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• W2801412095 abstract "Background: The mechanisms leading from traumatic stress to social, emotional and cognitive impairment and the development of mental illnesses are still undetermined and consequently there remains a critical need to develop therapies for preventing the adverse consequences of traumatic stress. Research indicates nicotinic acetylcholine receptors containing α4 subunits (α4*nAChRs) are both impacted by stress and capable of modulating the stress response. In this study, we investigated whether varenicline, a partial α4β2*nAChR agonist which reduces nicotine, alcohol and sucrose consumption, can reduce stress, a driving factor in substance use disorders. We also examined the effect of stress on nucleus accumbens (NAc) α4*nAChR expression. Methods: Transgenic mice with fluorescent tags attached to α4*nAChRs were administered varenicline and/or yohimbine (a pharmacological stressor) and plasma corticosterone and NAc α4*nAChR expression were measured. A separated group of mice were exposed to maternal separation (MS) during post-natal day (P) 2–14, then restraint stressed (30 min) at six weeks of age. Body weight, anxiety-like behaviours (elevated plus maze), plasma corticosterone and NAc α4*nAChR levels were measured. Results: Varenicline attenuated yohimbine-induced plasma corticosterone increases with no effect on NAc α4*nAChR expression. MS reduced unrestrained plasma corticosterone levels in both sexes. In females, MS increased body weight and NAc α4*nAChR expression, whereas, in males, MS and restraint caused a greater change in anxiety-like behaviours and plasma corticosterone levels. Restraint altered NAc α4*nAChR expression in both male and female MS mice. Conclusions: The effects of stress on NAc α4*nAChR are sex-dependent. While varenicline attenuated acute stress-induced rises in corticosterone levels, future studies are required to determine whether varenicline is effective for relieving the effects of stress." @default.
• W2801412095 created "2018-05-17" @default.
• W2801412095 creator A5021561294 @default.
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• W2801412095 date "2018-04-19" @default.
• W2801412095 modified "2023-09-25" @default.
• W2801412095 title "Sex Specific Alterations in α4*Nicotinic Receptor Expression in the Nucleus Accumbens" @default.
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• W2801412095 doi "https://doi.org/10.3390/brainsci8040070" @default.
• W2801412095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5924406" @default.
• W2801412095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29671814" @default.
• W2801412095 hasPublicationYear "2018" @default.
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