FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801387089> ?p ?o ?g. }

• W2801387089 abstract "MicroRNAs(miRNAs)are involved in the initiation and progression of hepatocellular carcinoma. ESC, an extract of Stellerachamaejasme L, had been confirmed as a potential anti-tumor extract of Traditional Chinese Medicine. In light of the important role of miRNAs in hepatocellular carcinoma, we questioned whether the inhibitory effects of ESC on hepatocellular carcinoma (HCC) were associated with miRNAs. The proliferation inhibition of ESC on HCC cells was measured with MTT assay. The migration inhibition of ESC on HCC cells was measured with transwell assay. The influences of ESC on growth and metastasis inhibition were evaluated with xenograft tumor model of HCC. Protein expressions were measured with western blot and immunofluorescence methods and miRNA profiles were detected with miRNA array. Differential miRNA and target mRNAs were verified with real-time PCR. The results showed that ESC could inhibit proliferation and epithelial mesenchymal transition (EMT) in HCC cells in vitro and tumor growth and metastasis in xenograft models in vivo. miRNA array results showed that 69 differential miRNAs in total of 429 ones were obtained in MHCC97H cells treated by ESC. hsa-miR-107, hsa-miR-638, hsa-miR-106b-5p were selected to be validated with real-time PCR method in HepG2 and MHCC97H cells. Expressions of hsa-miR-107 and hsa-miR-638 increased obviously in HCC cells treated by ESC. Target genes of three miRNAs were also validated with real-time PCR. Interestingly, only target genes of hsa-miR-107 changed greatly. ESC downregulated the MCL1, SALL4 and BCL2 gene expressions significantly but did not influence the expression of CACNA2D1. The findings suggested ESC regressed growth and metastasis of human hepatocellular carcinoma via regulating microRNAs expression and their corresponding target genes." @default.
• W2801387089 created "2018-05-17" @default.
• W2801387089 creator A5002379932 @default.
• W2801387089 creator A5035520440 @default.
• W2801387089 creator A5054684639 @default.
• W2801387089 creator A5071772212 @default.
• W2801387089 creator A5079183814 @default.
• W2801387089 creator A5083399144 @default.
• W2801387089 creator A5086360069 @default.
• W2801387089 date "2018-03-20" @default.
• W2801387089 modified "2023-09-27" @default.
• W2801387089 title "Extract of Stellerachamaejasme L(ESC) inhibits growth and metastasis of human hepatocellular carcinoma via regulating microRNA expression" @default.
• W2801387089 cites W1488879331 @default.
• W2801387089 cites W1550861967 @default.
• W2801387089 cites W1799601486 @default.
• W2801387089 cites W1852362934 @default.
• W2801387089 cites W1895649416 @default.
• W2801387089 cites W1927005984 @default.
• W2801387089 cites W1971054810 @default.
• W2801387089 cites W1971831496 @default.
• W2801387089 cites W1975672932 @default.
• W2801387089 cites W1978826626 @default.
• W2801387089 cites W1979798177 @default.
• W2801387089 cites W1994450509 @default.
• W2801387089 cites W2021703812 @default.
• W2801387089 cites W2030857870 @default.
• W2801387089 cites W2035527366 @default.
• W2801387089 cites W2037264543 @default.
• W2801387089 cites W2037916822 @default.
• W2801387089 cites W2040587605 @default.
• W2801387089 cites W2041134486 @default.
• W2801387089 cites W2045069460 @default.
• W2801387089 cites W2054583743 @default.
• W2801387089 cites W2061943812 @default.
• W2801387089 cites W2062299145 @default.
• W2801387089 cites W2069639704 @default.
• W2801387089 cites W2075616704 @default.
• W2801387089 cites W2077312273 @default.
• W2801387089 cites W2082316306 @default.
• W2801387089 cites W2087837402 @default.
• W2801387089 cites W2115754362 @default.
• W2801387089 cites W2123650356 @default.
• W2801387089 cites W2131640859 @default.
• W2801387089 cites W2139292037 @default.
• W2801387089 cites W2141297251 @default.
• W2801387089 cites W2151993669 @default.
• W2801387089 cites W2153301608 @default.
• W2801387089 cites W2154493509 @default.
• W2801387089 cites W2162674813 @default.
• W2801387089 cites W2171303204 @default.
• W2801387089 cites W2176014506 @default.
• W2801387089 cites W2184586321 @default.
• W2801387089 cites W2191462165 @default.
• W2801387089 cites W2294901556 @default.
• W2801387089 cites W2408110481 @default.
• W2801387089 cites W2474415077 @default.
• W2801387089 cites W770461898 @default.
• W2801387089 cites W980451204 @default.
• W2801387089 doi "https://doi.org/10.1186/s12906-018-2123-y" @default.
• W2801387089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5859742" @default.
• W2801387089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29554896" @default.
• W2801387089 hasPublicationYear "2018" @default.
• W2801387089 type Work @default.
• W2801387089 sameAs 2801387089 @default.
• W2801387089 citedByCount "11" @default.
• W2801387089 countsByYear W28013870892018 @default.
• W2801387089 countsByYear W28013870892019 @default.
• W2801387089 countsByYear W28013870892020 @default.
• W2801387089 countsByYear W28013870892021 @default.
• W2801387089 countsByYear W28013870892022 @default.
• W2801387089 countsByYear W28013870892023 @default.
• W2801387089 crossrefType "journal-article" @default.
• W2801387089 hasAuthorship W2801387089A5002379932 @default.
• W2801387089 hasAuthorship W2801387089A5035520440 @default.
• W2801387089 hasAuthorship W2801387089A5054684639 @default.
• W2801387089 hasAuthorship W2801387089A5071772212 @default.
• W2801387089 hasAuthorship W2801387089A5079183814 @default.
• W2801387089 hasAuthorship W2801387089A5083399144 @default.
• W2801387089 hasAuthorship W2801387089A5086360069 @default.
• W2801387089 hasBestOaLocation W28013870891 @default.
• W2801387089 hasConcept C104317684 @default.
• W2801387089 hasConcept C121608353 @default.
• W2801387089 hasConcept C126322002 @default.
• W2801387089 hasConcept C145059251 @default.
• W2801387089 hasConcept C153911025 @default.
• W2801387089 hasConcept C2776415932 @default.
• W2801387089 hasConcept C2778019345 @default.
• W2801387089 hasConcept C2779013556 @default.
• W2801387089 hasConcept C502942594 @default.
• W2801387089 hasConcept C55493867 @default.
• W2801387089 hasConcept C71924100 @default.
• W2801387089 hasConcept C76419328 @default.
• W2801387089 hasConcept C85265743 @default.
• W2801387089 hasConcept C86803240 @default.
• W2801387089 hasConceptScore W2801387089C104317684 @default.
• W2801387089 hasConceptScore W2801387089C121608353 @default.
• W2801387089 hasConceptScore W2801387089C126322002 @default.
• W2801387089 hasConceptScore W2801387089C145059251 @default.
• W2801387089 hasConceptScore W2801387089C153911025 @default.
• W2801387089 hasConceptScore W2801387089C2776415932 @default.

• next