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- W280154739 abstract "This experiment was designed to examine the effects of progesterone on endogenous and oxytocin-induced secretion of prostaglandin F2α (PGF2α) in sows. Peripheral concentrations of 13,14-dihydro-15-keto-PGF2α (PGFM) were used as an indirect measure of uterine PGF2α secretion. Eight sows received twice daily injections of progesterone (160 mg/injection) on d 1 to 5 after estrus. Another eight sows received comparable injections of a corn oil injection vehicle. Each sow then received i.v. injections of oxytocin (30 IU) on d 10, 12, and 15 after estrus. Concentrations of PGFM were determined in jugular venous blood samples collected at −60, −45, −30, −15, 0, 2, 5, 10, 15, 30, 45, 60, 90, and 120 min after each oxytocin injection. The mean concentrations of PGFM in samples collected before injection of oxytocin (baseline), the magnitude of the PGFM response to oxytocin, and the area under the PGFM response curve (AUC) were calculated for the three oxytocin challenges administered to each sow. Baseline, magnitude, and AUC were low on d 10 after estrus and similar for the two treatment groups. On d 12 baseline, magnitude, and AUC remained low in the control sows; however, all three response variables increased in sows that received progesterone. By d 15, all three variables were high and similar in both treatment groups. In conclusion, progesterone, administered early in the estrous cycle, seems to promote premature secretion of PGF2α as indicated by the high basal concentrations of PGFM observed before injection of oxytocin on d 12.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
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- W280154739 date "1994-02-01" @default.
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- W280154739 title "Changes in peripheral concentrations of 13,14-dihydro-15-keto-prostaglandin F2α induced by progesterone in swine1" @default.
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- W280154739 doi "https://doi.org/10.2527/1994.722459x" @default.
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