Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801425548> ?p ?o ?g. }
- W2801425548 endingPage "263" @default.
- W2801425548 startingPage "257" @default.
- W2801425548 abstract "The impact of antithrombin replacement during extracorporeal membrane oxygenation (ECMO) in adults remains unclear. This work comprises a survey, showing that antithrombin is routinely supplemented in many Italian ECMO-Centers, and a retrospective analysis on 66 adults treated with veno-venous ECMO and unfractionated heparin at our Institution. Twenty-four to 72 h after the beginning of ECMO, antithrombin activity was ≤70% in 47/66 subjects and activated partial thromboplastin time (aPTT) ratio was <1.5 in 20/66 subjects. Activated partial thromboplastin time ratio <1.5 was associated not with lower antithrombin activity (61 ± 17 vs. 63 ± 22%; p = 0.983) but with higher circulating level of C-reactive protein (23 ± 8 vs. 11 ± 9 mg/dl; p < 0.001). In 34 subjects who received antithrombin concentrate, antithrombin activity increased (from 54 ± 9 to 84 ± 13%; p < 0.001); the proportion of subjects with aPTT ratio ≥1.5 increased (from 21/34 [62%] to 31/34 [91%]; p = 0.004); heparin dosage remained constant (from 19 ± 7 to 19 ± 6 IU/kg/h; p = 0.543); and C-reactive protein decreased (from 17 ± 10 to 13 ± 9 mg/dl; p = 0.013). Among those with aPTT ratio <1.5, aPTT ratio remained <1.5 in 3 out of 13 subjects. Antithrombin is frequently supplemented during veno-venous ECMO although low antithrombin activity does not constantly impede, and antithrombin replacement does not constantly ensure, reaching the target aPTT ratio. Inflammation possibly affects the individual response to heparin." @default.
- W2801425548 created "2018-05-17" @default.
- W2801425548 creator A5002816386 @default.
- W2801425548 creator A5006917212 @default.
- W2801425548 creator A5012262301 @default.
- W2801425548 creator A5013198517 @default.
- W2801425548 creator A5014018414 @default.
- W2801425548 creator A5024573108 @default.
- W2801425548 creator A5053473631 @default.
- W2801425548 creator A5084652949 @default.
- W2801425548 date "2019-03-01" @default.
- W2801425548 modified "2023-10-01" @default.
- W2801425548 title "Antithrombin During Extracorporeal Membrane Oxygenation in Adults: National Survey and Retrospective Analysis" @default.
- W2801425548 cites W1487079201 @default.
- W2801425548 cites W1520348292 @default.
- W2801425548 cites W1539267720 @default.
- W2801425548 cites W1579223497 @default.
- W2801425548 cites W1921148719 @default.
- W2801425548 cites W1968334582 @default.
- W2801425548 cites W1979838917 @default.
- W2801425548 cites W1984246714 @default.
- W2801425548 cites W1987433975 @default.
- W2801425548 cites W2003915795 @default.
- W2801425548 cites W2005798908 @default.
- W2801425548 cites W2014129146 @default.
- W2801425548 cites W2024030753 @default.
- W2801425548 cites W2034361397 @default.
- W2801425548 cites W2037463783 @default.
- W2801425548 cites W2039989814 @default.
- W2801425548 cites W2073325230 @default.
- W2801425548 cites W2074475417 @default.
- W2801425548 cites W2079260184 @default.
- W2801425548 cites W2080167098 @default.
- W2801425548 cites W2082416969 @default.
- W2801425548 cites W2085873519 @default.
- W2801425548 cites W2132679528 @default.
- W2801425548 cites W2139937737 @default.
- W2801425548 cites W2158969879 @default.
- W2801425548 cites W2238441516 @default.
- W2801425548 cites W2313712290 @default.
- W2801425548 cites W2337811204 @default.
- W2801425548 cites W2411821200 @default.
- W2801425548 cites W242055564 @default.
- W2801425548 cites W2443723210 @default.
- W2801425548 cites W2521995441 @default.
- W2801425548 cites W2563391002 @default.
- W2801425548 cites W2590123800 @default.
- W2801425548 cites W2603486193 @default.
- W2801425548 cites W2610316746 @default.
- W2801425548 doi "https://doi.org/10.1097/mat.0000000000000806" @default.
- W2801425548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29746315" @default.
- W2801425548 hasPublicationYear "2019" @default.
- W2801425548 type Work @default.
- W2801425548 sameAs 2801425548 @default.
- W2801425548 citedByCount "19" @default.
- W2801425548 countsByYear W28014255482019 @default.
- W2801425548 countsByYear W28014255482020 @default.
- W2801425548 countsByYear W28014255482021 @default.
- W2801425548 countsByYear W28014255482022 @default.
- W2801425548 countsByYear W28014255482023 @default.
- W2801425548 crossrefType "journal-article" @default.
- W2801425548 hasAuthorship W2801425548A5002816386 @default.
- W2801425548 hasAuthorship W2801425548A5006917212 @default.
- W2801425548 hasAuthorship W2801425548A5012262301 @default.
- W2801425548 hasAuthorship W2801425548A5013198517 @default.
- W2801425548 hasAuthorship W2801425548A5014018414 @default.
- W2801425548 hasAuthorship W2801425548A5024573108 @default.
- W2801425548 hasAuthorship W2801425548A5053473631 @default.
- W2801425548 hasAuthorship W2801425548A5084652949 @default.
- W2801425548 hasConcept C126322002 @default.
- W2801425548 hasConcept C141071460 @default.
- W2801425548 hasConcept C167135981 @default.
- W2801425548 hasConcept C2776858399 @default.
- W2801425548 hasConcept C2777557582 @default.
- W2801425548 hasConcept C2778261982 @default.
- W2801425548 hasConcept C2779026020 @default.
- W2801425548 hasConcept C42219234 @default.
- W2801425548 hasConcept C71924100 @default.
- W2801425548 hasConcept C89560881 @default.
- W2801425548 hasConceptScore W2801425548C126322002 @default.
- W2801425548 hasConceptScore W2801425548C141071460 @default.
- W2801425548 hasConceptScore W2801425548C167135981 @default.
- W2801425548 hasConceptScore W2801425548C2776858399 @default.
- W2801425548 hasConceptScore W2801425548C2777557582 @default.
- W2801425548 hasConceptScore W2801425548C2778261982 @default.
- W2801425548 hasConceptScore W2801425548C2779026020 @default.
- W2801425548 hasConceptScore W2801425548C42219234 @default.
- W2801425548 hasConceptScore W2801425548C71924100 @default.
- W2801425548 hasConceptScore W2801425548C89560881 @default.
- W2801425548 hasIssue "3" @default.
- W2801425548 hasLocation W28014255481 @default.
- W2801425548 hasLocation W28014255482 @default.
- W2801425548 hasOpenAccess W2801425548 @default.
- W2801425548 hasPrimaryLocation W28014255481 @default.
- W2801425548 hasRelatedWork W1721577355 @default.
- W2801425548 hasRelatedWork W1979977195 @default.
- W2801425548 hasRelatedWork W2062512292 @default.
- W2801425548 hasRelatedWork W2065555182 @default.