Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801647683> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2801647683 endingPage "S214" @default.
- W2801647683 startingPage "S214" @default.
- W2801647683 abstract "G-protein-coupled receptors (GPCRs) comprise a large family of cell-surface receptors that transduce signals through interaction with heterotrimeric G-protein subunits (Gα, Gβ, and Gy). The aberrant expression, overexpression or signal reprogramming of GPCRs and G-proteins have been linked to cancer initiation, tumor cell growth, metastasis and angiogenesis. Frequent somatic mutations of Gnaq and Gna11 were found in uveal melanomas of humans thereby identifying these G-proteins as potential oncogenes in human neoplasia. As a future perspective the inhibition of wild-type and/or mutated Gq-GPCRs may represent an effective molecular intervention to target oncogenic signaling. Currently there are only two known selective Gq/11-inhibitors, FR-900359 and YM-254890, which are of potential interest to target oncogenic signaling. Here we analyzed the role of GPCR-Gαq signaling in primary and transplantable Hgf-Cdk4R24C mouse melanomas using FR-900359 in vitro and in vivo. We also examined the effect of FR-900359 and YM-254890 on human uveal melanoma cells carrying wild-type or mutated Gnaq genes. We found that oncogenic mutations in Gnaq/11 appear to be selected in primary Hgf-Cdk4 mouse melanomas. All transplantable Hgf-Cdk4 mouse melanomas including HCmel12 and HCmel3 carried oncogenic mutations in Gnaq/11 genes. FR-900359 inhibited the proliferation of the GnaqQ209L–mutated HCmel12 mouse melanoma cell line and abrogated ERK activation. FR-900359 and YM-254890 both reduced the proliferation and ERK activation of Gnaq–mutated uveal melanoma cells but had no effect on Gnaq wild-type uveal melanoma cells. Future studies will have to address how exactly Gaq-coupled receptors transduce proliferative signals in melanoma cells and how these pathways contribute to growth and migration of tumor cells." @default.
- W2801647683 created "2018-05-17" @default.
- W2801647683 creator A5006742550 @default.
- W2801647683 creator A5022966339 @default.
- W2801647683 creator A5037908822 @default.
- W2801647683 creator A5048243966 @default.
- W2801647683 creator A5090032714 @default.
- W2801647683 date "2018-05-01" @default.
- W2801647683 modified "2023-09-27" @default.
- W2801647683 title "1259 Effect of selective Gq/11-inhibition on malignant melanoma" @default.
- W2801647683 doi "https://doi.org/10.1016/j.jid.2018.03.1274" @default.
- W2801647683 hasPublicationYear "2018" @default.
- W2801647683 type Work @default.
- W2801647683 sameAs 2801647683 @default.
- W2801647683 citedByCount "0" @default.
- W2801647683 crossrefType "journal-article" @default.
- W2801647683 hasAuthorship W2801647683A5006742550 @default.
- W2801647683 hasAuthorship W2801647683A5022966339 @default.
- W2801647683 hasAuthorship W2801647683A5037908822 @default.
- W2801647683 hasAuthorship W2801647683A5048243966 @default.
- W2801647683 hasAuthorship W2801647683A5090032714 @default.
- W2801647683 hasBestOaLocation W28016476831 @default.
- W2801647683 hasConcept C104317684 @default.
- W2801647683 hasConcept C135285700 @default.
- W2801647683 hasConcept C139407321 @default.
- W2801647683 hasConcept C21790070 @default.
- W2801647683 hasConcept C2777658100 @default.
- W2801647683 hasConcept C2779176653 @default.
- W2801647683 hasConcept C2781187634 @default.
- W2801647683 hasConcept C501734568 @default.
- W2801647683 hasConcept C502942594 @default.
- W2801647683 hasConcept C54355233 @default.
- W2801647683 hasConcept C57074206 @default.
- W2801647683 hasConcept C62112901 @default.
- W2801647683 hasConcept C62478195 @default.
- W2801647683 hasConcept C80631254 @default.
- W2801647683 hasConcept C86803240 @default.
- W2801647683 hasConcept C95444343 @default.
- W2801647683 hasConceptScore W2801647683C104317684 @default.
- W2801647683 hasConceptScore W2801647683C135285700 @default.
- W2801647683 hasConceptScore W2801647683C139407321 @default.
- W2801647683 hasConceptScore W2801647683C21790070 @default.
- W2801647683 hasConceptScore W2801647683C2777658100 @default.
- W2801647683 hasConceptScore W2801647683C2779176653 @default.
- W2801647683 hasConceptScore W2801647683C2781187634 @default.
- W2801647683 hasConceptScore W2801647683C501734568 @default.
- W2801647683 hasConceptScore W2801647683C502942594 @default.
- W2801647683 hasConceptScore W2801647683C54355233 @default.
- W2801647683 hasConceptScore W2801647683C57074206 @default.
- W2801647683 hasConceptScore W2801647683C62112901 @default.
- W2801647683 hasConceptScore W2801647683C62478195 @default.
- W2801647683 hasConceptScore W2801647683C80631254 @default.
- W2801647683 hasConceptScore W2801647683C86803240 @default.
- W2801647683 hasConceptScore W2801647683C95444343 @default.
- W2801647683 hasIssue "5" @default.
- W2801647683 hasLocation W28016476831 @default.
- W2801647683 hasOpenAccess W2801647683 @default.
- W2801647683 hasPrimaryLocation W28016476831 @default.
- W2801647683 hasRelatedWork W2039415986 @default.
- W2801647683 hasRelatedWork W2041467949 @default.
- W2801647683 hasRelatedWork W2118511673 @default.
- W2801647683 hasRelatedWork W2141202463 @default.
- W2801647683 hasRelatedWork W2164992866 @default.
- W2801647683 hasRelatedWork W2885767093 @default.
- W2801647683 hasRelatedWork W3126366955 @default.
- W2801647683 hasRelatedWork W3129743340 @default.
- W2801647683 hasRelatedWork W4362493042 @default.
- W2801647683 hasRelatedWork W4362495258 @default.
- W2801647683 hasVolume "138" @default.
- W2801647683 isParatext "false" @default.
- W2801647683 isRetracted "false" @default.
- W2801647683 magId "2801647683" @default.
- W2801647683 workType "article" @default.