FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801597267> ?p ?o ?g. }

• W2801597267 endingPage "371" @default.
• W2801597267 startingPage "364" @default.
• W2801597267 abstract "The dentato-rubro-thalamic tract (DRTT) regulates motor control, connecting the cerebellum to the thalamus. This tract is modulated by deep-brain stimulation in the surgical treatment of medically refractory tremor, especially in essential tremor, where high-frequency stimulation of the thalamus can improve symptoms. The DRTT is classically described as a decussating pathway, ascending to the contralateral thalamus. However, the existence of a nondecussating (i.e. ipsilateral) DRTT in humans was recently demonstrated, and these tracts are arranged in distinct regions of the superior cerebellar peduncle. We hypothesized that the ipsilateral DRTT is connected to specific thalamic nuclei and therefore may have unique functional relevance. The goals of this study were to confirm the presence of the decussating and nondecussating DRTT pathways, identify thalamic termination zones of each tract, and compare whether structural connectivity findings agree with functional connectivity. Diffusion-weighted imaging was used to perform probabilistic tractography of the decussating and nondecussating DRTT in young healthy subjects from the Human Connectome Project (n = 91) scanned using multi-shell diffusion-weighted imaging (270 directions; TR/TE = 5500/89 ms; spatial resolution = 1.25 mm isotropic). To define thalamic anatomical landmarks, a segmentation procedure based on the Morel Atlas was employed, and DRTT targeting was quantified based on the proportion of streamlines arriving at each nucleus. In parallel, functional connectivity analysis was performed using resting-state functional MRI (TR/TE = 720/33 ms; spatial resolution = 2 mm isotropic). It was found that the decussating and nondecussating DRTTs have significantly different thalamic endpoints, with the former preferentially targeting relatively anterior and lateral thalamic nuclei, and the latter connected to more posterior and medial nuclei (p < 0.001). Functional and structural connectivity measures were found to be significantly correlated (r = 0.45, p = 0.031). These findings provide new insight into pathways through which unilateral cerebellum can exert bilateral influence on movement and raise questions about the functional implications of ipsilateral cerebellar efferents." @default.
• W2801597267 created "2018-05-17" @default.
• W2801597267 creator A5014896512 @default.
• W2801597267 creator A5018601611 @default.
• W2801597267 creator A5043425044 @default.
• W2801597267 creator A5047066771 @default.
• W2801597267 creator A5055091241 @default.
• W2801597267 creator A5064135529 @default.
• W2801597267 creator A5064699036 @default.
• W2801597267 creator A5067586498 @default.
• W2801597267 creator A5068652911 @default.
• W2801597267 creator A5078302795 @default.
• W2801597267 date "2018-08-01" @default.
• W2801597267 modified "2023-10-14" @default.
• W2801597267 title "Structural and functional connectivity of the nondecussating dentato-rubro-thalamic tract" @default.
• W2801597267 cites W1479876183 @default.
• W2801597267 cites W1935352187 @default.
• W2801597267 cites W1963781350 @default.
• W2801597267 cites W1972545529 @default.
• W2801597267 cites W1979804242 @default.
• W2801597267 cites W1983208069 @default.
• W2801597267 cites W1986800256 @default.
• W2801597267 cites W1989965515 @default.
• W2801597267 cites W1993053013 @default.
• W2801597267 cites W1993442330 @default.
• W2801597267 cites W2000133863 @default.
• W2801597267 cites W2001601016 @default.
• W2801597267 cites W2001642586 @default.
• W2801597267 cites W2005319430 @default.
• W2801597267 cites W2005917643 @default.
• W2801597267 cites W2013224282 @default.
• W2801597267 cites W2024729467 @default.
• W2801597267 cites W2025162361 @default.
• W2801597267 cites W2034432063 @default.
• W2801597267 cites W2035801035 @default.
• W2801597267 cites W2037407575 @default.
• W2801597267 cites W2039861760 @default.
• W2801597267 cites W2052644075 @default.
• W2801597267 cites W2056048403 @default.
• W2801597267 cites W2067214598 @default.
• W2801597267 cites W2071881327 @default.
• W2801597267 cites W2080477922 @default.
• W2801597267 cites W2082240739 @default.
• W2801597267 cites W2089940272 @default.
• W2801597267 cites W2090490622 @default.
• W2801597267 cites W2096672020 @default.
• W2801597267 cites W2142059961 @default.
• W2801597267 cites W2142568997 @default.
• W2801597267 cites W2151209890 @default.
• W2801597267 cites W2160034651 @default.
• W2801597267 cites W2400707621 @default.
• W2801597267 cites W2593946404 @default.
• W2801597267 cites W2789360752 @default.
• W2801597267 cites W4235770099 @default.
• W2801597267 doi "https://doi.org/10.1016/j.neuroimage.2018.04.074" @default.
• W2801597267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6002752" @default.
• W2801597267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29733955" @default.
• W2801597267 hasPublicationYear "2018" @default.
• W2801597267 type Work @default.
• W2801597267 sameAs 2801597267 @default.
• W2801597267 citedByCount "42" @default.
• W2801597267 countsByYear W28015972672019 @default.
• W2801597267 countsByYear W28015972672020 @default.
• W2801597267 countsByYear W28015972672021 @default.
• W2801597267 countsByYear W28015972672022 @default.
• W2801597267 countsByYear W28015972672023 @default.
• W2801597267 crossrefType "journal-article" @default.
• W2801597267 hasAuthorship W2801597267A5014896512 @default.
• W2801597267 hasAuthorship W2801597267A5018601611 @default.
• W2801597267 hasAuthorship W2801597267A5043425044 @default.
• W2801597267 hasAuthorship W2801597267A5047066771 @default.
• W2801597267 hasAuthorship W2801597267A5055091241 @default.
• W2801597267 hasAuthorship W2801597267A5064135529 @default.
• W2801597267 hasAuthorship W2801597267A5064699036 @default.
• W2801597267 hasAuthorship W2801597267A5067586498 @default.
• W2801597267 hasAuthorship W2801597267A5068652911 @default.
• W2801597267 hasAuthorship W2801597267A5078302795 @default.
• W2801597267 hasBestOaLocation W28015972672 @default.
• W2801597267 hasConcept C105702510 @default.
• W2801597267 hasConcept C126838900 @default.
• W2801597267 hasConcept C142724271 @default.
• W2801597267 hasConcept C143409427 @default.
• W2801597267 hasConcept C149550507 @default.
• W2801597267 hasConcept C15744967 @default.
• W2801597267 hasConcept C169760540 @default.
• W2801597267 hasConcept C2778542668 @default.
• W2801597267 hasConcept C2779134260 @default.
• W2801597267 hasConcept C2779246727 @default.
• W2801597267 hasConcept C2779652256 @default.
• W2801597267 hasConcept C2779734285 @default.
• W2801597267 hasConcept C2780112193 @default.
• W2801597267 hasConcept C3018011982 @default.
• W2801597267 hasConcept C45715564 @default.
• W2801597267 hasConcept C529278444 @default.
• W2801597267 hasConcept C552161191 @default.
• W2801597267 hasConcept C71924100 @default.
• W2801597267 hasConcept C84787856 @default.
• W2801597267 hasConcept C86803240 @default.

• next