FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801542932> ?p ?o ?g. }

• W2801542932 endingPage "1329" @default.
• W2801542932 startingPage "1329" @default.
• W2801542932 abstract "Fluoxetine (Flx) is a selective serotonin reuptake inhibitor that alters the male reproductive system when administered at the adult stage or after maternal exposure. In the present study we evaluated the effects of Flx administration on reproductive parameters during juvenile-peripubertal development when treated male rats reached adulthood. Groups of rats were treated daily with Flx (5mgkg-1, i.p.) or saline (0.9% NaCl), or were left untreated. Rats were treated between 30 and 53 days of age and were killed at 65 days of age. Serotonin concentrations were determined in the hypothalamus, hypophysis and testis. Gonadotrophins, sex steroids and sperm quality (membrane integrity, sperm with functional mitochondria, sperm density, sperm motility and morphological abnormalities) were also evaluated. Flx did not affect bodyweight, but significantly diminished LH, FSH, progesterone and testosterone serum concentrations. After graphical analysis, a subgroup of rats was identified whose sperm quality parameters were greatly affected by Flx. In the present study we show that Flx administered to juvenile rats disrupts the hypothalamic-hypophyseal-testicular axis and its effects on sperm quality are not homogeneous in adults. In contrast, Flx altered concentrations of gonadotrophins and sexual steroids in all treated rats. These results suggest caution should be exercised in the prescription of Flx to prepubertal males." @default.
• W2801542932 created "2018-05-17" @default.
• W2801542932 creator A5024996299 @default.
• W2801542932 creator A5054402965 @default.
• W2801542932 creator A5083240741 @default.
• W2801542932 creator A5089163841 @default.
• W2801542932 date "2018-01-01" @default.
• W2801542932 modified "2023-10-01" @default.
• W2801542932 title "Fluoxetine treatment of prepubertal male rats uniformly diminishes sex hormone levels and, in a subpopulation of animals, negatively affects sperm quality" @default.
• W2801542932 cites W1645533628 @default.
• W2801542932 cites W1895691359 @default.
• W2801542932 cites W1963718271 @default.
• W2801542932 cites W1971473486 @default.
• W2801542932 cites W1972039019 @default.
• W2801542932 cites W1974934611 @default.
• W2801542932 cites W1977288231 @default.
• W2801542932 cites W1979452048 @default.
• W2801542932 cites W1987615033 @default.
• W2801542932 cites W1994016972 @default.
• W2801542932 cites W1995223022 @default.
• W2801542932 cites W2001969215 @default.
• W2801542932 cites W2005312774 @default.
• W2801542932 cites W2005914706 @default.
• W2801542932 cites W2011365548 @default.
• W2801542932 cites W2013366988 @default.
• W2801542932 cites W2021894419 @default.
• W2801542932 cites W2022026140 @default.
• W2801542932 cites W2022725540 @default.
• W2801542932 cites W2022907863 @default.
• W2801542932 cites W2023748980 @default.
• W2801542932 cites W2032914176 @default.
• W2801542932 cites W2033125611 @default.
• W2801542932 cites W2033234811 @default.
• W2801542932 cites W2033960000 @default.
• W2801542932 cites W2034396455 @default.
• W2801542932 cites W2040322827 @default.
• W2801542932 cites W2046438679 @default.
• W2801542932 cites W2049842274 @default.
• W2801542932 cites W2052805429 @default.
• W2801542932 cites W2054181034 @default.
• W2801542932 cites W2054227830 @default.
• W2801542932 cites W2059433273 @default.
• W2801542932 cites W2064626642 @default.
• W2801542932 cites W2064997609 @default.
• W2801542932 cites W2065365546 @default.
• W2801542932 cites W2068586063 @default.
• W2801542932 cites W2069385885 @default.
• W2801542932 cites W2073152512 @default.
• W2801542932 cites W2074990442 @default.
• W2801542932 cites W2078092660 @default.
• W2801542932 cites W2082080632 @default.
• W2801542932 cites W2083894864 @default.
• W2801542932 cites W2084533142 @default.
• W2801542932 cites W2087019986 @default.
• W2801542932 cites W2087535382 @default.
• W2801542932 cites W2090977130 @default.
• W2801542932 cites W2093514511 @default.
• W2801542932 cites W2094073058 @default.
• W2801542932 cites W2094202407 @default.
• W2801542932 cites W2099384996 @default.
• W2801542932 cites W2107750991 @default.
• W2801542932 cites W2108897841 @default.
• W2801542932 cites W2115945717 @default.
• W2801542932 cites W2132011757 @default.
• W2801542932 cites W2137769712 @default.
• W2801542932 cites W2138624097 @default.
• W2801542932 cites W2145680370 @default.
• W2801542932 cites W2146431823 @default.
• W2801542932 cites W2147123192 @default.
• W2801542932 cites W2150464882 @default.
• W2801542932 cites W2150552919 @default.
• W2801542932 cites W2153619271 @default.
• W2801542932 cites W2155964805 @default.
• W2801542932 cites W2167945809 @default.
• W2801542932 cites W2169997480 @default.
• W2801542932 cites W2190619282 @default.
• W2801542932 cites W2320930814 @default.
• W2801542932 cites W2584401931 @default.
• W2801542932 doi "https://doi.org/10.1071/rd17384" @default.
• W2801542932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29706148" @default.
• W2801542932 hasPublicationYear "2018" @default.
• W2801542932 type Work @default.
• W2801542932 sameAs 2801542932 @default.
• W2801542932 citedByCount "8" @default.
• W2801542932 countsByYear W28015429322019 @default.
• W2801542932 countsByYear W28015429322020 @default.
• W2801542932 countsByYear W28015429322021 @default.
• W2801542932 countsByYear W28015429322022 @default.
• W2801542932 countsByYear W28015429322023 @default.
• W2801542932 crossrefType "journal-article" @default.
• W2801542932 hasAuthorship W2801542932A5024996299 @default.
• W2801542932 hasAuthorship W2801542932A5054402965 @default.
• W2801542932 hasAuthorship W2801542932A5083240741 @default.
• W2801542932 hasAuthorship W2801542932A5089163841 @default.
• W2801542932 hasConcept C126322002 @default.
• W2801542932 hasConcept C134018914 @default.
• W2801542932 hasConcept C16685009 @default.
• W2801542932 hasConcept C170493617 @default.

• next