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• W2801302557 abstract "Due to advances in medical imaging, computational fluid dynamics algorithms and high performance computing, computer simulation is developing into an important tool for understanding the relationship between cardiovascular diseases and intraventricular blood flow. The field of cardiac flow simulation is challenging and highly interdisciplinary. We apply a computational framework for automated solutions of partial differential equations using Finite Element Methods where any mathematical description directly can be translated to code. This allows us to develop a cardiac model where specific properties of the heart such as fluid-structure interaction of the aortic valve can be added in a modular way without extensive efforts. In previous work, we simulated the blood flow in the left ventricle of the heart. In this paper, we extend this model by placing prototypes of both a native and a mechanical aortic valve in the outflow region of the left ventricle. Numerical simulation of the blood flow in the vicinity of the valve offers the possibility to improve the treatment of aortic valve diseases as aortic stenosis (narrowing of the valve opening) or regurgitation (leaking) and to optimize the design of prosthetic heart valves in a controlled and specific way. The fluid-structure interaction and contact problem are formulated in a unified continuum model using the conservation laws for mass and momentum and a phase function. The discretization is based on an Arbitrary Lagrangian-Eulerian space-time finite element method with streamline diffusion stabilization, and it is implemented in the open source software Unicorn which shows near optimal scaling up to thousands of cores. Computational results are presented to demonstrate the capability of our framework." @default.
• W2801302557 created "2018-05-17" @default.
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• W2801302557 date "2018-04-16" @default.
• W2801302557 modified "2023-10-18" @default.
• W2801302557 title "3D Fluid-Structure Interaction Simulation of Aortic Valves Using a Unified Continuum ALE FEM Model" @default.
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• W2801302557 doi "https://doi.org/10.3389/fphys.2018.00363" @default.
• W2801302557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5911501" @default.
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