Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801476600> ?p ?o ?g. }
- W2801476600 endingPage "74" @default.
- W2801476600 startingPage "74" @default.
- W2801476600 abstract "Our review suggests that most autism spectrum disorder (ASD) risk factors are connected, either directly or indirectly, to immunoexcitotoxicity. Chronic brain inflammation is known to enhance the sensitivity of glutamate receptors and interfere with glutamate removal from the extraneuronal space, where it can trigger excitotoxicity over a prolonged period. Neuroscience studies have clearly shown that sequential systemic immune stimulation can activate the brain's immune system, microglia, and astrocytes, and that with initial immune stimulation, there occurs CNS microglial priming. Children are exposed to such sequential immune stimulation via a growing number of environmental excitotoxins, vaccines, and persistent viral infections. We demonstrate that fluoride and aluminum (Al3+) can exacerbate the pathological problems by worsening excitotoxicity and inflammation. While Al3+ appears among the key suspicious factors of ASD, fluoride is rarely recognized as a causative culprit. A long-term burden of these ubiquitous toxins has several health effects with a striking resemblance to the symptoms of ASD. In addition, their synergistic action in molecules of aluminofluoride complexes can affect cell signaling, neurodevelopment, and CNS functions at several times lower concentrations than either Al3+ or fluoride acting alone. Our review opens the door to a number of new treatment modes that naturally reduce excitotoxicity and microglial priming." @default.
- W2801476600 created "2018-05-17" @default.
- W2801476600 creator A5014499599 @default.
- W2801476600 creator A5019898246 @default.
- W2801476600 creator A5040720875 @default.
- W2801476600 creator A5083252329 @default.
- W2801476600 date "2018-01-01" @default.
- W2801476600 modified "2023-10-10" @default.
- W2801476600 title "Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: A possible role of fluoride and aluminum" @default.
- W2801476600 cites W1182588605 @default.
- W2801476600 cites W1409858176 @default.
- W2801476600 cites W1498689470 @default.
- W2801476600 cites W1498791230 @default.
- W2801476600 cites W1515917630 @default.
- W2801476600 cites W1521404049 @default.
- W2801476600 cites W156121289 @default.
- W2801476600 cites W1562272706 @default.
- W2801476600 cites W1567217875 @default.
- W2801476600 cites W1576427485 @default.
- W2801476600 cites W1577847097 @default.
- W2801476600 cites W1594189146 @default.
- W2801476600 cites W1600525795 @default.
- W2801476600 cites W1601632182 @default.
- W2801476600 cites W1668344921 @default.
- W2801476600 cites W1802709990 @default.
- W2801476600 cites W1810539664 @default.
- W2801476600 cites W1822193713 @default.
- W2801476600 cites W1914782230 @default.
- W2801476600 cites W1930450098 @default.
- W2801476600 cites W1931173751 @default.
- W2801476600 cites W1950026089 @default.
- W2801476600 cites W1955481428 @default.
- W2801476600 cites W1963806203 @default.
- W2801476600 cites W1964216848 @default.
- W2801476600 cites W1966158216 @default.
- W2801476600 cites W1972117301 @default.
- W2801476600 cites W1972525575 @default.
- W2801476600 cites W1973350263 @default.
- W2801476600 cites W1973558071 @default.
- W2801476600 cites W1976451556 @default.
- W2801476600 cites W1976636874 @default.
- W2801476600 cites W1976824219 @default.
- W2801476600 cites W1978724750 @default.
- W2801476600 cites W1978757103 @default.
- W2801476600 cites W1980789245 @default.
- W2801476600 cites W1980865555 @default.
- W2801476600 cites W1982912347 @default.
- W2801476600 cites W1984112963 @default.
- W2801476600 cites W1986579353 @default.
- W2801476600 cites W1988854674 @default.
- W2801476600 cites W1991735683 @default.
- W2801476600 cites W1992417479 @default.
- W2801476600 cites W1993534837 @default.
- W2801476600 cites W1994710518 @default.
- W2801476600 cites W1996024251 @default.
- W2801476600 cites W1996087940 @default.
- W2801476600 cites W1999952543 @default.
- W2801476600 cites W2000087607 @default.
- W2801476600 cites W2000209474 @default.
- W2801476600 cites W2000939252 @default.
- W2801476600 cites W2001056499 @default.
- W2801476600 cites W2002632630 @default.
- W2801476600 cites W2002805664 @default.
- W2801476600 cites W2003058157 @default.
- W2801476600 cites W2004265420 @default.
- W2801476600 cites W2004402287 @default.
- W2801476600 cites W2005387911 @default.
- W2801476600 cites W2005614924 @default.
- W2801476600 cites W2005897950 @default.
- W2801476600 cites W2006762787 @default.
- W2801476600 cites W2010301460 @default.
- W2801476600 cites W2010621411 @default.
- W2801476600 cites W2011489640 @default.
- W2801476600 cites W2011672747 @default.
- W2801476600 cites W2011791885 @default.
- W2801476600 cites W2012006555 @default.
- W2801476600 cites W2014315244 @default.
- W2801476600 cites W2014510682 @default.
- W2801476600 cites W2016575029 @default.
- W2801476600 cites W2017827400 @default.
- W2801476600 cites W2018685944 @default.
- W2801476600 cites W2019845863 @default.
- W2801476600 cites W2019909669 @default.
- W2801476600 cites W2020374060 @default.
- W2801476600 cites W2022062383 @default.
- W2801476600 cites W2026211597 @default.
- W2801476600 cites W2028739632 @default.
- W2801476600 cites W2029190354 @default.
- W2801476600 cites W2030698122 @default.
- W2801476600 cites W2030926835 @default.
- W2801476600 cites W2031808078 @default.
- W2801476600 cites W2032011914 @default.
- W2801476600 cites W2032881377 @default.
- W2801476600 cites W2033617297 @default.
- W2801476600 cites W2033705578 @default.
- W2801476600 cites W2035339084 @default.
- W2801476600 cites W2035770994 @default.
- W2801476600 cites W2035798980 @default.