FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801497388> ?p ?o ?g. }

• W2801497388 abstract "Cells release membrane enclosed nano-sized vesicles termed extracellular vesicles (EVs) that function as mediators of intercellular communication by transferring biological information between cells. Tumor-derived EVs have emerged as important mediators in cancer development and progression, mainly through transfer of their bioactive content which can include oncoproteins, oncogenes, chemokine receptors as well as soluble factors, transcripts of proteins and miRNAs involved in angiogenesis or inflammation. This transfer has been shown to influence the metastatic behavior of primary tumors. Moreover, tumor-derived EVs have been shown to influence distant cellular niches, establishing favorable microenvironments that support growth of disseminated cancer cells upon their arrival at these pre-metastatic niches. It is generally accepted that cells release a number of major extracellular vesicle (EV) populations with distinct biophysical properties and biological functions. Exosomes (EXOs), microvesicles (MVs) and apoptotic bodies (APOs) are EV populations most widely studied and characterized. They are discriminated based primarily on their intracellular origin. However, increasing evidence suggests that even within these EV populations various subpopulations may exist. This heterogeneity introduces an extra level of complexity in the study of EV biology and function. For example, EV subpopulations could have unique roles in the intricate biological processes underlying cancer biology. Here, we discuss current knowledge regarding the role of subpopulations of EVs in cancer development and progression and highlight the relevance of EV heterogeneity. The position of tetraspanins and integrins therein will be highlighted. Since addressing EV heterogeneity has become essential for the EV field, current and novel techniques for isolating EV subpopulations will also be discussed. Further dissection of EV heterogeneity will advance our understanding of the critical roles of EVs in health and disease." @default.
• W2801497388 created "2018-05-17" @default.
• W2801497388 creator A5013415392 @default.
• W2801497388 creator A5079355181 @default.
• W2801497388 creator A5081942571 @default.
• W2801497388 creator A5089279578 @default.
• W2801497388 creator A5090436131 @default.
• W2801497388 date "2018-04-30" @default.
• W2801497388 modified "2023-10-16" @default.
• W2801497388 title "Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression" @default.
• W2801497388 cites W136971731 @default.
• W2801497388 cites W1506174710 @default.
• W2801497388 cites W1522977578 @default.
• W2801497388 cites W1534453667 @default.
• W2801497388 cites W1555041989 @default.
• W2801497388 cites W1566386955 @default.
• W2801497388 cites W1578844443 @default.
• W2801497388 cites W1589968217 @default.
• W2801497388 cites W1600015917 @default.
• W2801497388 cites W1601681275 @default.
• W2801497388 cites W1682077723 @default.
• W2801497388 cites W1793480972 @default.
• W2801497388 cites W1824478393 @default.
• W2801497388 cites W1835592430 @default.
• W2801497388 cites W1850622634 @default.
• W2801497388 cites W1877686344 @default.
• W2801497388 cites W1915536483 @default.
• W2801497388 cites W1924064381 @default.
• W2801497388 cites W1950118853 @default.
• W2801497388 cites W1959468401 @default.
• W2801497388 cites W1964232997 @default.
• W2801497388 cites W1965913620 @default.
• W2801497388 cites W1966790817 @default.
• W2801497388 cites W1967367827 @default.
• W2801497388 cites W1972070926 @default.
• W2801497388 cites W1974113689 @default.
• W2801497388 cites W1975859224 @default.
• W2801497388 cites W1977208217 @default.
• W2801497388 cites W1977417275 @default.
• W2801497388 cites W1977716161 @default.
• W2801497388 cites W1979751563 @default.
• W2801497388 cites W1982606786 @default.
• W2801497388 cites W1985727076 @default.
• W2801497388 cites W1986321004 @default.
• W2801497388 cites W1989090719 @default.
• W2801497388 cites W1989515923 @default.
• W2801497388 cites W1991935485 @default.
• W2801497388 cites W1993140699 @default.
• W2801497388 cites W1994344811 @default.
• W2801497388 cites W1994668150 @default.
• W2801497388 cites W1995827114 @default.
• W2801497388 cites W1998079639 @default.
• W2801497388 cites W1998459062 @default.
• W2801497388 cites W2001849319 @default.
• W2801497388 cites W2002416967 @default.
• W2801497388 cites W2003343932 @default.
• W2801497388 cites W2005993715 @default.
• W2801497388 cites W2008182723 @default.
• W2801497388 cites W2008238182 @default.
• W2801497388 cites W2009649000 @default.
• W2801497388 cites W2010821717 @default.
• W2801497388 cites W2012528990 @default.
• W2801497388 cites W2013094398 @default.
• W2801497388 cites W2017059044 @default.
• W2801497388 cites W2018106032 @default.
• W2801497388 cites W2020863352 @default.
• W2801497388 cites W2026867370 @default.
• W2801497388 cites W2028248159 @default.
• W2801497388 cites W2029735360 @default.
• W2801497388 cites W2030701238 @default.
• W2801497388 cites W2036073789 @default.
• W2801497388 cites W2038236600 @default.
• W2801497388 cites W2038363115 @default.
• W2801497388 cites W2048883725 @default.
• W2801497388 cites W2049074403 @default.
• W2801497388 cites W2049369927 @default.
• W2801497388 cites W2051222468 @default.
• W2801497388 cites W2053702156 @default.
• W2801497388 cites W2055313665 @default.
• W2801497388 cites W2065011123 @default.
• W2801497388 cites W2065944432 @default.
• W2801497388 cites W2068358300 @default.
• W2801497388 cites W2071188263 @default.
• W2801497388 cites W2073341747 @default.
• W2801497388 cites W2073706234 @default.
• W2801497388 cites W2075418079 @default.
• W2801497388 cites W2076315676 @default.
• W2801497388 cites W2077773656 @default.
• W2801497388 cites W2080879611 @default.
• W2801497388 cites W2081124475 @default.
• W2801497388 cites W2086612059 @default.
• W2801497388 cites W2090142958 @default.
• W2801497388 cites W2091042344 @default.
• W2801497388 cites W2091868933 @default.
• W2801497388 cites W2093013992 @default.
• W2801497388 cites W2096794442 @default.
• W2801497388 cites W2101185555 @default.
• W2801497388 cites W2102440571 @default.
• W2801497388 cites W2107967984 @default.
• W2801497388 cites W2109564400 @default.

• next