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- W2801507940 endingPage "152" @default.
- W2801507940 startingPage "140" @default.
- W2801507940 abstract "Interferon gamma (IFN-γ) is one of the key players in the immune system of vertebrates. The evolution and properties of IFN-γ and its receptors in fish species are of special interest as they point to the origin of innate immunity in vertebrates. We studied the phylogeny, biophysical and structural properties of IFN-γ and its receptors. Our phylogeny analysis suggests the existence of two groups of IFN-γ related proteins, one specific for Acanthomorpha, the other for Cypriniformes, Characiformes and Siluriformes. The analysis further shows an ancient duplication of the gene for IFN-γ receptor 1 (IFN- γR1) and the parallel existence of the duplicated genes in all current teleost fish species. In contrast, only one gene can be found for receptor 2, IFN- γR2. The specificity of the interaction between IFN- γ and both types of IFN- γR1 was determined by microscale thermophoresis measurements of the equilibrium dissociation constants for the proteins from three fish species. The measured preference of IFN- γ for one of the two forms of receptor 1agrees with the bioinformatic analysis of the coevolution between IFN- γ and receptor 1. To elucidate structural relationships between IFN-γ of fish and other vertebrate species, we determined the crystal structure of IFN-γ from olive flounder (Paralichthys olivaceus, PoliIFN-γ) at crystallographic resolution of 2.3 Å and the low-resolution structures of Takifugu rubripes, Oreochromis niloticus, and Larimichthys crocea IFN-γ by small angle X-ray diffraction. The overall PoliIFN-γ fold is the same as the fold of the other known IFN- γ structures but there are some significant structural differences, namely the additional C-terminal helix G and a different angle between helices C and D in PoliIFN-γ." @default.
- W2801507940 created "2018-05-17" @default.
- W2801507940 creator A5007273860 @default.
- W2801507940 creator A5017944702 @default.
- W2801507940 creator A5022441203 @default.
- W2801507940 creator A5079867847 @default.
- W2801507940 creator A5079948655 @default.
- W2801507940 date "2018-08-01" @default.
- W2801507940 modified "2023-09-27" @default.
- W2801507940 title "Interferons type II and their receptors R1 and R2 in fish species: Evolution, structure, and function" @default.
- W2801507940 cites W1482158720 @default.
- W2801507940 cites W1507974398 @default.
- W2801507940 cites W1528814602 @default.
- W2801507940 cites W1530235393 @default.
- W2801507940 cites W1558270545 @default.
- W2801507940 cites W1568438452 @default.
- W2801507940 cites W1605984840 @default.
- W2801507940 cites W1628398088 @default.
- W2801507940 cites W1767772592 @default.
- W2801507940 cites W1869207333 @default.
- W2801507940 cites W1969115256 @default.
- W2801507940 cites W1971439989 @default.
- W2801507940 cites W1972073034 @default.
- W2801507940 cites W1977038370 @default.
- W2801507940 cites W1977715087 @default.
- W2801507940 cites W1980374511 @default.
- W2801507940 cites W1980973382 @default.
- W2801507940 cites W1982126789 @default.
- W2801507940 cites W1982516668 @default.
- W2801507940 cites W1982856405 @default.
- W2801507940 cites W1987194790 @default.
- W2801507940 cites W1992471058 @default.
- W2801507940 cites W1994678939 @default.
- W2801507940 cites W1996058720 @default.
- W2801507940 cites W1996841578 @default.
- W2801507940 cites W1999240709 @default.
- W2801507940 cites W2002972674 @default.
- W2801507940 cites W2004583149 @default.
- W2801507940 cites W2006337065 @default.
- W2801507940 cites W2008208329 @default.
- W2801507940 cites W2013958910 @default.
- W2801507940 cites W2017132247 @default.
- W2801507940 cites W2022097289 @default.
- W2801507940 cites W2026639904 @default.
- W2801507940 cites W2026691407 @default.
- W2801507940 cites W2029303000 @default.
- W2801507940 cites W2033856426 @default.
- W2801507940 cites W2034499270 @default.
- W2801507940 cites W2035145355 @default.
- W2801507940 cites W2038912152 @default.
- W2801507940 cites W2047227989 @default.
- W2801507940 cites W2047544230 @default.
- W2801507940 cites W2052749821 @default.
- W2801507940 cites W2053164681 @default.
- W2801507940 cites W2055043387 @default.
- W2801507940 cites W2060926084 @default.
- W2801507940 cites W2061041720 @default.
- W2801507940 cites W2063044697 @default.
- W2801507940 cites W2063897424 @default.
- W2801507940 cites W2065283382 @default.
- W2801507940 cites W2068925537 @default.
- W2801507940 cites W2071191299 @default.
- W2801507940 cites W2074664341 @default.
- W2801507940 cites W2075574194 @default.
- W2801507940 cites W2077442585 @default.
- W2801507940 cites W2078844752 @default.
- W2801507940 cites W2081778808 @default.
- W2801507940 cites W2084486673 @default.
- W2801507940 cites W2086082257 @default.
- W2801507940 cites W2087011643 @default.
- W2801507940 cites W2089047063 @default.
- W2801507940 cites W2093481978 @default.
- W2801507940 cites W2095540469 @default.
- W2801507940 cites W2108921801 @default.
- W2801507940 cites W2109523152 @default.
- W2801507940 cites W2110808180 @default.
- W2801507940 cites W2111211467 @default.
- W2801507940 cites W2113916199 @default.
- W2801507940 cites W2114520383 @default.
- W2801507940 cites W2115888213 @default.
- W2801507940 cites W2124026197 @default.
- W2801507940 cites W2126718812 @default.
- W2801507940 cites W2127594598 @default.
- W2801507940 cites W2127860913 @default.
- W2801507940 cites W2128060197 @default.
- W2801507940 cites W2131322950 @default.
- W2801507940 cites W2132629607 @default.
- W2801507940 cites W2132926880 @default.
- W2801507940 cites W2137400422 @default.
- W2801507940 cites W2137979020 @default.
- W2801507940 cites W2138798117 @default.
- W2801507940 cites W2142431990 @default.
- W2801507940 cites W2143306786 @default.
- W2801507940 cites W2144654387 @default.
- W2801507940 cites W2146247267 @default.
- W2801507940 cites W2151409320 @default.
- W2801507940 cites W2152770371 @default.
- W2801507940 cites W2154035365 @default.