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- W2801320847 abstract "Abstract Titanium dioxide nanoparticles (TiO 2 NPs) are among abundantly used metal oxide NPs but their interactions with biomolecules and subsequent embryonic toxicity in higher vertebrates is not extensively reported. Physicochemical interactions of TiO 2 NPs with egg albumen reveals that lower doses of TiO 2 NPs (10 and 25 µg/ml) accounted for higher friccohesity and activation energy but an increment in molecular radii was recorded at higher doses (50 and 100 µg/ml). FTIR analysis revealed conformational changes in secondary structure of egg albumen as a result of electrostratic interactions between egg albumen and TiO 2 NPs. The morphometric data of chicken embryo recorded a reduction at all the doses of TiO 2 NPs, but toxicity and developmental deformity (omphalocele and flexed limbs) were recorded at lower doses only. Inductively coupled plasma optical emission spectrometry (ICP-OES) confirmed presence of Ti in chicken embryos. mRNA levels of genes involved in canonical and non-canonical Wnt signaling were lowered following TiO 2 NPs treatment resulting in free radical mediated disruption of lateral plate mesoderm and somite myogenesis. Conformational changes in egg albumen and subsequent developmental deformity in chicken embryo following TiO 2 NPs treatment warrants detailed studies of NP toxicity at lower doses prior to their biomedical applications." @default.
- W2801320847 created "2018-05-17" @default.
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- W2801320847 date "2018-03-19" @default.
- W2801320847 modified "2023-10-12" @default.
- W2801320847 title "TiO2 nanoparticles induce omphalocele in chicken embryo by disrupting Wnt signaling pathway" @default.
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- W2801320847 doi "https://doi.org/10.1038/s41598-018-23215-7" @default.
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