAuthorship W2801301313A5026542089 @default.
• W2801301313 hasAuthorship W2801301313A5032935203 @default.
• W2801301313 hasAuthorship W2801301313A5034040962 @default.
• W2801301313 hasAuthorship W2801301313A5034936407 @default.
• W2801301313 hasAuthorship W2801301313A5036081806 @default.
• W2801301313 hasAuthorship W2801301313A5037167277 @default.
• W2801301313 hasAuthorship W2801301313A5037561393 @default.
• W2801301313 hasAuthorship W2801301313A5049064713 @default.
• W2801301313 hasAuthorship W2801301313A5051414465 @default.
• W2801301313 hasAuthorship W2801301313A5057449622 @default.
• W2801301313 hasAuthorship W2801301313A5062197224 @default.
• W2801301313 hasAuthorship W2801301313A5065045333 @default.

• next