Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801354291> ?p ?o ?g. }
- W2801354291 endingPage "77" @default.
- W2801354291 startingPage "66" @default.
- W2801354291 abstract "Cholesterol plays a vital role in modulating the action of membrane proteins critical to cellular function. The effect of serum cholesterol on the prognosis of hepatocellular carcinoma (HCC) patients remains uncertain. Here, we report that high levels of cholesterol predict good survival and low disease recurrence after surgery. Cholesterol could significantly suppress migration and invasion of HCC cells and restrain metastasis of HCC in mice. High levels of cholesterol promoted CD44 translocation into lipid rafts and attenuated CD44-Ezrin binding, which are crucial for cell migration and cancer metastasis. The suppressive effect of cholesterol on HCC metastasis was abolished by the downregulation of CD44 or its palmitoylation inhibitor, which blocked CD44 localization in lipid rafts. Furthermore, pharmacologically promoting CD44 retention inside lipid rafts obviously attenuated HCC migration and invasion, providing a potential therapeutic strategy to prolong the survival of HCC patients." @default.
- W2801354291 created "2018-05-17" @default.
- W2801354291 creator A5042624998 @default.
- W2801354291 creator A5047932271 @default.
- W2801354291 creator A5066869574 @default.
- W2801354291 creator A5078768332 @default.
- W2801354291 creator A5080930329 @default.
- W2801354291 creator A5085483595 @default.
- W2801354291 creator A5085809876 @default.
- W2801354291 creator A5087848665 @default.
- W2801354291 creator A5090984012 @default.
- W2801354291 date "2018-08-01" @default.
- W2801354291 modified "2023-10-15" @default.
- W2801354291 title "Cholesterol inhibits hepatocellular carcinoma invasion and metastasis by promoting CD44 localization in lipid rafts" @default.
- W2801354291 cites W1533747850 @default.
- W2801354291 cites W1973006797 @default.
- W2801354291 cites W1973880931 @default.
- W2801354291 cites W2010542459 @default.
- W2801354291 cites W2013444952 @default.
- W2801354291 cites W2024060067 @default.
- W2801354291 cites W2031455995 @default.
- W2801354291 cites W2032860037 @default.
- W2801354291 cites W2038225686 @default.
- W2801354291 cites W2054558479 @default.
- W2801354291 cites W2062706926 @default.
- W2801354291 cites W2069605409 @default.
- W2801354291 cites W2071533902 @default.
- W2801354291 cites W2072128091 @default.
- W2801354291 cites W2080100349 @default.
- W2801354291 cites W2084991860 @default.
- W2801354291 cites W2097124947 @default.
- W2801354291 cites W2101375502 @default.
- W2801354291 cites W2112902326 @default.
- W2801354291 cites W2133406172 @default.
- W2801354291 cites W2133650808 @default.
- W2801354291 cites W2138331892 @default.
- W2801354291 cites W2148287035 @default.
- W2801354291 cites W2149255929 @default.
- W2801354291 cites W2155407283 @default.
- W2801354291 cites W2169620068 @default.
- W2801354291 cites W2299840252 @default.
- W2801354291 cites W2313545945 @default.
- W2801354291 cites W2555385098 @default.
- W2801354291 cites W2563820872 @default.
- W2801354291 cites W2736708878 @default.
- W2801354291 cites W2742596986 @default.
- W2801354291 cites W2746697572 @default.
- W2801354291 cites W2772889643 @default.
- W2801354291 cites W4245784696 @default.
- W2801354291 cites W4321429512 @default.
- W2801354291 doi "https://doi.org/10.1016/j.canlet.2018.04.038" @default.
- W2801354291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29746928" @default.
- W2801354291 hasPublicationYear "2018" @default.
- W2801354291 type Work @default.
- W2801354291 sameAs 2801354291 @default.
- W2801354291 citedByCount "54" @default.
- W2801354291 countsByYear W28013542912018 @default.
- W2801354291 countsByYear W28013542912019 @default.
- W2801354291 countsByYear W28013542912020 @default.
- W2801354291 countsByYear W28013542912021 @default.
- W2801354291 countsByYear W28013542912022 @default.
- W2801354291 countsByYear W28013542912023 @default.
- W2801354291 crossrefType "journal-article" @default.
- W2801354291 hasAuthorship W2801354291A5042624998 @default.
- W2801354291 hasAuthorship W2801354291A5047932271 @default.
- W2801354291 hasAuthorship W2801354291A5066869574 @default.
- W2801354291 hasAuthorship W2801354291A5078768332 @default.
- W2801354291 hasAuthorship W2801354291A5080930329 @default.
- W2801354291 hasAuthorship W2801354291A5085483595 @default.
- W2801354291 hasAuthorship W2801354291A5085809876 @default.
- W2801354291 hasAuthorship W2801354291A5087848665 @default.
- W2801354291 hasAuthorship W2801354291A5090984012 @default.
- W2801354291 hasConcept C104317684 @default.
- W2801354291 hasConcept C121608353 @default.
- W2801354291 hasConcept C126322002 @default.
- W2801354291 hasConcept C127561419 @default.
- W2801354291 hasConcept C1491633281 @default.
- W2801354291 hasConcept C2778019345 @default.
- W2801354291 hasConcept C2778163477 @default.
- W2801354291 hasConcept C2779013556 @default.
- W2801354291 hasConcept C2780932548 @default.
- W2801354291 hasConcept C502942594 @default.
- W2801354291 hasConcept C55493867 @default.
- W2801354291 hasConcept C71924100 @default.
- W2801354291 hasConcept C79266657 @default.
- W2801354291 hasConcept C86803240 @default.
- W2801354291 hasConceptScore W2801354291C104317684 @default.
- W2801354291 hasConceptScore W2801354291C121608353 @default.
- W2801354291 hasConceptScore W2801354291C126322002 @default.
- W2801354291 hasConceptScore W2801354291C127561419 @default.
- W2801354291 hasConceptScore W2801354291C1491633281 @default.
- W2801354291 hasConceptScore W2801354291C2778019345 @default.
- W2801354291 hasConceptScore W2801354291C2778163477 @default.
- W2801354291 hasConceptScore W2801354291C2779013556 @default.
- W2801354291 hasConceptScore W2801354291C2780932548 @default.
- W2801354291 hasConceptScore W2801354291C502942594 @default.
- W2801354291 hasConceptScore W2801354291C55493867 @default.
- W2801354291 hasConceptScore W2801354291C71924100 @default.