Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801494816> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2801494816 endingPage "53" @default.
- W2801494816 startingPage "42" @default.
- W2801494816 abstract "Aim The postoperative healing of the cystic cavity was chosen as experimental model of bone regeneration. The morphological, cellular and molecular events characterizing the stages of regeneration, from the clot to the bone formation within the cystic cavity were investigated. Materials and methods Samples of regenerating tissue taken 15 days, 1, 2 and 4 months after surgery were analyzed. A total of 8 samples were collected, 4 of which were from the same patient (longitudinal study) and 4 from different patients (cross-sectional study). The investigations performed were: SEM analysis of all samples; transmission electron microscopy of samples taken after 15 days and 1 month; primary cell cultures of samples taken after 15 days and 1 month; Western blotting of cell lysates to highlight the presence of proteins characteristic of osteoblasts, such as osteocalcin, BMP2 and transglutaminase. Clinical and radiographic examinations completed the analyses. Results Results confirm that a spontaneous bone regeneration occurs after enucleation of jaw cysts, even in patients with large bone defects. The bone healing process is slow, in particular bone maturation, which is still not completed after 4 months. Remodeling of the matrix begins after 15 days and is evident after 1 month, also demonstrated by the high expression level of transglutaminase in the preosteoblastic cells isolated from the samples. The first phase of bone healing, characterized by an osteoid matrix replacing the osteo-coagulum, can be considered completed after about 2 months. Conclusion The basic conditions for spontaneous bone regeneration are: migration of undifferentiated mesenchymal cells from the overhanging periosteum and of osteoblasts from the surrounding endostium; fibrin matrix supporting the amplification and the differentiation of pluripotent mesenchymal cells; cooperation of platelets, macrophages and immunocompetent cells; significant neoangiogenesis ensuring new tissue vascularization." @default.
- W2801494816 created "2018-05-17" @default.
- W2801494816 creator A5016373532 @default.
- W2801494816 creator A5016625969 @default.
- W2801494816 creator A5038069974 @default.
- W2801494816 creator A5045800539 @default.
- W2801494816 creator A5062991742 @default.
- W2801494816 creator A5086197809 @default.
- W2801494816 creator A5089902423 @default.
- W2801494816 date "2009-08-30" @default.
- W2801494816 modified "2023-09-28" @default.
- W2801494816 title "A model of human bone regeneration: morphological, cellular and molecular aspects" @default.
- W2801494816 doi "https://doi.org/10.23805/jo.2009.01.02.01" @default.
- W2801494816 hasPublicationYear "2009" @default.
- W2801494816 type Work @default.
- W2801494816 sameAs 2801494816 @default.
- W2801494816 citedByCount "0" @default.
- W2801494816 crossrefType "journal-article" @default.
- W2801494816 hasAuthorship W2801494816A5016373532 @default.
- W2801494816 hasAuthorship W2801494816A5016625969 @default.
- W2801494816 hasAuthorship W2801494816A5038069974 @default.
- W2801494816 hasAuthorship W2801494816A5045800539 @default.
- W2801494816 hasAuthorship W2801494816A5062991742 @default.
- W2801494816 hasAuthorship W2801494816A5086197809 @default.
- W2801494816 hasAuthorship W2801494816A5089902423 @default.
- W2801494816 hasConcept C105702510 @default.
- W2801494816 hasConcept C131075544 @default.
- W2801494816 hasConcept C141071460 @default.
- W2801494816 hasConcept C142724271 @default.
- W2801494816 hasConcept C160160445 @default.
- W2801494816 hasConcept C171056886 @default.
- W2801494816 hasConcept C181199279 @default.
- W2801494816 hasConcept C185592680 @default.
- W2801494816 hasConcept C188261085 @default.
- W2801494816 hasConcept C198826908 @default.
- W2801494816 hasConcept C2777674748 @default.
- W2801494816 hasConcept C55493867 @default.
- W2801494816 hasConcept C71924100 @default.
- W2801494816 hasConcept C81880429 @default.
- W2801494816 hasConcept C8337478 @default.
- W2801494816 hasConcept C86803240 @default.
- W2801494816 hasConcept C95444343 @default.
- W2801494816 hasConceptScore W2801494816C105702510 @default.
- W2801494816 hasConceptScore W2801494816C131075544 @default.
- W2801494816 hasConceptScore W2801494816C141071460 @default.
- W2801494816 hasConceptScore W2801494816C142724271 @default.
- W2801494816 hasConceptScore W2801494816C160160445 @default.
- W2801494816 hasConceptScore W2801494816C171056886 @default.
- W2801494816 hasConceptScore W2801494816C181199279 @default.
- W2801494816 hasConceptScore W2801494816C185592680 @default.
- W2801494816 hasConceptScore W2801494816C188261085 @default.
- W2801494816 hasConceptScore W2801494816C198826908 @default.
- W2801494816 hasConceptScore W2801494816C2777674748 @default.
- W2801494816 hasConceptScore W2801494816C55493867 @default.
- W2801494816 hasConceptScore W2801494816C71924100 @default.
- W2801494816 hasConceptScore W2801494816C81880429 @default.
- W2801494816 hasConceptScore W2801494816C8337478 @default.
- W2801494816 hasConceptScore W2801494816C86803240 @default.
- W2801494816 hasConceptScore W2801494816C95444343 @default.
- W2801494816 hasIssue "2" @default.
- W2801494816 hasLocation W28014948161 @default.
- W2801494816 hasOpenAccess W2801494816 @default.
- W2801494816 hasPrimaryLocation W28014948161 @default.
- W2801494816 hasRelatedWork W197084182 @default.
- W2801494816 hasRelatedWork W1975028847 @default.
- W2801494816 hasRelatedWork W2022845905 @default.
- W2801494816 hasRelatedWork W2066951919 @default.
- W2801494816 hasRelatedWork W2109846255 @default.
- W2801494816 hasRelatedWork W2154790263 @default.
- W2801494816 hasRelatedWork W2169267041 @default.
- W2801494816 hasRelatedWork W2350760899 @default.
- W2801494816 hasRelatedWork W2353592703 @default.
- W2801494816 hasRelatedWork W2353951604 @default.
- W2801494816 hasRelatedWork W2357566951 @default.
- W2801494816 hasRelatedWork W2363080660 @default.
- W2801494816 hasRelatedWork W2364560501 @default.
- W2801494816 hasRelatedWork W2399276294 @default.
- W2801494816 hasRelatedWork W2409504181 @default.
- W2801494816 hasRelatedWork W2429265738 @default.
- W2801494816 hasRelatedWork W2516254211 @default.
- W2801494816 hasRelatedWork W2525235767 @default.
- W2801494816 hasRelatedWork W2966304576 @default.
- W2801494816 hasRelatedWork W2605672071 @default.
- W2801494816 hasVolume "1" @default.
- W2801494816 isParatext "false" @default.
- W2801494816 isRetracted "false" @default.
- W2801494816 magId "2801494816" @default.
- W2801494816 workType "article" @default.