FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801453085> ?p ?o ?g. }

• W2801453085 endingPage "1402" @default.
• W2801453085 startingPage "1390" @default.
• W2801453085 abstract "Natural killer cells are the first lymphocyte population to reconstitute early after non-myeloablative and T cell-replete haploidentical hematopoietic stem cell transplantation with post-transplant infusion of cyclophosphamide. The study herein characterizes the transient and predominant expansion starting from the second week following haploidentical hematopoietic stem cell transplantation of a donor-derived unconventional subset of NKp46neg-low/CD56dim/CD16neg natural killer cells expressing remarkably high levels of CD94/NKG2A. Both transcription and phenotypic profiles indicated that unconventional NKp46neg-low/CD56dim/CD16neg cells are a distinct natural killer cell subpopulation with features of late stage differentiation, yet retaining proliferative capability and functional plasticity to generate conventional NKp46pos/CD56bright/CD16neg-low cells in response to interleukin-15 plus interleukin-18. While present at low frequency in healthy donors, unconventional NKp46neg-low/CD56dim/CD16neg cells are greatly expanded in the seven weeks following haploidentical hematopoietic stem cell transplantation, and express high levels of the activating receptors NKG2D and NKp30 as well as of the lytic granules Granzyme-B and Perforin. Nonetheless, NKp46neg-low/CD56dim/CD16neg cells displayed a markedly defective cytotoxicity that could be reversed by blocking the inhibitory receptor CD94/NKG2A. These data open new and important perspectives to better understand the ontogenesis/homeostasis of human natural killer cells and to develop a novel immune-therapeutic approach that targets the inhibitory NKG2A check-point, thus unleashing natural killer cell alloreactivity early after haploidentical hematopoietic stem cell transplantation." @default.
• W2801453085 created "2018-05-17" @default.
• W2801453085 creator A5007404078 @default.
• W2801453085 creator A5013760932 @default.
• W2801453085 creator A5019562681 @default.
• W2801453085 creator A5021041745 @default.
• W2801453085 creator A5021060422 @default.
• W2801453085 creator A5023596964 @default.
• W2801453085 creator A5040305422 @default.
• W2801453085 creator A5045159459 @default.
• W2801453085 creator A5048023278 @default.
• W2801453085 creator A5056155567 @default.
• W2801453085 creator A5061015160 @default.
• W2801453085 creator A5062054067 @default.
• W2801453085 creator A5073353725 @default.
• W2801453085 creator A5077942090 @default.
• W2801453085 creator A5078056183 @default.
• W2801453085 creator A5080298171 @default.
• W2801453085 creator A5082045927 @default.
• W2801453085 creator A5082718236 @default.
• W2801453085 creator A5084668012 @default.
• W2801453085 creator A5090939942 @default.
• W2801453085 date "2018-04-26" @default.
• W2801453085 modified "2023-10-16" @default.
• W2801453085 title "The early expansion of anergic NKG2A^pos/CD56^dim/CD16^neg natural killer represents a therapeutic target in haploidentical hematopoietic stem cell transplantation" @default.
• W2801453085 cites W1579469646 @default.
• W2801453085 cites W1607713199 @default.
• W2801453085 cites W1741012896 @default.
• W2801453085 cites W1964548129 @default.
• W2801453085 cites W1965684555 @default.
• W2801453085 cites W1966128754 @default.
• W2801453085 cites W1967920980 @default.
• W2801453085 cites W1969814796 @default.
• W2801453085 cites W1975053754 @default.
• W2801453085 cites W1981542309 @default.
• W2801453085 cites W1982433646 @default.
• W2801453085 cites W1982729887 @default.
• W2801453085 cites W1989765997 @default.
• W2801453085 cites W1991640519 @default.
• W2801453085 cites W2003339708 @default.
• W2801453085 cites W2005242977 @default.
• W2801453085 cites W2005765588 @default.
• W2801453085 cites W2014208459 @default.
• W2801453085 cites W2023319194 @default.
• W2801453085 cites W2039334806 @default.
• W2801453085 cites W2042877348 @default.
• W2801453085 cites W2047031579 @default.
• W2801453085 cites W2054335599 @default.
• W2801453085 cites W2077254590 @default.
• W2801453085 cites W2078228665 @default.
• W2801453085 cites W2079023050 @default.
• W2801453085 cites W2092705670 @default.
• W2801453085 cites W2112028601 @default.
• W2801453085 cites W2130649175 @default.
• W2801453085 cites W2138362010 @default.
• W2801453085 cites W2144967266 @default.
• W2801453085 cites W2146313292 @default.
• W2801453085 cites W2146685162 @default.
• W2801453085 cites W2147068163 @default.
• W2801453085 cites W2171709048 @default.
• W2801453085 cites W2201929875 @default.
• W2801453085 cites W2512001250 @default.
• W2801453085 cites W2515527586 @default.
• W2801453085 cites W2584431542 @default.
• W2801453085 cites W2601892854 @default.
• W2801453085 cites W2607529759 @default.
• W2801453085 cites W2742185070 @default.
• W2801453085 cites W2763346562 @default.
• W2801453085 cites W2763653175 @default.
• W2801453085 doi "https://doi.org/10.3324/haematol.2017.186619" @default.
• W2801453085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6068034" @default.
• W2801453085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29700172" @default.
• W2801453085 hasPublicationYear "2018" @default.
• W2801453085 type Work @default.
• W2801453085 sameAs 2801453085 @default.
• W2801453085 citedByCount "52" @default.
• W2801453085 countsByYear W28014530852018 @default.
• W2801453085 countsByYear W28014530852019 @default.
• W2801453085 countsByYear W28014530852020 @default.
• W2801453085 countsByYear W28014530852021 @default.
• W2801453085 countsByYear W28014530852022 @default.
• W2801453085 countsByYear W28014530852023 @default.
• W2801453085 crossrefType "journal-article" @default.
• W2801453085 hasAuthorship W2801453085A5007404078 @default.
• W2801453085 hasAuthorship W2801453085A5013760932 @default.
• W2801453085 hasAuthorship W2801453085A5019562681 @default.
• W2801453085 hasAuthorship W2801453085A5021041745 @default.
• W2801453085 hasAuthorship W2801453085A5021060422 @default.
• W2801453085 hasAuthorship W2801453085A5023596964 @default.
• W2801453085 hasAuthorship W2801453085A5040305422 @default.
• W2801453085 hasAuthorship W2801453085A5045159459 @default.
• W2801453085 hasAuthorship W2801453085A5048023278 @default.
• W2801453085 hasAuthorship W2801453085A5056155567 @default.
• W2801453085 hasAuthorship W2801453085A5061015160 @default.
• W2801453085 hasAuthorship W2801453085A5062054067 @default.
• W2801453085 hasAuthorship W2801453085A5073353725 @default.
• W2801453085 hasAuthorship W2801453085A5077942090 @default.
• W2801453085 hasAuthorship W2801453085A5078056183 @default.

• next