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- W2801396520 abstract "Halogenation is commonly used in medicinal chemistry to improve the potency of pharmaceutical leads. While synthetic methods for halogenation present selectivity and reactivity challenges, halogenases have evolved over time to perform selective reactions under benign conditions. The optimization of halogenation biocatalysts has utilized enzyme evolution and structure-based engineering alongside biotransformation in a variety of systems to generate stable site-selective variants. The recent improvements in halogenase-catalyzed reactions has demonstrated the utility of these biocatalysts for industrial purposes, and their ability to achieve a broad substrate scope implies a synthetic tractability with increasing relevance in medicinal chemistry." @default.
- W2801396520 created "2018-05-17" @default.
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- W2801396520 date "2018-06-01" @default.
- W2801396520 modified "2023-10-03" @default.
- W2801396520 title "Halogenase engineering and its utility in medicinal chemistry" @default.
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- W2801396520 doi "https://doi.org/10.1016/j.bmcl.2018.04.066" @default.
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