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• W2801352747 abstract "Abstract An ethanol extract from Veratrum lobelianum Bernh. rhizomes showed larvicidal activity with LC 50 values of 11.79 ppm and 89.9 ppm against 1 st and 4 th instar larvae, respectively, at 24 h post-treatment. The extract also showed proportion not biting (PNB) value of 0.76 at 100 μg/cm 2 against females of Ae . aegypti . Systematic bioassay-guided fractionation of V . lobelianum extract resulted in the isolation of five compounds that were identified as ethyl palmitate ( 1 ), ethyl linoleate ( 2 ), β-sitosterol ( 3 ), resveratrol ( 4 ) and oxyresveratrol ( 5 ) by GC-MS, 1 H-NMR, and 13 C-NMR techniques, comparison with literature data, and confirmation with authentic compounds. Compound 2 exhibited larvicidal activity with an LC 50 value of 24.1 (22.0-26.2) ppm whereas 1 was inactive. β-Sitosterol ( 3 ) displayed the highest larvicidal activity with LC 50 = 1.7 (1.3-12.3) ppm and LC 90 = 5.1 (3.4-13.8) ppm. Compounds 4 and 5 had larvicidal activity with LC 50 values of 18.5 (15.3-23.3) and 22.6 (19.0-26.8) ppm, respectively, and had an equivalent PNB values of 0.75 at 25 nmol/cm 2 . In addition, 4 and 5 were explored for their human-based repellency against Ae . aegypti , attractiveness against male medflies Ceratitis capitata , and also evaluated against series of human carcinoma cells (A549, HEK293, HeLa, SH-SY5Y); however, no significant activity was found." @default.
• W2801352747 created "2018-05-17" @default.
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• W2801352747 date "2018-01-01" @default.
• W2801352747 modified "2023-10-18" @default.
• W2801352747 title "Bioassay-guided isolation and identification of <i>Aedes aegypti</i> larvicidal and biting deterrent compounds from <i>Veratrum lobelianum</i>" @default.
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• W2801352747 doi "https://doi.org/10.1515/chem-2018-0030" @default.
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