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• W2801386863 abstract "Streptoseomycin (1), which is a rare macrodilactone with potent activities against microaerophilic bacteria, featuring a pentacyclic 5/14/10/6/6 ring system together with an ether bridge, was characterized by a combination of spectroscopic method and X-ray analysis from a marine Streptomyces seoulensis. Sequencing and characterization of a ∼76-kb biosynthetic gene cluster led to the proposition of the biosynthetic pathway of 1. Heterologous expression of the gene cluster using a BAC vector in Streptomyces chartreusis 1018 led to the successful production of 1." @default.
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• W2801386863 date "2018-04-26" @default.
• W2801386863 modified "2023-10-18" @default.
• W2801386863 title "Discovery, Biosynthesis, and Heterologous Production of Streptoseomycin, an Anti-Microaerophilic Bacteria Macrodilactone" @default.
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• W2801386863 doi "https://doi.org/10.1021/acs.orglett.8b01006" @default.
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