FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801397654> ?p ?o ?g. }

• W2801397654 endingPage "644" @default.
• W2801397654 startingPage "636" @default.
• W2801397654 abstract "BackgroundEvidence supporting adjunctive corticosteroids during the treatment of Pneumocystis jirovecii pneumonia (PcP) in adults without HIV is minimal and controversial.MethodsThis retrospective cohort study included P jirovecii pneumonia-positive, hospitalized patients without HIV admitted to the Mayo Clinic from 2006 to 2016. Change from baseline in the respiratory component of the Sequential Organ Failure Assessment score (SOFAresp) at day 5 was compared between early (within 48 h) steroid recipients and nonrecipients by using multivariable logistic regression and in a propensity-matched analysis.ResultsAmong the 323 included patients (early steroids, n = 258; no steroids, n = 65), the median (interquartile range) age was 65 (53, 73) years, 63% were male, and 92% were white. Severity-adjusted regression and propensity-matched analyses found that early administration of steroids was associated with less improvement in SOFAresp at day 5 compared with no steroids (P = .001 and P = .017, respectively). No differences were observed in the odds of having at least a one-point improvement in SOFAresp at day 5 compared with baseline between groups (adjusted OR, 0.76 [95% CI, 0.24-2.28]; P = .61). Overall 30-day mortality was 22.9% (95% CI, 18.2-27.4). No differences in mortality, length of stay, admission to the ICU, or need for mechanical ventilation were found between early steroid recipients and nonrecipients.ConclusionsThe addition of early corticosteroids to anti-Pneumocystis therapy in patients without HIV was not associated with improved respiratory outcomes. Evidence supporting adjunctive corticosteroids during the treatment of Pneumocystis jirovecii pneumonia (PcP) in adults without HIV is minimal and controversial. This retrospective cohort study included P jirovecii pneumonia-positive, hospitalized patients without HIV admitted to the Mayo Clinic from 2006 to 2016. Change from baseline in the respiratory component of the Sequential Organ Failure Assessment score (SOFAresp) at day 5 was compared between early (within 48 h) steroid recipients and nonrecipients by using multivariable logistic regression and in a propensity-matched analysis. Among the 323 included patients (early steroids, n = 258; no steroids, n = 65), the median (interquartile range) age was 65 (53, 73) years, 63% were male, and 92% were white. Severity-adjusted regression and propensity-matched analyses found that early administration of steroids was associated with less improvement in SOFAresp at day 5 compared with no steroids (P = .001 and P = .017, respectively). No differences were observed in the odds of having at least a one-point improvement in SOFAresp at day 5 compared with baseline between groups (adjusted OR, 0.76 [95% CI, 0.24-2.28]; P = .61). Overall 30-day mortality was 22.9% (95% CI, 18.2-27.4). No differences in mortality, length of stay, admission to the ICU, or need for mechanical ventilation were found between early steroid recipients and nonrecipients. The addition of early corticosteroids to anti-Pneumocystis therapy in patients without HIV was not associated with improved respiratory outcomes." @default.
• W2801397654 created "2018-05-17" @default.
• W2801397654 creator A5013715545 @default.
• W2801397654 creator A5025259402 @default.
• W2801397654 creator A5036463140 @default.
• W2801397654 creator A5038835015 @default.
• W2801397654 creator A5042451395 @default.
• W2801397654 creator A5053804590 @default.
• W2801397654 creator A5054056429 @default.
• W2801397654 creator A5076903157 @default.
• W2801397654 date "2018-09-01" @default.
• W2801397654 modified "2023-10-03" @default.
• W2801397654 title "Early Corticosteroids for Pneumocystis Pneumonia in Adults Without HIV Are Not Associated With Better Outcome" @default.
• W2801397654 cites W10399549 @default.
• W2801397654 cites W1974576384 @default.
• W2801397654 cites W1974873560 @default.
• W2801397654 cites W1987092284 @default.
• W2801397654 cites W1999350359 @default.
• W2801397654 cites W2001638004 @default.
• W2801397654 cites W2009276775 @default.
• W2801397654 cites W2014353150 @default.
• W2801397654 cites W2059949727 @default.
• W2801397654 cites W2068230795 @default.
