FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801618984> ?p ?o ?g. }

• W2801618984 endingPage "C257" @default.
• W2801618984 startingPage "C247" @default.
• W2801618984 abstract "Cerebral palsy (CP) is the most common cause of pediatric neurodevelopmental and physical disability in the United States. It is defined as a group of motor disorders caused by a nonprogressive perinatal insult to the brain. Although the brain lesion is nonprogressive, there is a progressive, lifelong impact on skeletal muscles, which are shorter, spastic, and may develop debilitating contractures. Satellite cells are resident muscle stem cells that are indispensable for postnatal growth and regeneration of skeletal muscles. Here we measured the myogenic potential of satellite cells isolated from contractured muscles in children with CP. When compared with typically developing (TD) children, satellite cell-derived myoblasts from CP differentiated more slowly (slope: 0.013 (SD 0.013) CP vs. 0.091 (SD 0.024) TD over 24 h, P < 0.001) and fused less (fusion index: 21.3 (SD 8.6) CP vs. 81.3 (SD 7.7) TD after 48 h, P < 0.001) after exposure to low-serum conditions that stimulated myotube formation. This impairment was associated with downregulation of several markers important for myoblast fusion and myotube formation, including DNA methylation-dependent inhibition of promyogenic integrin-β 1D (ITGB1D) protein expression levels (−50% at 42 h), and ~25% loss of integrin-mediated focal adhesion kinase phosphorylation. The cytidine analog 5-Azacytidine (5-AZA), a demethylating agent, restored ITGB1D levels and promoted myogenesis in CP cultures. Our data demonstrate that muscle contractures in CP are associated with loss of satellite cell myogenic potential that is dependent on DNA methylation patterns affecting expression of genetic programs associated with muscle stem cell differentiation and muscle fiber formation." @default.
• W2801618984 created "2018-05-17" @default.
• W2801618984 creator A5011976108 @default.
• W2801618984 creator A5018754809 @default.
• W2801618984 creator A5018901294 @default.
• W2801618984 creator A5044675432 @default.
• W2801618984 creator A5057911431 @default.
• W2801618984 creator A5058611356 @default.
• W2801618984 creator A5088879381 @default.
• W2801618984 date "2018-08-01" @default.
• W2801618984 modified "2023-10-17" @default.
• W2801618984 title "Loss of myogenic potential and fusion capacity of muscle stem cells isolated from contractured muscle in children with cerebral palsy" @default.
• W2801618984 cites W1482601876 @default.
• W2801618984 cites W1510986852 @default.
• W2801618984 cites W1532075073 @default.
• W2801618984 cites W1559509108 @default.
• W2801618984 cites W1569163094 @default.
• W2801618984 cites W1595606899 @default.
• W2801618984 cites W1802224131 @default.
• W2801618984 cites W1968270834 @default.
• W2801618984 cites W1970944947 @default.
• W2801618984 cites W1977233815 @default.
• W2801618984 cites W1992050281 @default.
• W2801618984 cites W1997546274 @default.
• W2801618984 cites W1998813619 @default.
• W2801618984 cites W2004028736 @default.
• W2801618984 cites W2006401112 @default.
• W2801618984 cites W2009100350 @default.
• W2801618984 cites W2017334368 @default.
• W2801618984 cites W2022487205 @default.
• W2801618984 cites W2023621146 @default.
• W2801618984 cites W2053987441 @default.
• W2801618984 cites W2059847471 @default.
• W2801618984 cites W2063045072 @default.
• W2801618984 cites W2063563320 @default.
• W2801618984 cites W2066851515 @default.
• W2801618984 cites W2069565002 @default.
• W2801618984 cites W2072182762 @default.
• W2801618984 cites W2091515620 @default.
• W2801618984 cites W2092395878 @default.
• W2801618984 cites W2093921801 @default.
• W2801618984 cites W2097304128 @default.
• W2801618984 cites W2097548633 @default.
• W2801618984 cites W2108509312 @default.
• W2801618984 cites W2110004046 @default.
• W2801618984 cites W2112326292 @default.
• W2801618984 cites W2112624928 @default.
• W2801618984 cites W2115424432 @default.
• W2801618984 cites W2117658071 @default.
• W2801618984 cites W2118581355 @default.
• W2801618984 cites W2121460378 @default.
• W2801618984 cites W2123564531 @default.
• W2801618984 cites W2126206176 @default.
• W2801618984 cites W2128147551 @default.
• W2801618984 cites W2128341617 @default.
• W2801618984 cites W2134183508 @default.
• W2801618984 cites W2136479767 @default.
• W2801618984 cites W2138313400 @default.
• W2801618984 cites W2145163771 @default.
• W2801618984 cites W2171773546 @default.
• W2801618984 cites W2224465478 @default.
• W2801618984 cites W2276231064 @default.
• W2801618984 cites W2287958167 @default.
• W2801618984 cites W2310664547 @default.
• W2801618984 cites W2345224831 @default.
• W2801618984 cites W2347839980 @default.
• W2801618984 cites W2411179491 @default.
• W2801618984 cites W2462524890 @default.
• W2801618984 cites W2464335124 @default.
• W2801618984 cites W2472586142 @default.
• W2801618984 cites W2504951283 @default.
• W2801618984 cites W2769209008 @default.
• W2801618984 cites W4211074903 @default.
• W2801618984 doi "https://doi.org/10.1152/ajpcell.00351.2017" @default.
• W2801618984 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6139501" @default.
• W2801618984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29694232" @default.
• W2801618984 hasPublicationYear "2018" @default.
• W2801618984 type Work @default.
• W2801618984 sameAs 2801618984 @default.
• W2801618984 citedByCount "30" @default.
• W2801618984 countsByYear W28016189842019 @default.
• W2801618984 countsByYear W28016189842020 @default.
• W2801618984 countsByYear W28016189842021 @default.
• W2801618984 countsByYear W28016189842022 @default.
• W2801618984 countsByYear W28016189842023 @default.
• W2801618984 crossrefType "journal-article" @default.
• W2801618984 hasAuthorship W2801618984A5011976108 @default.
• W2801618984 hasAuthorship W2801618984A5018754809 @default.
• W2801618984 hasAuthorship W2801618984A5018901294 @default.
• W2801618984 hasAuthorship W2801618984A5044675432 @default.
• W2801618984 hasAuthorship W2801618984A5057911431 @default.
• W2801618984 hasAuthorship W2801618984A5058611356 @default.
• W2801618984 hasAuthorship W2801618984A5088879381 @default.
• W2801618984 hasBestOaLocation W28016189841 @default.
• W2801618984 hasConcept C104317684 @default.
• W2801618984 hasConcept C126322002 @default.
• W2801618984 hasConcept C134018914 @default.
• W2801618984 hasConcept C150194340 @default.

• next