FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801604094> ?p ?o ?g. }

• W2801604094 endingPage "1357" @default.
• W2801604094 startingPage "1351" @default.
• W2801604094 abstract "Porphyria cutanea tarda (PCT) is the most common human porphyria. It is caused by hepatic deficiency of uroporphyrinogen decarboxylase activity, which is acquired in the presence of multiple susceptibility factors. PCT presents clinically with cutaneous blistering photosensitivity and is readily treatable with either repeated phlebotomy or 4‐aminoquinoline antimalarials. To perform a systematic review and meta‐analysis to compare the effectiveness of these quite different treatment approaches, especially on relapse rates (RRs) after achieving remission. Published studies that included follow‐up for at least 1 year after treatment of PCT were included. The primary study outcome was PCT relapse. Pooled data are reported as the RRs per person‐year of follow‐up with 95% confidence intervals (CIs). Of 375 articles identified as pertaining to PCT treatment, 12 were eligible for analysis. Of these, five used high‐dose 4‐aminoquinoline regimens (two combined with phlebotomy and three without phlebotomy), five used low‐dose 4‐aminoquinoline regimens and three used phlebotomy. RRs during the year after treatment were similar for the high‐ and low‐dose 4‐aminoquinoline groups (35–36%) and lower in the phlebotomy group (20%). The pooled RRs with their 95% CIs were 8·6 (3·9–13·3) per 100 person‐years in the high‐dose 4‐aminoquinoline group, 17·1 (8·9–25·3) per 100 person‐years in the low‐dose 4‐aminoquinoline group and 5·1 (0·5–10·6) per 100 person‐years in the phlebotomy group. Subgroup and sensitivity analyses showed similar results. Clinical or biochemical RRs ranged from 5 to 17 per 100 person‐years after remission of PCT. Relapses were somewhat more frequent after remission with 4‐aminoquinoline regimens than after remission following phlebotomy. Prospective studies are needed to define better how often relapses occur with these treatments after documenting both clinical and biochemical remission of PCT." @default.
• W2801604094 created "2018-05-17" @default.
• W2801604094 creator A5046827767 @default.
• W2801604094 creator A5071669604 @default.
• W2801604094 creator A5080253395 @default.
• W2801604094 creator A5081057626 @default.
• W2801604094 creator A5087206886 @default.
• W2801604094 creator A5090178592 @default.
• W2801604094 date "2018-07-26" @default.
• W2801604094 modified "2023-09-27" @default.
• W2801604094 title "Relapse of porphyria cutanea tarda after treatment with phlebotomy or 4-aminoquinoline antimalarials: a meta-analysis" @default.
• W2801604094 cites W157524803 @default.
• W2801604094 cites W193217377 @default.
• W2801604094 cites W1964435302 @default.
• W2801604094 cites W1969299762 @default.
• W2801604094 cites W1971236695 @default.
• W2801604094 cites W1974662191 @default.
• W2801604094 cites W1976380896 @default.
• W2801604094 cites W1979423827 @default.
• W2801604094 cites W1987377490 @default.
• W2801604094 cites W1994999960 @default.
• W2801604094 cites W2005905882 @default.
• W2801604094 cites W2017044005 @default.
• W2801604094 cites W2021130100 @default.
• W2801604094 cites W2025937284 @default.
• W2801604094 cites W2027668872 @default.
• W2801604094 cites W2033585778 @default.
• W2801604094 cites W2042125845 @default.
• W2801604094 cites W2045488217 @default.
• W2801604094 cites W2054750608 @default.
• W2801604094 cites W2065842554 @default.
• W2801604094 cites W2083725441 @default.
• W2801604094 cites W2083733005 @default.
• W2801604094 cites W2085107169 @default.
• W2801604094 cites W2094319822 @default.
• W2801604094 cites W2103484846 @default.
• W2801604094 cites W2107328434 @default.
• W2801604094 cites W2112224442 @default.
• W2801604094 cites W2112318413 @default.
• W2801604094 cites W2117207930 @default.
• W2801604094 cites W2125435699 @default.
• W2801604094 cites W2126118465 @default.
• W2801604094 cites W2126709509 @default.
• W2801604094 cites W2146120379 @default.
• W2801604094 cites W2157823046 @default.
• W2801604094 cites W2176620936 @default.
• W2801604094 cites W2223558790 @default.
• W2801604094 cites W2259591797 @default.
• W2801604094 cites W2279664783 @default.
• W2801604094 cites W2398618895 @default.
• W2801604094 cites W2411173078 @default.
• W2801604094 cites W2411285524 @default.
• W2801604094 cites W2472696230 @default.
• W2801604094 cites W2473825014 @default.
• W2801604094 cites W2476723722 @default.
• W2801604094 cites W2588681363 @default.
• W2801604094 cites W4299610678 @default.
• W2801604094 cites W2467733963 @default.
• W2801604094 doi "https://doi.org/10.1111/bjd.16741" @default.
• W2801604094 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6230514" @default.
• W2801604094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29750336" @default.
• W2801604094 hasPublicationYear "2018" @default.
• W2801604094 type Work @default.
• W2801604094 sameAs 2801604094 @default.
• W2801604094 citedByCount "9" @default.
• W2801604094 countsByYear W28016040942018 @default.
• W2801604094 countsByYear W28016040942019 @default.
• W2801604094 countsByYear W28016040942020 @default.
• W2801604094 countsByYear W28016040942021 @default.
• W2801604094 countsByYear W28016040942022 @default.
• W2801604094 crossrefType "journal-article" @default.
• W2801604094 hasAuthorship W2801604094A5046827767 @default.
• W2801604094 hasAuthorship W2801604094A5071669604 @default.
• W2801604094 hasAuthorship W2801604094A5080253395 @default.
• W2801604094 hasAuthorship W2801604094A5081057626 @default.
• W2801604094 hasAuthorship W2801604094A5087206886 @default.
• W2801604094 hasAuthorship W2801604094A5090178592 @default.
• W2801604094 hasBestOaLocation W28016040942 @default.
• W2801604094 hasConcept C126322002 @default.
• W2801604094 hasConcept C172110603 @default.
• W2801604094 hasConcept C181199279 @default.
• W2801604094 hasConcept C185592680 @default.
• W2801604094 hasConcept C2776217839 @default.
• W2801604094 hasConcept C2777357209 @default.
• W2801604094 hasConcept C2777940757 @default.
• W2801604094 hasConcept C2781223928 @default.
• W2801604094 hasConcept C44249647 @default.
• W2801604094 hasConcept C55493867 @default.
• W2801604094 hasConcept C71924100 @default.
• W2801604094 hasConcept C90924648 @default.
• W2801604094 hasConcept C95190672 @default.
• W2801604094 hasConceptScore W2801604094C126322002 @default.
• W2801604094 hasConceptScore W2801604094C172110603 @default.
• W2801604094 hasConceptScore W2801604094C181199279 @default.
• W2801604094 hasConceptScore W2801604094C185592680 @default.
• W2801604094 hasConceptScore W2801604094C2776217839 @default.
• W2801604094 hasConceptScore W2801604094C2777357209 @default.
• W2801604094 hasConceptScore W2801604094C2777940757 @default.

• next