FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801453912> ?p ?o ?g. }

• W2801453912 endingPage "1692" @default.
• W2801453912 startingPage "1686" @default.
• W2801453912 abstract "Diacylglycerol acyltransferase (DGAT) is expressed abundantly in intestine, liver, and adipose tissues. DGAT1 is the crucial and rate-limiting enzyme that mediates the final step in triacylglycerol (TAG) resynthesis during dietary fat absorption. However, too much triacylglycerol (TAG) reserve will lead to genetic obesity (Hubert et al., 2000). DGAT1 knockout mice could survive and displayed a reduction in the postprandial rise of plasma TG, and increased sensitivity of insulin and leptin. Here we report the discovery and characterization of a novel selective DGAT1 inhibitor 29 to potentially treat obesity. Compound 29 showed lipid lowering effect in mouse lipid tolerance test (LTT) and also reduced body weight in DIO mice without observable liver damage." @default.
• W2801453912 created "2018-05-17" @default.
• W2801453912 creator A5001215093 @default.
• W2801453912 creator A5005177023 @default.
• W2801453912 creator A5015379959 @default.
• W2801453912 creator A5016317525 @default.
• W2801453912 creator A5017041562 @default.
• W2801453912 creator A5020746135 @default.
• W2801453912 creator A5027018015 @default.
• W2801453912 creator A5041512369 @default.
• W2801453912 creator A5052883326 @default.
• W2801453912 creator A5053674695 @default.
• W2801453912 creator A5070861132 @default.
• W2801453912 creator A5074706575 @default.
• W2801453912 creator A5091437311 @default.
• W2801453912 date "2018-06-01" @default.
• W2801453912 modified "2023-09-23" @default.
• W2801453912 title "Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model" @default.
• W2801453912 cites W1981293724 @default.
• W2801453912 cites W1993583808 @default.
• W2801453912 cites W2010363699 @default.
• W2801453912 cites W2016001739 @default.
• W2801453912 cites W2043350546 @default.
• W2801453912 cites W2047101066 @default.
• W2801453912 cites W2048328206 @default.
• W2801453912 cites W2070098406 @default.
• W2801453912 cites W2075720989 @default.
• W2801453912 cites W2124311778 @default.
• W2801453912 cites W2142461696 @default.
• W2801453912 cites W2409438593 @default.
• W2801453912 cites W2612054874 @default.
• W2801453912 cites W2950770390 @default.
• W2801453912 doi "https://doi.org/10.1016/j.bmcl.2018.04.051" @default.
• W2801453912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29699923" @default.
• W2801453912 hasPublicationYear "2018" @default.
• W2801453912 type Work @default.
• W2801453912 sameAs 2801453912 @default.
• W2801453912 citedByCount "6" @default.
• W2801453912 countsByYear W28014539122018 @default.
• W2801453912 countsByYear W28014539122019 @default.
• W2801453912 countsByYear W28014539122020 @default.
• W2801453912 countsByYear W28014539122022 @default.
• W2801453912 countsByYear W28014539122023 @default.
• W2801453912 crossrefType "journal-article" @default.
• W2801453912 hasAuthorship W2801453912A5001215093 @default.
• W2801453912 hasAuthorship W2801453912A5005177023 @default.
• W2801453912 hasAuthorship W2801453912A5015379959 @default.
• W2801453912 hasAuthorship W2801453912A5016317525 @default.
• W2801453912 hasAuthorship W2801453912A5017041562 @default.
• W2801453912 hasAuthorship W2801453912A5020746135 @default.
• W2801453912 hasAuthorship W2801453912A5027018015 @default.
• W2801453912 hasAuthorship W2801453912A5041512369 @default.
• W2801453912 hasAuthorship W2801453912A5052883326 @default.
• W2801453912 hasAuthorship W2801453912A5053674695 @default.
• W2801453912 hasAuthorship W2801453912A5070861132 @default.
• W2801453912 hasAuthorship W2801453912A5074706575 @default.
• W2801453912 hasAuthorship W2801453912A5091437311 @default.
• W2801453912 hasConcept C126322002 @default.
• W2801453912 hasConcept C134018914 @default.
• W2801453912 hasConcept C171089720 @default.
• W2801453912 hasConcept C181199279 @default.
• W2801453912 hasConcept C181389837 @default.
• W2801453912 hasConcept C185592680 @default.
• W2801453912 hasConcept C195794163 @default.
• W2801453912 hasConcept C2778199505 @default.
• W2801453912 hasConcept C2779306644 @default.
• W2801453912 hasConcept C2779685201 @default.
• W2801453912 hasConcept C36020004 @default.
• W2801453912 hasConcept C4733338 @default.
• W2801453912 hasConcept C55493867 @default.
• W2801453912 hasConcept C71924100 @default.
• W2801453912 hasConcept C86803240 @default.
• W2801453912 hasConcept C98274493 @default.
• W2801453912 hasConceptScore W2801453912C126322002 @default.
• W2801453912 hasConceptScore W2801453912C134018914 @default.
• W2801453912 hasConceptScore W2801453912C171089720 @default.
• W2801453912 hasConceptScore W2801453912C181199279 @default.
• W2801453912 hasConceptScore W2801453912C181389837 @default.
• W2801453912 hasConceptScore W2801453912C185592680 @default.
• W2801453912 hasConceptScore W2801453912C195794163 @default.
• W2801453912 hasConceptScore W2801453912C2778199505 @default.
• W2801453912 hasConceptScore W2801453912C2779306644 @default.
• W2801453912 hasConceptScore W2801453912C2779685201 @default.
• W2801453912 hasConceptScore W2801453912C36020004 @default.
• W2801453912 hasConceptScore W2801453912C4733338 @default.
• W2801453912 hasConceptScore W2801453912C55493867 @default.
• W2801453912 hasConceptScore W2801453912C71924100 @default.
• W2801453912 hasConceptScore W2801453912C86803240 @default.
• W2801453912 hasConceptScore W2801453912C98274493 @default.
• W2801453912 hasIssue "10" @default.
• W2801453912 hasLocation W28014539121 @default.
• W2801453912 hasLocation W28014539122 @default.
• W2801453912 hasOpenAccess W2801453912 @default.
• W2801453912 hasPrimaryLocation W28014539121 @default.
• W2801453912 hasRelatedWork W1998945191 @default.
• W2801453912 hasRelatedWork W2012525570 @default.
• W2801453912 hasRelatedWork W2038812526 @default.
• W2801453912 hasRelatedWork W2040437316 @default.

• next