• W2801397654 cites W2071257400 @default.
• W2801397654 cites W2105078649 @default.
• W2801397654 cites W2111635289 @default.
• W2801397654 cites W2111643662 @default.
• W2801397654 cites W2121281175 @default.
• W2801397654 cites W2124326136 @default.
• W2801397654 cites W2124791110 @default.
• W2801397654 cites W2136975742 @default.
• W2801397654 cites W2141213079 @default.
• W2801397654 cites W2149000873 @default.
• W2801397654 cites W2162001089 @default.
• W2801397654 cites W2165282359 @default.
• W2801397654 cites W2468619793 @default.
• W2801397654 cites W2588456286 @default.
• W2801397654 cites W2597070792 @default.
• W2801397654 cites W4251876935 @default.
• W2801397654 doi "https://doi.org/10.1016/j.chest.2018.04.026" @default.
• W2801397654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29705221" @default.
• W2801397654 hasPublicationYear "2018" @default.
• W2801397654 type Work @default.
• W2801397654 sameAs 2801397654 @default.
• W2801397654 citedByCount "47" @default.
• W2801397654 countsByYear W28013976542018 @default.
• W2801397654 countsByYear W28013976542019 @default.
• W2801397654 countsByYear W28013976542020 @default.
• W2801397654 countsByYear W28013976542021 @default.
• W2801397654 countsByYear W28013976542022 @default.
• W2801397654 countsByYear W28013976542023 @default.
• W2801397654 crossrefType "journal-article" @default.
• W2801397654 hasAuthorship W2801397654A5013715545 @default.
• W2801397654 hasAuthorship W2801397654A5025259402 @default.
• W2801397654 hasAuthorship W2801397654A5036463140 @default.
• W2801397654 hasAuthorship W2801397654A5038835015 @default.
• W2801397654 hasAuthorship W2801397654A5042451395 @default.
• W2801397654 hasAuthorship W2801397654A5053804590 @default.
• W2801397654 hasAuthorship W2801397654A5054056429 @default.
• W2801397654 hasAuthorship W2801397654A5076903157 @default.
• W2801397654 hasConcept C119060515 @default.
• W2801397654 hasConcept C126322002 @default.
• W2801397654 hasConcept C167135981 @default.
• W2801397654 hasConcept C17923572 @default.
• W2801397654 hasConcept C2777160144 @default.
• W2801397654 hasConcept C2777559004 @default.
• W2801397654 hasConcept C2777914695 @default.
• W2801397654 hasConcept C71924100 @default.
• W2801397654 hasConceptScore W2801397654C119060515 @default.
• W2801397654 hasConceptScore W2801397654C126322002 @default.
• W2801397654 hasConceptScore W2801397654C167135981 @default.
• W2801397654 hasConceptScore W2801397654C17923572 @default.
• W2801397654 hasConceptScore W2801397654C2777160144 @default.
• W2801397654 hasConceptScore W2801397654C2777559004 @default.
• W2801397654 hasConceptScore W2801397654C2777914695 @default.
• W2801397654 hasConceptScore W2801397654C71924100 @default.
• W2801397654 hasIssue "3" @default.
• W2801397654 hasLocation W28013976541 @default.
• W2801397654 hasLocation W28013976542 @default.
• W2801397654 hasOpenAccess W2801397654 @default.
• W2801397654 hasPrimaryLocation W28013976541 @default.
• W2801397654 hasRelatedWork W1564819458 @default.
• W2801397654 hasRelatedWork W1841402711 @default.
• W2801397654 hasRelatedWork W1917306980 @default.
• W2801397654 hasRelatedWork W2001798019 @default.
• W2801397654 hasRelatedWork W2061253854 @default.
• W2801397654 hasRelatedWork W2102965974 @default.
• W2801397654 hasRelatedWork W2441906550 @default.
• W2801397654 hasRelatedWork W2733732621 @default.
• W2801397654 hasRelatedWork W2901135261 @default.
• W2801397654 hasRelatedWork W4200325928 @default.
• W2801397654 hasVolume "154" @default.
• W2801397654 isParatext "false" @default.
• W2801397654 isRetracted "false" @default.
• W2801397654 magId "2801397654" @default.
• W2801397654 workType "article" @default.