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- W2801356309 abstract "Proteasome inhibitors have changed the treatment landscape for multiple myeloma and are being increasingly used in the treatment of lymphoma; however, patients eventually have progressive disease and development resistance to treatment. Multiple unique mechanisms of resistance have been identified, and they are unified by reducing a cell’s sensitivity to endoplasmic reticulum stress either from changes intrinsic to the cancer cell or extrinsic to the cancer cell and due to changes in the microenvironment. These pathways primarily involve upregulation of proteasome subunits increasing the capacity to degrade unfolded proteins and plasmacytic differentiation to a more immature plasma cell phenotype with reduced immunoglobulin production. Understanding these mechanisms of resistance can inform therapeutic options to reverse drug resistance or use of novel combinations to synergistically target the unfolded protein response pathway." @default.
- W2801356309 created "2018-05-17" @default.
- W2801356309 creator A5030726651 @default.
- W2801356309 creator A5067141626 @default.
- W2801356309 date "2018-01-01" @default.
- W2801356309 modified "2023-09-27" @default.
- W2801356309 title "Proteasome Inhibitors with a Focus on Bortezomib" @default.
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