FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801332034> ?p ?o ?g. }

• W2801332034 endingPage "1088" @default.
• W2801332034 startingPage "1075" @default.
• W2801332034 abstract "Growing evidence suggests that mitochondrial dysfunction is an early event in sporadic Alzheimer’s disease (AD), but the impact of mitochondrial dysfunction on the transition from healthy aging to AD remains elusive. Here we estimated the influence of mitochondrial dysfunction on the initiation of AD signs in OXYS rats, which simulate key characteristics of sporadic AD. We assessed the mitochondrial ultrastructure of pyramidal neurons of the hippocampus at the age preceding the development (age 20 days), during manifestation (4–5 months), and at the well-pronounced stages (18–24 months) of the AD-like pathology in OXYS rats. Ultrastructural alterations were collated with the amounts of proteins mediating mitochondrial dynamics [mitofusins (MFN1 and MFN2) and dynamin-1-like protein (DRP1)]; with activity of respiratory chain complexes I, IV, and V in the hippocampal mitochondria; with reactive oxygen species (ROS) production; and with expression of uncoupling protein 2 (UCP2) regulating ROS production. Already at the preclinical stage, OXYS rats showed some characteristic changes in hippocampal mitochondria, which increased in size with the manifestation and progression of AD-like pathology, including decreased activity of respiratory complexes against the background of greater fusion and formation of larger mitochondria. Signs of AD developed simultaneously with increasing dysfunction of mitochondria, with a dramatic decrease in their number, and with increased fission but without upregulation of ROS production (observed only in 20-day-old OXYS rats). Summarizing the data from our present and previous studies, we conclude that mitochondrial dysfunction appears to mediate or possibly even initiate pathological molecular cascades of AD-like pathology in OXYS rats and can be considered a predictor of the early development of the late-onset form of AD in humans." @default.
• W2801332034 created "2018-05-17" @default.
• W2801332034 creator A5002019350 @default.
• W2801332034 creator A5005719344 @default.
• W2801332034 creator A5013470804 @default.
• W2801332034 creator A5022968854 @default.
• W2801332034 creator A5030568682 @default.
• W2801332034 creator A5088920906 @default.
• W2801332034 creator A5091671474 @default.
• W2801332034 date "2018-05-08" @default.
• W2801332034 modified "2023-10-16" @default.
• W2801332034 title "Mitochondrial Dysfunction as a Predictor and Driver of Alzheimer’s Disease-Like Pathology in OXYS Rats" @default.
• W2801332034 cites W100463330 @default.
• W2801332034 cites W1525966131 @default.
• W2801332034 cites W1600722043 @default.
• W2801332034 cites W1629059403 @default.
• W2801332034 cites W1643376448 @default.
• W2801332034 cites W1712017471 @default.
• W2801332034 cites W1899652908 @default.
• W2801332034 cites W1964365626 @default.
• W2801332034 cites W1971980150 @default.
• W2801332034 cites W1975090760 @default.
• W2801332034 cites W1978582104 @default.
• W2801332034 cites W1979048203 @default.
• W2801332034 cites W1985977889 @default.
• W2801332034 cites W2003627315 @default.
• W2801332034 cites W2004129180 @default.
• W2801332034 cites W2017155042 @default.
• W2801332034 cites W2033885016 @default.
• W2801332034 cites W2036573181 @default.
• W2801332034 cites W2038006225 @default.
• W2801332034 cites W2049366846 @default.
• W2801332034 cites W2053318915 @default.
• W2801332034 cites W2058567239 @default.
• W2801332034 cites W2074052524 @default.
• W2801332034 cites W2106177167 @default.
• W2801332034 cites W2107600848 @default.
• W2801332034 cites W2108482197 @default.
• W2801332034 cites W2112802413 @default.
• W2801332034 cites W2117692658 @default.
• W2801332034 cites W2150994390 @default.
• W2801332034 cites W2166131107 @default.
• W2801332034 cites W2173281420 @default.
• W2801332034 cites W2294557246 @default.
• W2801332034 cites W2399232837 @default.
• W2801332034 cites W2471519258 @default.
• W2801332034 cites W2528945162 @default.
• W2801332034 cites W2560251144 @default.
• W2801332034 cites W2584978674 @default.
• W2801332034 cites W2586648405 @default.
• W2801332034 cites W2604387140 @default.
• W2801332034 cites W2615397447 @default.
• W2801332034 cites W2626841948 @default.
• W2801332034 cites W2704196653 @default.
• W2801332034 cites W2780539753 @default.
• W2801332034 cites W2783356125 @default.
• W2801332034 cites W4241020690 @default.
• W2801332034 cites W4246228772 @default.
• W2801332034 cites W604196653 @default.
• W2801332034 doi "https://doi.org/10.3233/jad-180065" @default.
• W2801332034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29710722" @default.
• W2801332034 hasPublicationYear "2018" @default.
• W2801332034 type Work @default.
• W2801332034 sameAs 2801332034 @default.
• W2801332034 citedByCount "31" @default.
• W2801332034 countsByYear W28013320342018 @default.
• W2801332034 countsByYear W28013320342019 @default.
• W2801332034 countsByYear W28013320342020 @default.
• W2801332034 countsByYear W28013320342021 @default.
• W2801332034 countsByYear W28013320342022 @default.
• W2801332034 countsByYear W28013320342023 @default.
• W2801332034 crossrefType "journal-article" @default.
• W2801332034 hasAuthorship W2801332034A5002019350 @default.
• W2801332034 hasAuthorship W2801332034A5005719344 @default.
• W2801332034 hasAuthorship W2801332034A5013470804 @default.
• W2801332034 hasAuthorship W2801332034A5022968854 @default.
• W2801332034 hasAuthorship W2801332034A5030568682 @default.
• W2801332034 hasAuthorship W2801332034A5088920906 @default.
• W2801332034 hasAuthorship W2801332034A5091671474 @default.
• W2801332034 hasConcept C104317684 @default.
• W2801332034 hasConcept C126322002 @default.
• W2801332034 hasConcept C127561419 @default.
• W2801332034 hasConcept C134018914 @default.
• W2801332034 hasConcept C148762608 @default.
• W2801332034 hasConcept C163950672 @default.
• W2801332034 hasConcept C17619807 @default.
• W2801332034 hasConcept C24586158 @default.
• W2801332034 hasConcept C2777092462 @default.
• W2801332034 hasConcept C2777591492 @default.
• W2801332034 hasConcept C2779134260 @default.
• W2801332034 hasConcept C2781161787 @default.
• W2801332034 hasConcept C28859421 @default.
• W2801332034 hasConcept C48349386 @default.
• W2801332034 hasConcept C502032728 @default.
• W2801332034 hasConcept C55493867 @default.
• W2801332034 hasConcept C71924100 @default.
• W2801332034 hasConcept C86803240 @default.
• W2801332034 hasConcept C95444343 @default.

• next