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• W2801479820 abstract "<ns4:p><ns4:bold>Background</ns4:bold>: There are emerging reports of poor efficacy of artemisinin-based combination treatment (ACT). However, mutations on the Kelch-13 gene marking delayed parasite clearance have no clinically defined relationship with ACT resistance across Africa. With increasing malaria control efforts, declining acquired immunity could be responsible for varying drug response profiles that may be dependent on levels of exposure to infections. To examine antibody responses against malaria and the influence on the efficacy of artemether-lumefantrine (AL), plasma samples were collected, prior to treatment, from individuals presenting with uncomplicated malaria.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: Participants were stratified into two groups: early (within 24 hours, N = 20) and late (between 48 – 72 hours, N = 30) parasite clearance after treatment, as determined by <ns4:italic>var</ns4:italic> gene acidic terminal sequence (<ns4:italic>var</ns4:italic>ATS) polymerase chain reaction. Magnetic bead-based luminex assay was used to profile antibody responses specific to a panel of 21 <ns4:italic>Plasmodium falciparum</ns4:italic> sporozoite, merozoite and <ns4:italic>An. gambiae</ns4:italic> salivary antigens.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> Median fluorescence intensity (MFI) of the antibodies was highest against glutamate-rich protein (GLURP-R0) and lowest against merozoite surface protein (MSP2) antigen. Analysis showed a positive correlation between expression of immunity and age of individuals (P = 0.023). However, there was no association between parasite density and antibody responses, except a significant positive relationship with reticulocyte binding protein-like homologue 5 (Rh5), P = 0.047; <ns4:italic>Plasmodium</ns4:italic> exported protein (Hyp2), P = 0.037 and merozoite surface protein 11 (H103), P = 0.038. Though higher levels of antibodies against erythrocyte binding antigens (EBA 140 and 175), MSP1.19, GLURP, circumsporozoite protein (CSP) and Rh4.2 were observed in individuals who recorded early parasite clearance, there was no significant difference in antibody responses in the early and late parasitological response groups.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> Characterization of additional markers in larger populations is required to reveal potential immunological correlates of drug efficacy.</ns4:p>" @default.
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• W2801479820 date "2018-04-18" @default.
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• W2801479820 title "Assessing naturally acquired immune response and malaria treatment outcomes in Lagos, Nigeria" @default.
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• W2801479820 doi "https://doi.org/10.12688/aasopenres.12828.1" @default.
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