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- W2801577419 abstract "Labeled cells in the host retina following transplantation of reporter-labeled donor cells were thought to arise from donor cell migration and engraftment into the tissue, but more recently this interpretation has been challenged with new findings that material transfer occurs between host and donor photoreceptors. In-vivo studies are laborious and impractical to investigate the mechanisms of cell engraftment. As such, we have developed a simpler in-vitro assay that uses retinal organoids to monitor photoreceptor precursor engraftment. Dissociated retinal cells have the propensity to self-organize and form spherical laminated structures or organoids that have features in common with normal retinal organization. Here, we characterize the cellular composition and the cell type requirement for efficient organoid formation. We have further developed an engraftment assay, established a cell integration baseline and shown the application of this assay to models of retinal degeneration.%%%%M.Sc." @default.
- W2801577419 created "2018-05-17" @default.
- W2801577419 creator A5026025977 @default.
- W2801577419 date "2017-11-01" @default.
- W2801577419 modified "2023-09-27" @default.
- W2801577419 title "Development of an In-vitro Organoid Assay to Study Engraftment of Photoreceptor Precursors" @default.
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