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• W2801385478 abstract "The aims of this study were to establish optimal doses of doxycycline (dox) against Haemophilus parasuis on the basis of pharmacokinetic–pharmacodynamic ( PK ‐ PD ) integration modeling. The infected model was established by intranasal inoculation of organism in pigs and confirmed by clinical signs, blood biochemistry, and microscopic examinations. The recommended dose (20 mg/kg b.w.) was administered in pigs through intramuscular routes for PK studies. The area under the concentration 0‐ to 24‐hr curve ( AUC 0–24 ), elimination half‐life ( T ½ke ), and mean residence time ( MRT ) of dox in healthy and H. parasuis ‐infected pigs were 55.51 ± 5.72 versus 57.10 ± 4.89 μg·hr/ml, 8.28 ± 0.91 versus 9.80 ± 2.38 hr, and 8.43 ± 0.27 versus 8.79 ± 0.18 hr, respectively. The minimal inhibitory concentration ( MIC ) of dox against 40 H. parasuis isolates was conducted through broth microdilution method, the corresponding MIC 50 and MIC 90 were 0.25 and 1 μg/ ml , respectively. The Ex vivo growth inhibition data suggested that dox exhibited a concentration‐dependent killing mechanism. Based on the observed AUC 24 hr / MIC values by modeling PK ‐ PD data in H. parasuis ‐infected pigs, the doses predicted to obtain bacteriostatic, bactericidal, and elimination effects for H. parasuis over 24 hr were 5.25, 8.55, and 10.37 mg/kg for the 50% target attainment rate ( TAR ), and 7.26, 13.82, and 18.17 mg/kg for 90% TAR , respectively. This study provided a more optimized alternative for clinical use and demonstrated that the dosage 20 mg/kg of dox by intramuscular administration could have an effective bactericidal activity against H. parasuis ." @default.
• W2801385478 created "2018-05-17" @default.
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• W2801385478 date "2018-04-25" @default.
• W2801385478 modified "2023-10-15" @default.
• W2801385478 title "Integration of pharmacokinetic-pharmacodynamic for dose optimization of doxycycline against <i>Haemophilus parasuis</i> in pigs" @default.
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• W2801385478 doi "https://doi.org/10.1111/jvp.12512" @default.
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