Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801352681> ?p ?o ?g. }
- W2801352681 abstract "Abstract Disorders of N-linked glycosylation are increasingly reported in the literature. However, targets responsible for the associated developmental and physiological defects are largely unknown. Bone Morphogenetic Proteins (BMPs) act as highly dynamic complexes to regulate several functions during development. The range and strength of BMP activity depend on interactions with glycosylated protein complexes in the extracellular milieu. Here we investigate the role of glycosylation for the function of the conserved extracellular BMP antagonist Short gastrulation (Sog). We identify conserved N-glycosylated sites and describe the effect of mutating these residues on BMP pathway activity in Drosophila. Functional analysis reveals that loss of individual Sog glycosylation sites enhances BMP antagonism and/or increases the spatial range of Sog effects in the tissue. Mechanistically, we provide evidence that N-terminal and stem glycosylation controls extracellular Sog levels and distribution. The identification of similar residues in vertebrate Chordin proteins suggests that N-glycosylation may be an evolutionarily conserved process that adds complexity to the regulation of BMP activity. Summary Statement N-glycosylation restricts the function of Short gastrulation during Drosophila development by controlling the amount of extracellular protein. This adds another layer of complexity to regulation of Bone Morphogenetic Protein signals." @default.
- W2801352681 created "2018-05-17" @default.
- W2801352681 creator A5020994299 @default.
- W2801352681 creator A5034112168 @default.
- W2801352681 creator A5036453207 @default.
- W2801352681 creator A5044815568 @default.
- W2801352681 creator A5046044324 @default.
- W2801352681 creator A5060070957 @default.
- W2801352681 creator A5078023227 @default.
- W2801352681 creator A5082847599 @default.
- W2801352681 creator A5083390477 @default.
- W2801352681 date "2018-05-07" @default.
- W2801352681 modified "2023-09-27" @default.
- W2801352681 title "N-linked glycosylation of the antagonist Short gastrulation increases the functional complexity of BMP signals" @default.
- W2801352681 cites W1435682058 @default.
- W2801352681 cites W1534052611 @default.
- W2801352681 cites W1603468729 @default.
- W2801352681 cites W1756591279 @default.
- W2801352681 cites W1842953786 @default.
- W2801352681 cites W1852286056 @default.
- W2801352681 cites W1884276191 @default.
- W2801352681 cites W1941585788 @default.
- W2801352681 cites W1964480763 @default.
- W2801352681 cites W1968263279 @default.
- W2801352681 cites W1972509609 @default.
- W2801352681 cites W1976830636 @default.
- W2801352681 cites W1980950773 @default.
- W2801352681 cites W1984011890 @default.
- W2801352681 cites W1993953064 @default.
- W2801352681 cites W2012244893 @default.
- W2801352681 cites W2012794478 @default.
- W2801352681 cites W2015279698 @default.
- W2801352681 cites W2028213428 @default.
- W2801352681 cites W2028605179 @default.
- W2801352681 cites W2030956358 @default.
- W2801352681 cites W2033470490 @default.
- W2801352681 cites W2035375262 @default.
- W2801352681 cites W2037611829 @default.
- W2801352681 cites W2043045303 @default.
- W2801352681 cites W2050545087 @default.
- W2801352681 cites W2053108921 @default.
- W2801352681 cites W2055233872 @default.
- W2801352681 cites W2065976288 @default.
- W2801352681 cites W2066643493 @default.
- W2801352681 cites W2066914760 @default.
- W2801352681 cites W2069467774 @default.
- W2801352681 cites W2073168778 @default.
- W2801352681 cites W2074782098 @default.
- W2801352681 cites W2089312361 @default.
- W2801352681 cites W2089421579 @default.
- W2801352681 cites W2099975379 @default.
- W2801352681 cites W2107819345 @default.
- W2801352681 cites W2115340713 @default.
- W2801352681 cites W2116716503 @default.
- W2801352681 cites W2119251208 @default.
- W2801352681 cites W2121875967 @default.
- W2801352681 cites W2122023582 @default.
- W2801352681 cites W2122447210 @default.
- W2801352681 cites W2124219423 @default.
- W2801352681 cites W2124937388 @default.
- W2801352681 cites W2126900218 @default.
- W2801352681 cites W2127450691 @default.
- W2801352681 cites W2127580647 @default.
- W2801352681 cites W2130458631 @default.
- W2801352681 cites W2137389347 @default.
- W2801352681 cites W2139743386 @default.
- W2801352681 cites W2139818451 @default.
- W2801352681 cites W2145976440 @default.
- W2801352681 cites W2147451371 @default.
- W2801352681 cites W2147547186 @default.
- W2801352681 cites W2149605631 @default.
- W2801352681 cites W2151170075 @default.
- W2801352681 cites W2156767851 @default.
- W2801352681 cites W2157261826 @default.
- W2801352681 cites W2162409772 @default.
- W2801352681 cites W2177942679 @default.
- W2801352681 cites W2187500434 @default.
- W2801352681 cites W2188229030 @default.
- W2801352681 cites W2254075920 @default.
- W2801352681 cites W2511931567 @default.
- W2801352681 cites W2731464816 @default.
- W2801352681 cites W2754486903 @default.
- W2801352681 cites W4249890897 @default.
- W2801352681 cites W980126877 @default.
- W2801352681 doi "https://doi.org/10.1101/316448" @default.
- W2801352681 hasPublicationYear "2018" @default.
- W2801352681 type Work @default.
- W2801352681 sameAs 2801352681 @default.
- W2801352681 citedByCount "0" @default.
- W2801352681 crossrefType "posted-content" @default.
- W2801352681 hasAuthorship W2801352681A5020994299 @default.
- W2801352681 hasAuthorship W2801352681A5034112168 @default.
- W2801352681 hasAuthorship W2801352681A5036453207 @default.
- W2801352681 hasAuthorship W2801352681A5044815568 @default.
- W2801352681 hasAuthorship W2801352681A5046044324 @default.
- W2801352681 hasAuthorship W2801352681A5060070957 @default.
- W2801352681 hasAuthorship W2801352681A5078023227 @default.
- W2801352681 hasAuthorship W2801352681A5082847599 @default.
- W2801352681 hasAuthorship W2801352681A5083390477 @default.
- W2801352681 hasBestOaLocation W28013526811 @default.