Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801478269> ?p ?o ?g. }
- W2801478269 endingPage "64" @default.
- W2801478269 startingPage "33" @default.
- W2801478269 abstract "Germline pharmacogenetics has so far mainly studied common variants in pharmacogenes, i.e., genes encoding drug metabolizing enzymes and transporters (DMET genes), certain auxiliary and regulatory genes, and drug target genes. Despite remarkable progress in understanding genetically determined differences in pharmacokinetics and pharmacodynamics of drugs, currently known common variants even in important pharmacogenes explain genetic variability only partially. This suggests missing heritability that may in part be due to rare variants in the classical pharmacogenes, but current evidence suggests that largely unexplored resources with potential for pharmacogenetics exist, both within already known pharmacogenes and in entirely new areas. In particular, recent studies suggest that epigenetic processes and noncoding RNAs, including mostly microRNAs (miRNAs), represent important and largely unexplored layers of DMET gene regulation that may fill some of the gaps in understanding interindividual variability and lead to new biomarkers. In this chapter we summarize recent advances in the understanding of genetic variability in epigenetic and miRNA-mediated processes with focus on their significance for DMET regulation and pharmacokinetic or pharmacological endpoints." @default.
- W2801478269 created "2018-05-17" @default.
- W2801478269 creator A5016331938 @default.
- W2801478269 creator A5044688765 @default.
- W2801478269 creator A5049364158 @default.
- W2801478269 creator A5083631711 @default.
- W2801478269 creator A5091429778 @default.
- W2801478269 date "2018-01-01" @default.
- W2801478269 modified "2023-09-23" @default.
- W2801478269 title "Epigenetics and MicroRNAs in Pharmacogenetics" @default.
- W2801478269 cites W1499220514 @default.
- W2801478269 cites W1501085035 @default.
- W2801478269 cites W1748873422 @default.
- W2801478269 cites W1774948393 @default.
- W2801478269 cites W1802946052 @default.
- W2801478269 cites W1899099918 @default.
- W2801478269 cites W1919545431 @default.
- W2801478269 cites W1965015745 @default.
- W2801478269 cites W1976760756 @default.
- W2801478269 cites W1982752167 @default.
- W2801478269 cites W1982891566 @default.
- W2801478269 cites W1984397688 @default.
- W2801478269 cites W1985825541 @default.
- W2801478269 cites W1987178620 @default.
- W2801478269 cites W1990665707 @default.
- W2801478269 cites W1993687973 @default.
- W2801478269 cites W2000341672 @default.
- W2801478269 cites W2010427019 @default.
- W2801478269 cites W2021034741 @default.
- W2801478269 cites W2027339324 @default.
- W2801478269 cites W2028582316 @default.
- W2801478269 cites W2030296267 @default.
- W2801478269 cites W2034456152 @default.
- W2801478269 cites W2039185379 @default.
- W2801478269 cites W2045206092 @default.
- W2801478269 cites W2047537378 @default.
- W2801478269 cites W2051674484 @default.
- W2801478269 cites W2053934130 @default.
- W2801478269 cites W2062779037 @default.
- W2801478269 cites W2072735166 @default.
- W2801478269 cites W2076604239 @default.
- W2801478269 cites W2080632752 @default.
- W2801478269 cites W2080834212 @default.
- W2801478269 cites W2082765638 @default.
- W2801478269 cites W2086098797 @default.
- W2801478269 cites W2086805204 @default.
- W2801478269 cites W2088140119 @default.
- W2801478269 cites W2093252196 @default.
- W2801478269 cites W2096106737 @default.
- W2801478269 cites W2099395832 @default.
- W2801478269 cites W2102958336 @default.
- W2801478269 cites W2103136667 @default.
- W2801478269 cites W2105100844 @default.
- W2801478269 cites W2105408170 @default.
- W2801478269 cites W2105763971 @default.
- W2801478269 cites W2108317100 @default.
- W2801478269 cites W2112170577 @default.
- W2801478269 cites W2114465406 @default.
- W2801478269 cites W2116868464 @default.
- W2801478269 cites W2117174177 @default.
- W2801478269 cites W2129711491 @default.
- W2801478269 cites W2131297071 @default.
- W2801478269 cites W2132813001 @default.
- W2801478269 cites W2133092029 @default.
- W2801478269 cites W2138980442 @default.
- W2801478269 cites W2139591401 @default.
- W2801478269 cites W2148667734 @default.
- W2801478269 cites W2149291473 @default.
- W2801478269 cites W2160273926 @default.
- W2801478269 cites W2162790862 @default.
- W2801478269 cites W2165124364 @default.
- W2801478269 cites W2173713488 @default.
- W2801478269 cites W2184810122 @default.
- W2801478269 cites W2185458335 @default.
- W2801478269 cites W2208906435 @default.
- W2801478269 cites W2220856990 @default.
- W2801478269 cites W2223928115 @default.
- W2801478269 cites W2252575358 @default.
- W2801478269 cites W2259750822 @default.
- W2801478269 cites W2263526750 @default.
- W2801478269 cites W2269974066 @default.
- W2801478269 cites W2275326120 @default.
- W2801478269 cites W2284577602 @default.
- W2801478269 cites W2315540614 @default.
- W2801478269 cites W2331496462 @default.
- W2801478269 cites W2357037093 @default.
- W2801478269 cites W2416252838 @default.
- W2801478269 cites W2463708289 @default.
- W2801478269 cites W2466965730 @default.
- W2801478269 cites W2501244830 @default.
- W2801478269 cites W2519784187 @default.
- W2801478269 cites W2586848209 @default.
- W2801478269 cites W2587781379 @default.
- W2801478269 cites W2601721987 @default.
- W2801478269 cites W2603379213 @default.
- W2801478269 cites W2604153406 @default.
- W2801478269 cites W2604722947 @default.
- W2801478269 cites W2604982871 @default.