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- W2801464162 abstract "Despite serious health effects, volatile industrial products containing toluene are deliberately inhaled for their psychoactive actions, mainly among adolescents and young adults. Chronic toluene inhalation induces multiple alterations at the cellular and behavioral level; however, modifications of neuronal networks associated with the reward system after repeated toluene exposure are not thoroughly characterized. Here we used whole-cell recordings to determine the effects of repeated exposure to toluene (1000, 4000 or 8000 ppm for 30 min, twice a day, for ten days) on the neurophysiological properties of prelimbic layer 5 pyramidal neurons of the medial prefrontal cortex (mPFC) in adolescent male Wistar rats. Neurons from animals repeatedly exposed to toluene showed a concentration-dependent increase in action potential firing discharge. This increase was related to a reduction of the small-conductance calcium-activated potassium current (after-hyperpolarization current, IAHP) that controls the firing frequency of neurons. Likewise, toluene altered the kinetics of the action potential. The hyperexcitability seen in toluene-exposed animals was also associated with an increase in the glutamatergic spontaneous synaptic activity converging on mPFC neurons. In summary, repeated toluene exposure enhances the excitability of prelimbic layer 5 pyramidal neurons of the mPFC in adolescent rats." @default.
- W2801464162 created "2018-05-17" @default.
- W2801464162 creator A5000714262 @default.
- W2801464162 creator A5043865354 @default.
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- W2801464162 date "2018-07-01" @default.
- W2801464162 modified "2023-10-15" @default.
- W2801464162 title "Repeated toluene exposure increases the excitability of layer 5 pyramidal neurons in the prefrontal cortex of adolescent rats" @default.
- W2801464162 cites W1099116183 @default.
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- W2801464162 cites W1978121152 @default.
- W2801464162 cites W1987853889 @default.
- W2801464162 cites W1990926259 @default.
- W2801464162 cites W1995007954 @default.
- W2801464162 cites W1995451435 @default.
- W2801464162 cites W1997974439 @default.
- W2801464162 cites W1998734009 @default.
- W2801464162 cites W1999473180 @default.
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- W2801464162 cites W2025525051 @default.
- W2801464162 cites W2032905722 @default.
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- W2801464162 doi "https://doi.org/10.1016/j.ntt.2018.04.006" @default.
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