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- W2801367002 abstract "Yeast mutants deficient in x-ray- and ultraviolet light (uv)-induced mitotic heteroallelic reversion, were isolated from disomic cells. Of ten identified mutants, seven were studied in detail. The mutants exhibited depressed frequencies of x-ray- and/or uv-induced reversion in the heteroallelic region arg4-2 +/+ arg4-17 on disomic chromosome VIII. Two of the mutants are x-ray sensitive and one is both x-ray and uv sensitive. The remaining four strains exhibited wild-type response to both radiations. Six of the mutations segregated as one recessive gene. Complementation and allelism tests were performed and a minimum of four genes, denoted rec1, rec2, rec3, and rec4 were identified among these six mutations. It is suggested, by analogy with results obtained in E. coli, that induced lesions in DNA serve as substrate for recombination, while rec mutants are unable to complete the steps required for exchange. Wild-type sensitivity to radiation-induced damage in four mutants suggests that recombination in yeas..." @default.
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- W2801367002 date "1972-01-01" @default.
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- W2801367002 title "Radiation-induced recombination in Saccharomyces: isolation and genetic study of recombination-deficient mutants." @default.
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