FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801565572> ?p ?o ?g. }

• W2801565572 endingPage "1043" @default.
• W2801565572 startingPage "1034" @default.
• W2801565572 abstract "The gene encoding phosphatidylinositol-4-phosphate 5-kinase (PIP5K1C) has been recently implicated in pain regulation. Interestingly, a recent cross-tissue and cross-phenotypic epigenetic analysis identified the same gene in alcohol use disorder (AUD). Given the high comorbidity between AUD and chronic pain, we hypothesized that genetic variation in PIP5K1C might contribute to susceptibility to AUD.We conducted a case-control association study of genetic variants in PIP5K1C. Association analyses of 16 common PIP5K1C single nucleotide polymorphisms (SNPs) were conducted in cases and controls of African (427 cases and 137 controls) and European ancestry (488 cases and 324 controls) using standard methods. In addition, given the prominent role of the opioid system in pain signaling, we investigated the effects of acute alcohol exposure on PIP5K1C expression in humanized transgenic mice for the μ-opioid receptor that included the OPRM1 A118G polymorphism, a widely used mouse model to study analgesic response to opioids in pain. PIP5K1C expression was measured in the thalamus and basolateral amygdala (BLA) in mice after short-term administration (single 2 g/kg dose) of alcohol or saline using immunohistochemistry and analyzed by 2-way analysis of variance.In the case-control association study using an NIAAA discovery sample, 8 SNPs in PIP5K1C were significantly associated with AUD in the African ancestry (AA) group (p < 0.05 after correction; rs4807493, rs10405681, rs2074957, rs10432303, rs8109485, rs1476592, rs10419980, and rs4432372). However, a replication analysis using an independent sample (N = 3,801) found no significant associations after correction for multiple testing. In the humanized transgenic mouse model with the OPRM1 polymorphism, PIP5K1C expression was significantly different between alcohol and saline-treated mice, regardless of genotype, in both the thalamus (p < 0.05) and BLA (p < 0.01).Our discovery sample shows that genetic variants in PIP5K1C are associated with AUD in the AA group, and acute alcohol exposure leads to up-regulation of PIP5K1C, potentially explaining a mechanism underlying the increased risk for chronic pain conditions in individuals with AUD." @default.
• W2801565572 created "2018-05-17" @default.
• W2801565572 creator A5012492362 @default.
• W2801565572 creator A5012527971 @default.
• W2801565572 creator A5023738842 @default.
• W2801565572 creator A5035193495 @default.
• W2801565572 creator A5054033636 @default.
• W2801565572 creator A5060306682 @default.
• W2801565572 creator A5066140694 @default.
• W2801565572 creator A5075112055 @default.
• W2801565572 creator A5076023932 @default.
• W2801565572 creator A5082397651 @default.
• W2801565572 creator A5089297041 @default.
• W2801565572 creator A5089957785 @default.
• W2801565572 creator A5091096520 @default.
• W2801565572 creator A5091480548 @default.
• W2801565572 creator A5091625941 @default.
• W2801565572 date "2018-05-09" @default.
• W2801565572 modified "2023-10-15" @default.
• W2801565572 title "Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use" @default.
• W2801565572 cites W1475474724 @default.
• W2801565572 cites W1533942137 @default.
• W2801565572 cites W1560013893 @default.
• W2801565572 cites W1569173481 @default.
• W2801565572 cites W1586669490 @default.
• W2801565572 cites W1839921965 @default.
• W2801565572 cites W1964524363 @default.
• W2801565572 cites W1966303573 @default.
• W2801565572 cites W1966540175 @default.
• W2801565572 cites W1968242570 @default.
• W2801565572 cites W1970248850 @default.
• W2801565572 cites W1971240136 @default.
• W2801565572 cites W1975327913 @default.
• W2801565572 cites W1976153901 @default.
• W2801565572 cites W1976960945 @default.
• W2801565572 cites W1977436056 @default.
• W2801565572 cites W1982532032 @default.
• W2801565572 cites W1994285916 @default.
• W2801565572 cites W1996880759 @default.
• W2801565572 cites W1998846966 @default.
• W2801565572 cites W2001470706 @default.
• W2801565572 cites W2008769416 @default.
• W2801565572 cites W2013933057 @default.
• W2801565572 cites W2016124588 @default.
• W2801565572 cites W2024968911 @default.
• W2801565572 cites W2028499734 @default.
• W2801565572 cites W2030123928 @default.
• W2801565572 cites W2034763673 @default.
• W2801565572 cites W2036286128 @default.
• W2801565572 cites W2042334179 @default.
• W2801565572 cites W2045284958 @default.
• W2801565572 cites W2049583185 @default.
• W2801565572 cites W2050489286 @default.
• W2801565572 cites W2050912412 @default.
• W2801565572 cites W2056189730 @default.
• W2801565572 cites W2058510259 @default.
• W2801565572 cites W2058878920 @default.
• W2801565572 cites W2066796289 @default.
• W2801565572 cites W2070141017 @default.
• W2801565572 cites W2072275710 @default.
• W2801565572 cites W2072276782 @default.
• W2801565572 cites W2073014088 @default.
• W2801565572 cites W2075527287 @default.
• W2801565572 cites W2078382471 @default.
• W2801565572 cites W2078498078 @default.
• W2801565572 cites W2083868954 @default.
• W2801565572 cites W2085146359 @default.
• W2801565572 cites W2085277613 @default.
• W2801565572 cites W2093559862 @default.
• W2801565572 cites W2097354530 @default.
• W2801565572 cites W2104538950 @default.
• W2801565572 cites W2118061336 @default.
• W2801565572 cites W2122693280 @default.
• W2801565572 cites W2123282949 @default.
• W2801565572 cites W2124989505 @default.
• W2801565572 cites W2125199618 @default.
• W2801565572 cites W2126405975 @default.
• W2801565572 cites W2126751026 @default.
• W2801565572 cites W2135592475 @default.
• W2801565572 cites W2141281556 @default.
• W2801565572 cites W2148960697 @default.
• W2801565572 cites W2151247004 @default.
• W2801565572 cites W2156364581 @default.
• W2801565572 cites W2160397887 @default.
• W2801565572 cites W2161633633 @default.
• W2801565572 cites W2162530578 @default.
• W2801565572 cites W2163686172 @default.
• W2801565572 cites W2244168799 @default.
• W2801565572 cites W2319089646 @default.
• W2801565572 cites W2412078313 @default.
• W2801565572 cites W2500077069 @default.
• W2801565572 cites W2581829687 @default.
• W2801565572 cites W2752652639 @default.
• W2801565572 cites W4212862987 @default.
• W2801565572 cites W4232615320 @default.
• W2801565572 cites W4247665917 @default.
• W2801565572 cites W4376849345 @default.
• W2801565572 doi "https://doi.org/10.1111/acer.13751" @default.

• next