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- W2801479861 abstract "目的:探讨半胱天冬酶(caspase)活化途径是否在倍半萜烯内酯(SLs)诱导人鼻咽癌(NPC)细胞凋亡中起作用.方法:CNE1细胞株给予SLs的活性成分parthenolide(PN)处理,以及与caspase-3和-9特异性抑制剂联合作用进行caspase途径阻断实验,检测细胞内caspase-9和-3活性,观察其与细胞毒性和凋亡指标的关系.结果:PN作用后细胞TUNEL阳性率和SubG1细胞亚群增高,细胞失贴壁率和LDH漏出率显著增加(P＜0.05),但caspase-9和-3活性未见升高.特异性抑制剂作用后caspase活性明显降低(P＜0.05),而细胞凋亡和毒性指标未见明显改变.结论:提示PN诱导CNE1细胞凋亡作用与其细胞毒性效应有关,与caspase活化途径无关." @default.
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- W2801479861 date "2003-01-01" @default.
- W2801479861 modified "2023-09-28" @default.
- W2801479861 title "PARTHENOLIDE INDUCES APOPTOSIS IN HUMAN NASOPHARYNGEAL CARCINOMA CNE1 CELL LINE VIA NON-CASPASE-ACTIVATION PATHWAY" @default.
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