FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801355086> ?p ?o ?g. }

• W2801355086 abstract "Background: MDMA (Ecstasy; 3, 4-methylenedioxymethylamphetamine), an illicit drug that has been increasingly abused by young people, affects target organs including reproductive system induced by oxidative stress. In biological systems, lipid peroxidation is probably reduced effectively by Vitamin E, a strong antioxidant inhibiting free radicals. Objectives: The current study was an attempt to assess the protective effects of Vitamin E on serum biochemical indices and sperm quality parameters in MDMA treated mice. Materials and Methods: In the present study, 28 male albino mice were randomly assigned to four equal groups. Group 1 (control) received saline by gastric gavage and i.p.; Group 2 (MDMA) received MDMA (10 mg/kg) i.p. and saline by gastric gavage; Group 3 (MDMA + Vitamin E) received MDMA (10 mg/kg) i.p.and vitamin E (150 mg/kg) by gastric gavage; and Group 4 (olive oil) received virgin olive oil (150 mg/kg) by gastric gavage and saline i.p. MDMA was injected with single daily dose, three sequential days/week for 5 weeks (35 days). Blood samples were collected, and then the animals were sacrificed by cervical dislocation. Animals’ cauda epididymis were dissected and used for analyzing and evaluating sperm parameters including sperm count, motility, viability, DNA damage, nuclear maturation, and sperm morphology. Results: Comparison of the MDMA group with the other groups indicated a significant (P < 0.05) decrease in total antioxidant capacity (TAC) and sperm parameters including sperm count, motility, viability, nuclear maturation, and sperm morphology. A significant increase (P < 0.05) was observed in the malondialdehyde (MDA) and percentage of sperm with DNA damage of the MDMA group compared to the other groups. We observed a significant increase (P < 0.05) in TAC and sperm parameters including sperm count, motility, viability, nuclear maturation, and sperm morphology along with a significant decrease (P < 0.05) in MDA and DNA sperm damage in the MDMA + Vit E group compared to the MDMA group. While, the MDMA+Vit E group showed a significant decrease (P < 0.05) in sperm motility, sperm morphology, and viability along with a significant increase (P < 0.05) in DNA sperm damage and nuclear maturation compared to the control group. TAC, MDA, and sperm count study showed no significant difference when compared to the control group. Conclusions: The results of the present study showed that MDMA caused induced toxicity in sperm parameters, reduced TAC, and increased MDA level. However, Vitamin E was proven to decrease effectively the deleterious and harmful effects of MDMA on sperm parameters." @default.
• W2801355086 created "2018-05-17" @default.
• W2801355086 creator A5003437122 @default.
• W2801355086 creator A5008270105 @default.
• W2801355086 creator A5050849841 @default.
• W2801355086 creator A5060976845 @default.
• W2801355086 creator A5086891261 @default.
• W2801355086 creator A5088526701 @default.
• W2801355086 date "2017-11-11" @default.
• W2801355086 modified "2023-10-01" @default.
• W2801355086 title "The Effects of Vitamin E on Prevention of Damages Due to MDMA (Ecstasy) Exposure on Sperm Parameters in Mice" @default.
• W2801355086 cites W1964219332 @default.
• W2801355086 cites W1966575277 @default.
• W2801355086 cites W1967041220 @default.
• W2801355086 cites W1975258598 @default.
• W2801355086 cites W1994144122 @default.
• W2801355086 cites W1995610565 @default.
• W2801355086 cites W1996571869 @default.
• W2801355086 cites W1998434519 @default.
• W2801355086 cites W1999779609 @default.
• W2801355086 cites W2003730063 @default.
• W2801355086 cites W2011360219 @default.
• W2801355086 cites W2022566604 @default.
• W2801355086 cites W2035759859 @default.
• W2801355086 cites W2036982675 @default.
• W2801355086 cites W2037475158 @default.
• W2801355086 cites W2040815296 @default.
• W2801355086 cites W2048593368 @default.
• W2801355086 cites W2059100986 @default.
• W2801355086 cites W2068950939 @default.
• W2801355086 cites W2074448366 @default.
