FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801400980> ?p ?o ?g. }

• W2801400980 abstract "Adult newborn hippocampal granule cells (abGCs) contribute to spatial learning and memory. abGCs are thought to play a specific role in pattern separation, distinct from developmentally born mature GCs (mGCs). Here we examine at which exact cell age abGCs are synaptically integrated into the adult network and which forms of synaptic plasticity are expressed in abGCs and mGCs. We used virus-mediated labeling of abGCs and mGCs to analyze changes in spine morphology as an indicator of plasticity in rats in vivo. High-frequency stimulation of the medial perforant path induced long-term potentiation in the middle molecular layer (MML) and long-term depression in the nonstimulated outer molecular layer (OML). This stimulation protocol elicited NMDA receptor-dependent homosynaptic spine enlargement in the MML and heterosynaptic spine shrinkage in the inner molecular layer and OML. Both processes were concurrently present on individual dendritic trees of abGCs and mGCs. Spine shrinkage counteracted spine enlargement and thus could play a homeostatic role, normalizing synaptic weights. Structural homosynaptic spine plasticity had a clear onset, appearing in abGCs by 28 d postinjection (dpi), followed by heterosynaptic spine plasticity at 35 dpi, and at 77 dpi was equally as present in mature abGCs as in mGCs. From 35 dpi on, about 60% of abGCs and mGCs showed significant homo- and heterosynaptic plasticity on the single-cell level. This demonstration of structural homo- and heterosynaptic plasticity in abGCs and mGCs defines the time course of the appearance of synaptic plasticity and integration for abGCs." @default.
• W2801400980 created "2018-05-17" @default.
• W2801400980 creator A5022907890 @default.
• W2801400980 creator A5033111523 @default.
• W2801400980 creator A5046801422 @default.
• W2801400980 creator A5059626898 @default.
• W2801400980 creator A5064688633 @default.
• W2801400980 creator A5072437547 @default.
• W2801400980 creator A5091234288 @default.
• W2801400980 date "2018-04-30" @default.
• W2801400980 modified "2023-10-16" @default.
• W2801400980 title "Structural homo- and heterosynaptic plasticity in mature and adult newborn rat hippocampal granule cells" @default.
• W2801400980 cites W1504248943 @default.
• W2801400980 cites W1590632482 @default.
• W2801400980 cites W1642619469 @default.
• W2801400980 cites W1675950512 @default.
• W2801400980 cites W1775494655 @default.
• W2801400980 cites W1966100863 @default.
• W2801400980 cites W1967222758 @default.
• W2801400980 cites W1970813148 @default.
• W2801400980 cites W1980574091 @default.
• W2801400980 cites W1981917260 @default.
• W2801400980 cites W1983226940 @default.
• W2801400980 cites W1983230142 @default.
• W2801400980 cites W1983553517 @default.
• W2801400980 cites W1986605182 @default.
• W2801400980 cites W1996434213 @default.
• W2801400980 cites W2000520243 @default.
• W2801400980 cites W2002112050 @default.
• W2801400980 cites W2005641938 @default.
• W2801400980 cites W2012438895 @default.
• W2801400980 cites W2036025389 @default.
• W2801400980 cites W2040653138 @default.
• W2801400980 cites W2047132334 @default.
• W2801400980 cites W2051173215 @default.
• W2801400980 cites W2061111257 @default.
• W2801400980 cites W2063466545 @default.
• W2801400980 cites W2074965724 @default.
• W2801400980 cites W2081150698 @default.
• W2801400980 cites W2082639285 @default.
• W2801400980 cites W2084652820 @default.
• W2801400980 cites W2085974955 @default.
• W2801400980 cites W2090312766 @default.
• W2801400980 cites W2093007839 @default.
• W2801400980 cites W2093807579 @default.
• W2801400980 cites W2094319585 @default.
• W2801400980 cites W2099614676 @default.
• W2801400980 cites W2107611011 @default.
• W2801400980 cites W2108557329 @default.
• W2801400980 cites W2108806144 @default.
• W2801400980 cites W2109197395 @default.
• W2801400980 cites W2110065479 @default.
• W2801400980 cites W2115290127 @default.
• W2801400980 cites W2120417084 @default.
• W2801400980 cites W2120811265 @default.
• W2801400980 cites W2120904988 @default.
• W2801400980 cites W2125095601 @default.
• W2801400980 cites W2131414754 @default.
• W2801400980 cites W2131693039 @default.
• W2801400980 cites W2134200856 @default.
• W2801400980 cites W2138147085 @default.
• W2801400980 cites W2160769038 @default.
• W2801400980 cites W2167279371 @default.
• W2801400980 cites W2326046674 @default.
• W2801400980 cites W2339526700 @default.
• W2801400980 cites W2418084819 @default.
• W2801400980 cites W2508335446 @default.
• W2801400980 cites W2769957205 @default.
• W2801400980 cites W4293029111 @default.
• W2801400980 doi "https://doi.org/10.1073/pnas.1801889115" @default.
• W2801400980 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5960324" @default.
• W2801400980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29712871" @default.
• W2801400980 hasPublicationYear "2018" @default.
• W2801400980 type Work @default.
• W2801400980 sameAs 2801400980 @default.
• W2801400980 citedByCount "29" @default.
• W2801400980 countsByYear W28014009802018 @default.
• W2801400980 countsByYear W28014009802019 @default.
• W2801400980 countsByYear W28014009802020 @default.
• W2801400980 countsByYear W28014009802021 @default.
• W2801400980 countsByYear W28014009802022 @default.
• W2801400980 countsByYear W28014009802023 @default.
• W2801400980 crossrefType "journal-article" @default.
• W2801400980 hasAuthorship W2801400980A5022907890 @default.
• W2801400980 hasAuthorship W2801400980A5033111523 @default.
• W2801400980 hasAuthorship W2801400980A5046801422 @default.
• W2801400980 hasAuthorship W2801400980A5059626898 @default.
• W2801400980 hasAuthorship W2801400980A5064688633 @default.
• W2801400980 hasAuthorship W2801400980A5072437547 @default.
• W2801400980 hasAuthorship W2801400980A5091234288 @default.
• W2801400980 hasBestOaLocation W28014009801 @default.
• W2801400980 hasConcept C148762608 @default.
• W2801400980 hasConcept C159985019 @default.
• W2801400980 hasConcept C169760540 @default.
• W2801400980 hasConcept C170493617 @default.
• W2801400980 hasConcept C174884520 @default.
• W2801400980 hasConcept C192562407 @default.
• W2801400980 hasConcept C25274449 @default.
• W2801400980 hasConcept C2776464000 @default.
• W2801400980 hasConcept C2778888523 @default.

• next