Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801471176> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2801471176 abstract "Trichoderma brevicompactum and T. arundinaceum both can synthesize trichodermin with strong antifungal activity and high biotechnological value. The two Trichoderma species have a tri cluster, which includes seven genes (tri14, tri12, tri11, tri10, tri3, tri4, and tri6) that encode transport and regulatory enzymes required for the biosynthesis of trichodermin. Here, we isolated T. brevicompactum 0248 transformants with disrupted tri11, tri4, or tri3 gene. We also described the effect of tri11, tri3, or tri4 deletion on the expression of other genes in the tri cluster. Targeted Δtri3 knockout mutant exhibited a sharp decline in the production of trichodermin, and trichodermol, which is a substrate for trichodermin production, accumulated. Thus, the results demonstrated that tri3 was responsible for the biosynthesis of trichodermin, and the tri3 gene-encoded enzyme catalyzed the acetylation reaction of the hydroxy group at C-4 of the trichodermin skeleton. In addition, tri4 and tri11 deletion mutants were generated to evaluate the roles of tri4 and tri11 in trichodermin biosynthesis, respectively. Deletion mutant strain Δtri4 or Δtri11 did not produce trichodermin in T. brevicompactum, indicating that tri4 and tri11 are essential for trichodermin biosynthesis. This is the first to report the function of tri3, tri4 and tri11 in T. brevicompactum, although the role of tri4 and tri11 has already been described for T. arundinaceum by Cardoza et al. (Appl Environ Microbiol 77:4867–4877, 2011)." @default.
- W2801471176 created "2018-05-17" @default.
- W2801471176 creator A5011320222 @default.
- W2801471176 creator A5017453032 @default.
- W2801471176 creator A5026909971 @default.
- W2801471176 creator A5037478181 @default.
- W2801471176 creator A5061091254 @default.
- W2801471176 creator A5083709577 @default.
- W2801471176 creator A5088076962 @default.
- W2801471176 date "2018-04-17" @default.
- W2801471176 modified "2023-10-14" @default.
- W2801471176 title "Tri11, tri3, and tri4 genes are required for trichodermin biosynthesis of Trichoderma brevicompactum" @default.
- W2801471176 cites W1968422424 @default.
- W2801471176 cites W1970231827 @default.
- W2801471176 cites W1981727849 @default.
- W2801471176 cites W1998719612 @default.
- W2801471176 cites W2002880495 @default.
- W2801471176 cites W2007101778 @default.
- W2801471176 cites W2015851647 @default.
- W2801471176 cites W2025620181 @default.
- W2801471176 cites W2032209192 @default.
- W2801471176 cites W2043416269 @default.
- W2801471176 cites W2049900329 @default.
- W2801471176 cites W2053552210 @default.
- W2801471176 cites W2059490168 @default.
- W2801471176 cites W2067699530 @default.
- W2801471176 cites W2078457554 @default.
- W2801471176 cites W2083759325 @default.
- W2801471176 cites W2089400875 @default.
- W2801471176 cites W2097189192 @default.
- W2801471176 cites W2098084671 @default.
- W2801471176 cites W2105158067 @default.
- W2801471176 cites W2163402775 @default.
- W2801471176 cites W2164895981 @default.
- W2801471176 cites W2167367711 @default.
- W2801471176 cites W2170049887 @default.
- W2801471176 cites W2626807114 @default.
- W2801471176 doi "https://doi.org/10.1186/s13568-018-0585-4" @default.
- W2801471176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5904096" @default.
- W2801471176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29667033" @default.
- W2801471176 hasPublicationYear "2018" @default.
- W2801471176 type Work @default.
- W2801471176 sameAs 2801471176 @default.
- W2801471176 citedByCount "7" @default.
- W2801471176 countsByYear W28014711762020 @default.
- W2801471176 countsByYear W28014711762021 @default.
- W2801471176 countsByYear W28014711762022 @default.
- W2801471176 countsByYear W28014711762023 @default.
- W2801471176 crossrefType "journal-article" @default.
- W2801471176 hasAuthorship W2801471176A5011320222 @default.
- W2801471176 hasAuthorship W2801471176A5017453032 @default.
- W2801471176 hasAuthorship W2801471176A5026909971 @default.
- W2801471176 hasAuthorship W2801471176A5037478181 @default.
- W2801471176 hasAuthorship W2801471176A5061091254 @default.
- W2801471176 hasAuthorship W2801471176A5083709577 @default.
- W2801471176 hasAuthorship W2801471176A5088076962 @default.
- W2801471176 hasBestOaLocation W28014711761 @default.
- W2801471176 hasConcept C104317684 @default.
- W2801471176 hasConcept C143065580 @default.
- W2801471176 hasConcept C2780214302 @default.
- W2801471176 hasConcept C36857842 @default.
- W2801471176 hasConcept C54355233 @default.
- W2801471176 hasConcept C553450214 @default.
- W2801471176 hasConcept C59822182 @default.
- W2801471176 hasConcept C86803240 @default.
- W2801471176 hasConcept C89423630 @default.
- W2801471176 hasConceptScore W2801471176C104317684 @default.
- W2801471176 hasConceptScore W2801471176C143065580 @default.
- W2801471176 hasConceptScore W2801471176C2780214302 @default.
- W2801471176 hasConceptScore W2801471176C36857842 @default.
- W2801471176 hasConceptScore W2801471176C54355233 @default.
- W2801471176 hasConceptScore W2801471176C553450214 @default.
- W2801471176 hasConceptScore W2801471176C59822182 @default.
- W2801471176 hasConceptScore W2801471176C86803240 @default.
- W2801471176 hasConceptScore W2801471176C89423630 @default.
- W2801471176 hasIssue "1" @default.
- W2801471176 hasLocation W28014711761 @default.
- W2801471176 hasLocation W28014711762 @default.
- W2801471176 hasLocation W28014711763 @default.
- W2801471176 hasLocation W28014711764 @default.
- W2801471176 hasLocation W28014711765 @default.
- W2801471176 hasOpenAccess W2801471176 @default.
- W2801471176 hasPrimaryLocation W28014711761 @default.
- W2801471176 hasRelatedWork W1973535534 @default.
- W2801471176 hasRelatedWork W2008669354 @default.
- W2801471176 hasRelatedWork W2023374624 @default.
- W2801471176 hasRelatedWork W2060445483 @default.
- W2801471176 hasRelatedWork W2074599985 @default.
- W2801471176 hasRelatedWork W2086282504 @default.
- W2801471176 hasRelatedWork W2112809089 @default.
- W2801471176 hasRelatedWork W2117110650 @default.
- W2801471176 hasRelatedWork W2122540340 @default.
- W2801471176 hasRelatedWork W2999033088 @default.
- W2801471176 hasVolume "8" @default.
- W2801471176 isParatext "false" @default.
- W2801471176 isRetracted "false" @default.
- W2801471176 magId "2801471176" @default.
- W2801471176 workType "article" @default.