FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801338314> ?p ?o ?g. }

• W2801338314 abstract "Heart failure (HF) is highly prevalent and associated with high mortality in chronic kidney disease (CKD). Although the cardiac structural alterations in CKD had been well studied, the pathophysiology of cardiac dysfunction in CKD, especially in the early asymptomatic stage, is not well understood. Identification of early cardiac dysfunction and an understanding of the pathophysiology of such dysfunction are vital in preventing the emergence and progression of HF in CKD. The hypothesis underlying this thesis is that CPOmax (peak cardiac power output) and cardiac functional reserve are impaired in asymptomatic CKD patients even in the absence of any known cardiac diseases or diabetes. Asymptomatic CKD patients without primary cardiac diseases or diabetes mellitus were tested. CPOmax, a direct indicator of cardiac performance, was measured non-invasively using specialised cardiopulmonary exercise test. In addition, the reversibility of subclinical cardiac dysfunction after kidney transplantation was evaluated. Furthermore, to obtain mechanistic insights, the relationship between subclinical cardiac dysfunction and serum uraemic toxin concentrations, and the direct effect of a prototype uraemic toxin on the mechanical properties of isolated rodent cardiomyocytes were also evaluated.Compared to healthy controls, the CKD patients showed a graded reduction in CPOmax across different stages of CKD. The impairment was found to be reversible with kidney transplantation. The impairment correlated with total and free serum concentrations of indoxyl sulphate (IXS), a protein bound uraemic toxin. Further in vitro evaluation showed that IXS had direct physiological effects on cardiomyocytes and was shown to act through pathway involving protein kinase-A akin to the mechanism of action of sympathomimetics. In conclusion, this reverse translational research has demonstrated for the first time that CKD per se causes impairment of peak cardiac power output and thereby cardiac functional reserve in vivo, and unravelled a novel mechanism of cardiotoxicity mediated by a protein-bound uraemic toxin in vitro." @default.
• W2801338314 created "2018-05-17" @default.
• W2801338314 creator A5047196877 @default.
• W2801338314 date "2017-07-01" @default.
• W2801338314 modified "2023-09-23" @default.
• W2801338314 title "Evaluation of Cardiac Dysfunction in Patients with Chronic Kidney Disease" @default.
• W2801338314 cites W1035375854 @default.
• W2801338314 cites W1489755771 @default.
• W2801338314 cites W1506251539 @default.
• W2801338314 cites W152197594 @default.
• W2801338314 cites W1530472930 @default.
• W2801338314 cites W1543589545 @default.
• W2801338314 cites W1865202788 @default.
• W2801338314 cites W1890288585 @default.
• W2801338314 cites W1963799075 @default.
• W2801338314 cites W1965700291 @default.
• W2801338314 cites W1965899716 @default.
• W2801338314 cites W1967995087 @default.
• W2801338314 cites W1972253696 @default.
• W2801338314 cites W1973641847 @default.
• W2801338314 cites W1977633093 @default.
• W2801338314 cites W1979517335 @default.
• W2801338314 cites W1979773090 @default.
• W2801338314 cites W1981364249 @default.
• W2801338314 cites W1981374368 @default.
• W2801338314 cites W1983663722 @default.
• W2801338314 cites W1983898476 @default.
• W2801338314 cites W1984393349 @default.
• W2801338314 cites W1985540047 @default.
• W2801338314 cites W1985756426 @default.
• W2801338314 cites W1991509112 @default.
• W2801338314 cites W1991796998 @default.
• W2801338314 cites W1992458635 @default.
• W2801338314 cites W1996978408 @default.
• W2801338314 cites W2000204073 @default.
• W2801338314 cites W2001972347 @default.
• W2801338314 cites W2001984572 @default.
• W2801338314 cites W2004289384 @default.
• W2801338314 cites W2005741206 @default.
• W2801338314 cites W2009730285 @default.
• W2801338314 cites W2011862587 @default.
• W2801338314 cites W2015668150 @default.
• W2801338314 cites W2020239768 @default.
• W2801338314 cites W2021315555 @default.
• W2801338314 cites W2022073078 @default.
• W2801338314 cites W2024559429 @default.
• W2801338314 cites W2025106435 @default.
• W2801338314 cites W2025562052 @default.
• W2801338314 cites W2026617871 @default.
• W2801338314 cites W2029070953 @default.
• W2801338314 cites W2029777615 @default.
• W2801338314 cites W2029785070 @default.
• W2801338314 cites W2031941775 @default.
• W2801338314 cites W2032576629 @default.
• W2801338314 cites W2033820059 @default.
• W2801338314 cites W2034563271 @default.
• W2801338314 cites W2037598467 @default.
• W2801338314 cites W2038623844 @default.
• W2801338314 cites W2041725636 @default.
• W2801338314 cites W2044483758 @default.
• W2801338314 cites W2044727076 @default.
• W2801338314 cites W2047040800 @default.
• W2801338314 cites W2049739776 @default.
• W2801338314 cites W2050477993 @default.
• W2801338314 cites W2050824263 @default.
• W2801338314 cites W2051474827 @default.
• W2801338314 cites W2052412268 @default.
• W2801338314 cites W2052780003 @default.
• W2801338314 cites W2055068804 @default.
• W2801338314 cites W2055534323 @default.
• W2801338314 cites W2055864845 @default.
• W2801338314 cites W2058298934 @default.
• W2801338314 cites W2058399710 @default.
• W2801338314 cites W2060200294 @default.
• W2801338314 cites W2060804509 @default.
• W2801338314 cites W2061535011 @default.
• W2801338314 cites W2064657449 @default.
• W2801338314 cites W2065464983 @default.
• W2801338314 cites W2066523471 @default.
• W2801338314 cites W2068593790 @default.
• W2801338314 cites W2072315403 @default.
• W2801338314 cites W2073789348 @default.
• W2801338314 cites W2077267814 @default.
• W2801338314 cites W2079498453 @default.
• W2801338314 cites W2080731721 @default.
• W2801338314 cites W2083313568 @default.
• W2801338314 cites W2086368799 @default.
• W2801338314 cites W2087036791 @default.
• W2801338314 cites W2089365655 @default.
• W2801338314 cites W2089695853 @default.
• W2801338314 cites W2091161602 @default.
• W2801338314 cites W2091867363 @default.
• W2801338314 cites W2093535053 @default.
• W2801338314 cites W2095689312 @default.
• W2801338314 cites W2096099020 @default.
• W2801338314 cites W2096352923 @default.
• W2801338314 cites W2097324029 @default.
• W2801338314 cites W2097350481 @default.
• W2801338314 cites W2097969657 @default.
• W2801338314 cites W2099290548 @default.

• next