Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801639712> ?p ?o ?g. }
- W2801639712 endingPage "1386" @default.
- W2801639712 startingPage "1377" @default.
- W2801639712 abstract "A rapid and practical approach for the discovery of new chemical matter for targeting pathogens and diseases is described. Fragment-based phenotypic lead discovery (FPLD) combines aspects of traditional fragment-based lead discovery (FBLD), which involves the screening of small-molecule fragment libraries to target specific proteins, with phenotypic lead discovery (PLD), which typically involves the screening of drug-like compounds in cell-based assays. To enable FPLD, a diverse library of fragments was first designed, assembled, and curated. This library of soluble, low-molecular-weight compounds was then pooled to expedite screening. Axenic cultures of Leishmania promastigotes were screened, and single hits were then tested for leishmanicidal activity against intracellular amastigote forms in infected murine bone-marrow-derived macrophages without evidence of toxicity toward mammalian cells. These studies demonstrate that FPLD can be a rapid and effective means to discover hits that can serve as leads for further medicinal chemistry purposes or as tool compounds for identifying known or novel targets." @default.
- W2801639712 created "2018-05-17" @default.
- W2801639712 creator A5026276673 @default.
- W2801639712 creator A5038183087 @default.
- W2801639712 creator A5079221781 @default.
- W2801639712 creator A5085594761 @default.
- W2801639712 date "2018-05-30" @default.
- W2801639712 modified "2023-09-26" @default.
- W2801639712 title "Fragment-Based Phenotypic Lead Discovery: Cell-Based Assay to Target Leishmaniasis" @default.
- W2801639712 cites W131055120 @default.
- W2801639712 cites W1490283661 @default.
- W2801639712 cites W1569560012 @default.
- W2801639712 cites W1584602588 @default.
- W2801639712 cites W17045578 @default.
- W2801639712 cites W1771852563 @default.
- W2801639712 cites W1972821149 @default.
- W2801639712 cites W1977340881 @default.
- W2801639712 cites W1977879264 @default.
- W2801639712 cites W1981066521 @default.
- W2801639712 cites W1981596913 @default.
- W2801639712 cites W1986362532 @default.
- W2801639712 cites W1988452823 @default.
- W2801639712 cites W1995522821 @default.
- W2801639712 cites W2010814335 @default.
- W2801639712 cites W2019745946 @default.
- W2801639712 cites W2026269205 @default.
- W2801639712 cites W2026535663 @default.
- W2801639712 cites W2028816469 @default.
- W2801639712 cites W2029960874 @default.
- W2801639712 cites W2034644996 @default.
- W2801639712 cites W2037284663 @default.
- W2801639712 cites W2043509228 @default.
- W2801639712 cites W2044264690 @default.
- W2801639712 cites W2044609406 @default.
- W2801639712 cites W2046258407 @default.
- W2801639712 cites W2059088390 @default.
- W2801639712 cites W2062325702 @default.
- W2801639712 cites W2068905743 @default.
- W2801639712 cites W2069126953 @default.
- W2801639712 cites W2069563261 @default.
- W2801639712 cites W2073661736 @default.
- W2801639712 cites W2075146969 @default.
- W2801639712 cites W2076283593 @default.
- W2801639712 cites W2076755375 @default.
- W2801639712 cites W2084837014 @default.
- W2801639712 cites W2086208209 @default.
- W2801639712 cites W2087625398 @default.
- W2801639712 cites W2096330288 @default.
- W2801639712 cites W2100262434 @default.
- W2801639712 cites W2107685720 @default.
- W2801639712 cites W2115909994 @default.
- W2801639712 cites W2123191684 @default.
- W2801639712 cites W2137383619 @default.
- W2801639712 cites W2140171704 @default.
- W2801639712 cites W2142047724 @default.
- W2801639712 cites W2142161087 @default.
- W2801639712 cites W2154511186 @default.
- W2801639712 cites W2163023478 @default.
- W2801639712 cites W2198907191 @default.
- W2801639712 cites W2205755822 @default.
- W2801639712 cites W2217411574 @default.
- W2801639712 cites W2262786583 @default.
- W2801639712 cites W2314041260 @default.
- W2801639712 cites W2467779447 @default.
- W2801639712 cites W2478575915 @default.
- W2801639712 cites W2529431057 @default.
- W2801639712 cites W2570915324 @default.
- W2801639712 cites W2575838842 @default.
- W2801639712 cites W2604410491 @default.
- W2801639712 cites W2729684734 @default.
- W2801639712 cites W4239524565 @default.
- W2801639712 doi "https://doi.org/10.1002/cmdc.201800161" @default.
- W2801639712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29722149" @default.
- W2801639712 hasPublicationYear "2018" @default.
- W2801639712 type Work @default.
- W2801639712 sameAs 2801639712 @default.
- W2801639712 citedByCount "8" @default.
- W2801639712 countsByYear W28016397122018 @default.
- W2801639712 countsByYear W28016397122019 @default.
- W2801639712 countsByYear W28016397122020 @default.
- W2801639712 countsByYear W28016397122021 @default.
- W2801639712 countsByYear W28016397122023 @default.
- W2801639712 crossrefType "journal-article" @default.
- W2801639712 hasAuthorship W2801639712A5026276673 @default.
- W2801639712 hasAuthorship W2801639712A5038183087 @default.
- W2801639712 hasAuthorship W2801639712A5079221781 @default.
- W2801639712 hasAuthorship W2801639712A5085594761 @default.
- W2801639712 hasConcept C104317684 @default.
- W2801639712 hasConcept C127716648 @default.
- W2801639712 hasConcept C136764020 @default.
- W2801639712 hasConcept C161624437 @default.
- W2801639712 hasConcept C199360897 @default.
- W2801639712 hasConcept C202751555 @default.
- W2801639712 hasConcept C2776235265 @default.
- W2801639712 hasConcept C2777752112 @default.
- W2801639712 hasConcept C2778265057 @default.
- W2801639712 hasConcept C2779057010 @default.
- W2801639712 hasConcept C2781092759 @default.