• W2801355086 cites W2081137234 @default.
• W2801355086 cites W2097798808 @default.
• W2801355086 cites W2101413923 @default.
• W2801355086 cites W2125869037 @default.
• W2801355086 cites W2127354625 @default.
• W2801355086 cites W2133451731 @default.
• W2801355086 cites W2138700431 @default.
• W2801355086 cites W2149140181 @default.
• W2801355086 cites W2159160564 @default.
• W2801355086 cites W2161506037 @default.
• W2801355086 cites W2168439614 @default.
• W2801355086 cites W2171638979 @default.
• W2801355086 cites W2269030057 @default.
• W2801355086 cites W2275274443 @default.
• W2801355086 cites W2395880234 @default.
• W2801355086 cites W2428826819 @default.
• W2801355086 cites W2552276365 @default.
• W2801355086 cites W2558309727 @default.
• W2801355086 cites W4239672867 @default.
• W2801355086 doi "https://doi.org/10.5812/ijhrba.63205" @default.
• W2801355086 hasPublicationYear "2017" @default.
• W2801355086 type Work @default.
• W2801355086 sameAs 2801355086 @default.
• W2801355086 citedByCount "1" @default.
• W2801355086 countsByYear W28013550862023 @default.
• W2801355086 crossrefType "journal-article" @default.
• W2801355086 hasAuthorship W2801355086A5003437122 @default.
• W2801355086 hasAuthorship W2801355086A5008270105 @default.
• W2801355086 hasAuthorship W2801355086A5050849841 @default.
• W2801355086 hasAuthorship W2801355086A5060976845 @default.
• W2801355086 hasAuthorship W2801355086A5086891261 @default.
• W2801355086 hasAuthorship W2801355086A5088526701 @default.
• W2801355086 hasBestOaLocation W28013550861 @default.
• W2801355086 hasConcept C118552586 @default.
• W2801355086 hasConcept C126322002 @default.
• W2801355086 hasConcept C16685009 @default.
• W2801355086 hasConcept C185592680 @default.
• W2801355086 hasConcept C2776151105 @default.
• W2801355086 hasConcept C2777397205 @default.
• W2801355086 hasConcept C2777551382 @default.
• W2801355086 hasConcept C2777632594 @default.
• W2801355086 hasConcept C2778004101 @default.
• W2801355086 hasConcept C2778401633 @default.
• W2801355086 hasConcept C2779488553 @default.
• W2801355086 hasConcept C2780829032 @default.
• W2801355086 hasConcept C2780876324 @default.
• W2801355086 hasConcept C2781087480 @default.
• W2801355086 hasConcept C2781254305 @default.
• W2801355086 hasConcept C55493867 @default.
• W2801355086 hasConcept C71924100 @default.
• W2801355086 hasConcept C98274493 @default.
• W2801355086 hasConceptScore W2801355086C118552586 @default.
• W2801355086 hasConceptScore W2801355086C126322002 @default.
• W2801355086 hasConceptScore W2801355086C16685009 @default.
• W2801355086 hasConceptScore W2801355086C185592680 @default.
• W2801355086 hasConceptScore W2801355086C2776151105 @default.
• W2801355086 hasConceptScore W2801355086C2777397205 @default.
• W2801355086 hasConceptScore W2801355086C2777551382 @default.
• W2801355086 hasConceptScore W2801355086C2777632594 @default.
• W2801355086 hasConceptScore W2801355086C2778004101 @default.
• W2801355086 hasConceptScore W2801355086C2778401633 @default.
• W2801355086 hasConceptScore W2801355086C2779488553 @default.
• W2801355086 hasConceptScore W2801355086C2780829032 @default.
• W2801355086 hasConceptScore W2801355086C2780876324 @default.
• W2801355086 hasConceptScore W2801355086C2781087480 @default.
• W2801355086 hasConceptScore W2801355086C2781254305 @default.
• W2801355086 hasConceptScore W2801355086C55493867 @default.
• W2801355086 hasConceptScore W2801355086C71924100 @default.
• W2801355086 hasConceptScore W2801355086C98274493 @default.

• next