FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801440855> ?p ?o ?g. }

• W2801440855 endingPage "C246" @default.
• W2801440855 startingPage "C236" @default.
• W2801440855 abstract "Optimal vision requires an ocular surface with a stable tear film whose many critical tasks include providing >70% of the eye’s refractive power. However, for millions, tear film instability produces uncomfortable sight-impairing dry eye. Despite the multitude of etiologies for dry eye, a universal hallmark is hyperosmolarity of the tear film. Presently, knowledge of how the ocular surface responds to hyperosmolarity remains incomplete with little understood about the role of ion channels. This bioelectric analysis focused on conjunctival goblet cells whose release of tear-stabilizing mucin is a key adaptive response to dry eye. In freshly excised rat conjunctiva, perforated-patch recordings demonstrated that a ≥10% rise in osmolarity triggers goblet cells to rapidly generate a ~15-mV hyperpolarization due to the oxidant-dependent activation of ATP-sensitive K + (K ATP ) channels. High-resolution membrane capacitance measurements used to monitor exocytosis revealed that this hyperpolarization results in an approximately fourfold boost in exocytotic activity evoked by cholinergic input, which in vivo occurs via a neural reflex and depends chiefly on calcium influxing down its electro-gradient. We discovered that this adaptive response is transient. During 30–80 min of hyperosmolarity, development of a depolarizing nonspecific cation conductance fully counterbalances the K ATP -driven hyperpolarization and thereby eliminates the exocytotic boost. We conclude that hyperosmotic-induced hyperpolarization is a previously unappreciated mechanism by which goblet cells respond to transient ocular dryness. Loss of this voltage increase during long-term dryness/hyperosmolarity may account for the clinical conundrum that goblet cells in chronically dry eyes can remain filled with mucin even though the tear film is hyperosmotic and mucin-deficient." @default.
• W2801440855 created "2018-05-17" @default.
• W2801440855 creator A5055088567 @default.
• W2801440855 date "2018-08-01" @default.
• W2801440855 modified "2023-10-17" @default.
• W2801440855 title "Role of ion channels in the functional response of conjunctival goblet cells to dry eye" @default.
• W2801440855 cites W1017603874 @default.
• W2801440855 cites W118400788 @default.
• W2801440855 cites W1501356449 @default.
• W2801440855 cites W1571886384 @default.
• W2801440855 cites W1908394 @default.
• W2801440855 cites W1968788883 @default.
• W2801440855 cites W1974879138 @default.
• W2801440855 cites W1975103296 @default.
• W2801440855 cites W1984483336 @default.
• W2801440855 cites W1987117141 @default.
• W2801440855 cites W1994417972 @default.
• W2801440855 cites W2004698731 @default.
• W2801440855 cites W2014242340 @default.
• W2801440855 cites W2022968719 @default.
• W2801440855 cites W2026447406 @default.
• W2801440855 cites W2026909226 @default.
• W2801440855 cites W2034791541 @default.
• W2801440855 cites W2058305185 @default.
• W2801440855 cites W2079295452 @default.
• W2801440855 cites W2080938154 @default.
• W2801440855 cites W2088174753 @default.
• W2801440855 cites W2094488436 @default.
• W2801440855 cites W2096399483 @default.
• W2801440855 cites W2114864480 @default.
• W2801440855 cites W2116657787 @default.
• W2801440855 cites W2120853484 @default.
• W2801440855 cites W2121158588 @default.
• W2801440855 cites W2125588561 @default.
• W2801440855 cites W2140079683 @default.
• W2801440855 cites W2143112599 @default.
• W2801440855 cites W2148222883 @default.
• W2801440855 cites W2153189178 @default.
• W2801440855 cites W2158137565 @default.
• W2801440855 cites W2167683291 @default.
• W2801440855 cites W2188484637 @default.
• W2801440855 cites W2202085130 @default.
• W2801440855 cites W2284575233 @default.
• W2801440855 cites W2339501161 @default.
• W2801440855 cites W2507253368 @default.
• W2801440855 cites W270891856 @default.
• W2801440855 cites W2737439597 @default.
• W2801440855 cites W2737642784 @default.
• W2801440855 cites W2765242879 @default.
• W2801440855 cites W30473474 @default.
• W2801440855 cites W35323487 @default.
• W2801440855 cites W85387919 @default.
• W2801440855 doi "https://doi.org/10.1152/ajpcell.00077.2018" @default.
• W2801440855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6139504" @default.
• W2801440855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29669221" @default.
• W2801440855 hasPublicationYear "2018" @default.
• W2801440855 type Work @default.
• W2801440855 sameAs 2801440855 @default.
• W2801440855 citedByCount "11" @default.
• W2801440855 countsByYear W28014408552019 @default.
• W2801440855 countsByYear W28014408552020 @default.
• W2801440855 countsByYear W28014408552021 @default.
• W2801440855 countsByYear W28014408552022 @default.
• W2801440855 countsByYear W28014408552023 @default.
• W2801440855 crossrefType "journal-article" @default.
• W2801440855 hasAuthorship W2801440855A5055088567 @default.
• W2801440855 hasBestOaLocation W28014408551 @default.
• W2801440855 hasConcept C12554922 @default.
• W2801440855 hasConcept C129900496 @default.
• W2801440855 hasConcept C131453863 @default.
• W2801440855 hasConcept C178790620 @default.
• W2801440855 hasConcept C185592680 @default.
• W2801440855 hasConcept C4141045 @default.
• W2801440855 hasConcept C55493867 @default.
• W2801440855 hasConcept C66974803 @default.
• W2801440855 hasConcept C86803240 @default.
• W2801440855 hasConcept C95444343 @default.
• W2801440855 hasConceptScore W2801440855C12554922 @default.
• W2801440855 hasConceptScore W2801440855C129900496 @default.
• W2801440855 hasConceptScore W2801440855C131453863 @default.
• W2801440855 hasConceptScore W2801440855C178790620 @default.
• W2801440855 hasConceptScore W2801440855C185592680 @default.
• W2801440855 hasConceptScore W2801440855C4141045 @default.
• W2801440855 hasConceptScore W2801440855C55493867 @default.
• W2801440855 hasConceptScore W2801440855C66974803 @default.
• W2801440855 hasConceptScore W2801440855C86803240 @default.
• W2801440855 hasConceptScore W2801440855C95444343 @default.
• W2801440855 hasFunder F4320306811 @default.
• W2801440855 hasFunder F4320332161 @default.
• W2801440855 hasIssue "2" @default.
• W2801440855 hasLocation W28014408551 @default.
• W2801440855 hasLocation W28014408552 @default.
• W2801440855 hasLocation W28014408553 @default.
• W2801440855 hasLocation W28014408554 @default.
• W2801440855 hasOpenAccess W2801440855 @default.
• W2801440855 hasPrimaryLocation W28014408551 @default.
• W2801440855 hasRelatedWork W1973402474 @default.
• W2801440855 hasRelatedWork W1974458161 @default.

• next